|
|
char = R;code = 82
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char = f;code = 102
char = ;code = 32
char = f;code = 102
char = a;code = 97
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char = l;code = 108
char = c;code = 99
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char = u;code = 117
char = m;code = 109
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char = c;code = 99
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char = a;code = 97
char = u;code = 117
char = s;code = 115
char = a;code = 97
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char = b;code = 98
char = y;code = 121
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char = a;code = 97
char = m;code = 109
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char = n;code = 110
char = e;code = 101
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result sql = Role of fat and calcium in cancer causation by food mutagens, heterocyclic amines.
Role of fat and calcium in cancer causation by food mutagens, heterocyclic amines.char = W;code = 87
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char = ;code = 32
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char = n;code = 110
char = v;code = 118
char = e;code = 101
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = b;code = 98
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char = ;code = 32
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char = e;code = 101
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char = c;code = 99
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char = r;code = 114
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = i;code = 105
char = l;code = 108
char = ;code = 32
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char = d;code = 100
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
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char = r;code = 114
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char = i;code = 105
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char = H;code = 72
char = C;code = 67
char = A;code = 65
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char = ,;code = 44
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char = ;code = 32
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char = l;code = 108
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
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char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
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char = n;code = 110
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char = t;code = 116
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = a;code = 97
char = l;code = 108
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char = m;code = 109
char = e;code = 101
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char = ,;code = 44
char = ;code = 32
char = s;code = 115
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char = n;code = 110
char = c;code = 99
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
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char = f;code = 102
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char = d;code = 100
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char = ;code = 32
char = c;code = 99
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char = o;code = 111
char = k;code = 107
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = w;code = 119
char = o;code = 111
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char = a;code = 97
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char = p;code = 112
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char = e;code = 101
char = s;code = 115
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char = (;code = 40
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
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char = s;code = 115
char = a;code = 97
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = F;code = 70
char = 3;code = 51
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char = 4;code = 52
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char = d;code = 100
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char = i;code = 105
char = i;code = 105
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = b;code = 98
char = b;code = 98
char = r;code = 114
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char = v;code = 118
char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = ,;code = 44
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = i;code = 105
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char = u;code = 117
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = f;code = 102
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char = c;code = 99
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char = o;code = 111
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char = a;code = 97
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char = c;code = 99
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char = y;code = 121
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char = i;code = 105
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char = c;code = 99
char = o;code = 111
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char = o;code = 111
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char = i;code = 105
char = n;code = 110
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char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = F;code = 70
char = 3;code = 51
char = 4;code = 52
char = 4;code = 52
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = O;code = 79
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = H;code = 72
char = C;code = 67
char = A;code = 65
char = ,;code = 44
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char = 2;code = 50
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char = a;code = 97
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char = m;code = 109
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result sql = We investigated the modulation by dietary corn oil and calcium levels of carcinogenesis by heterocyclic amines (HCA), a new class of important carcinogens in the human nutritional environment, since they are formed during cooking. Two approaches involved (i) a chronic bioassay in male and female F344 rats, and (ii) an abbreviated test, the induction of foci of aberrant crypts in the colon in male F344 rats. One typical HCA, 2-amino-3-methylimidazo [4,5-f]quinoline (IQ) was fed at 75 ppm for 12 months to male and female rats that were held three and six months longer, respectively, on control diets. Neoplasms were induced in the Zymbal gland, skin (predominantly in male rats), liver, mammary and preputial glands, colon, and lung. Diets with 23.5% corn oil increased carcinomas in the liver in males, and in the mammary gland in females, compared with a 5% corn oil diet. Males on the low-fat diet had more cancers in the lip, and females had more ear duct cancers, than did rats on the high-fat diet. Another HCA, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), fed at 400 ppm for nine weeks induced foci of aberrant crypts in the lower intestinal tract of male F344 rats. There were significantly more aberrant crypts on the high-fat than on the low-fat diet. On the low-fat diet, there were fewer aberrant crypts on the higher calcium level. Thus, dietary fat modulates the carcinogenic action of HCA food carcinogens in specific organs of male and female F344 rats. Also, both fat and calcium affected the induction of aberrant crypts in the distal intestinal tract of male F344 rats.
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result sql = Role of fat and calcium in cancer causation by food mutagens, heterocyclic amines.
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char = o;code = 111
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char = r;code = 114
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char = o;code = 111
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char = d;code = 100
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = u;code = 117
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char = l;code = 108
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char = v;code = 118
char = e;code = 101
char = l;code = 108
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char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
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char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = b;code = 98
char = y;code = 121
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char = h;code = 104
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = c;code = 99
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char = c;code = 99
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
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char = H;code = 72
char = C;code = 67
char = A;code = 65
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = w;code = 119
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char = c;code = 99
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = t;code = 116
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char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
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char = n;code = 110
char = o;code = 111
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char = e;code = 101
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
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char = h;code = 104
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char = a;code = 97
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char = n;code = 110
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char = t;code = 116
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = a;code = 97
char = l;code = 108
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char = e;code = 101
char = n;code = 110
char = v;code = 118
char = i;code = 105
char = r;code = 114
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char = n;code = 110
char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = ;code = 32
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = t;code = 116
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char = e;code = 101
char = y;code = 121
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char = a;code = 97
char = r;code = 114
char = e;code = 101
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = w;code = 119
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = a;code = 97
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = v;code = 118
char = o;code = 111
char = l;code = 108
char = v;code = 118
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char = d;code = 100
char = ;code = 32
char = (;code = 40
char = i;code = 105
char = );code = 41
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = c;code = 99
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char = b;code = 98
char = i;code = 105
char = o;code = 111
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = a;code = 97
char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = F;code = 70
char = 3;code = 51
char = 4;code = 52
char = 4;code = 52
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char = r;code = 114
char = a;code = 97
char = t;code = 116
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
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char = i;code = 105
char = i;code = 105
char = );code = 41
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char = a;code = 97
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char = a;code = 97
char = b;code = 98
char = b;code = 98
char = r;code = 114
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char = v;code = 118
char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = t;code = 116
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char = e;code = 101
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char = i;code = 105
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char = d;code = 100
char = u;code = 117
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char = o;code = 111
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char = f;code = 102
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char = f;code = 102
char = o;code = 111
char = c;code = 99
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char = ;code = 32
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char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = t;code = 116
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char = c;code = 99
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char = y;code = 121
char = p;code = 112
char = t;code = 116
char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = l;code = 108
char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = F;code = 70
char = 3;code = 51
char = 4;code = 52
char = 4;code = 52
char = ;code = 32
char = r;code = 114
char = a;code = 97
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char = s;code = 115
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char = ;code = 32
char = O;code = 79
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char = e;code = 101
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char = t;code = 116
char = y;code = 121
char = p;code = 112
char = i;code = 105
char = c;code = 99
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char = H;code = 72
char = C;code = 67
char = A;code = 65
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char = 2;code = 50
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char = 5;code = 53
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char = ;code = 32
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
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char = p;code = 112
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char = e;code = 101
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char = a;code = 97
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char = s;code = 115
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char = e;code = 101
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char = x;code = 120
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char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = v;code = 118
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char = y;code = 121
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char = c;code = 99
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char = o;code = 111
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char = i;code = 105
char = e;code = 101
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = e;code = 101
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char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = m;code = 109
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = i;code = 105
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char = d;code = 100
char = u;code = 117
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = Z;code = 90
char = y;code = 121
char = m;code = 109
char = b;code = 98
char = a;code = 97
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char = g;code = 103
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char = a;code = 97
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char = d;code = 100
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char = s;code = 115
char = k;code = 107
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = f;code = 102
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char = 5;code = 53
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char = e;code = 101
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char = p;code = 112
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char = a;code = 97
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result sql = We investigated the modulation by dietary corn oil and calcium levels of carcinogenesis by heterocyclic amines (HCA), a new class of important carcinogens in the human nutritional environment, since they are formed during cooking. Two approaches involved (i) a chronic bioassay in male and female F344 rats, and (ii) an abbreviated test, the induction of foci of aberrant crypts in the colon in male F344 rats. One typical HCA, 2-amino-3-methylimidazo [4,5-f]quinoline (IQ) was fed at 75 ppm for 12 months to male and female rats that were held three and six months longer, respectively, on control diets. Neoplasms were induced in the Zymbal gland, skin (predominantly in male rats), liver, mammary and preputial glands, colon, and lung. Diets with 23.5% corn oil increased carcinomas in the liver in males, and in the mammary gland in females, compared with a 5% corn oil diet. Males on the low-fat diet had more cancers in the lip, and females had more ear duct cancers, than did rats on the high-fat diet. Another HCA, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), fed at 400 ppm for nine weeks induced foci of aberrant crypts in the lower intestinal tract of male F344 rats. There were significantly more aberrant crypts on the high-fat than on the low-fat diet. On the low-fat diet, there were fewer aberrant crypts on the higher calcium level. Thus, dietary fat modulates the carcinogenic action of HCA food carcinogens in specific organs of male and female F344 rats. Also, both fat and calcium affected the induction of aberrant crypts in the distal intestinal tract of male F344 rats.
Publication: Proc. Soc. Exp. Biol. Med. 1994 Apr ;205(4)::347-52.
Publication Date: 1994 Apr
Study Author(s): Weisburger, J H;Rivenson, A;Hard, G C;Zang, E;Nagao, M;Sugimura, T;
Institution: American Health Foundation, Valhalla, New York 10595.
Shortcut link to this study:
Publication Date: 1994 Apr
Study Author(s): Weisburger, J H;Rivenson, A;Hard, G C;Zang, E;Nagao, M;Sugimura, T;
Institution: American Health Foundation, Valhalla, New York 10595.
Shortcut link to this study:
We investigated the modulation by dietary corn oil and calcium levels of carcinogenesis by heterocyclic amines (HCA), a new class of important carcinogens in the human nutritional environment, since they are formed during cooking. Two approaches involved (i) a chronic bioassay in male and female F344 rats, and (ii) an abbreviated test, the induction of foci of aberrant crypts in the colon in male F344 rats. One typical HCA, 2-amino-3-methylimidazo [4,5-f]quinoline (IQ) was fed at 75 ppm for 12 months to male and female rats that were held three and six months longer, respectively, on control diets. Neoplasms were induced in the Zymbal gland, skin (predominantly in male rats), liver, mammary and preputial glands, colon, and lung. Diets with 23.5% corn oil increased carcinomas in the liver in males, and in the mammary gland in females, compared with a 5% corn oil diet. Males on the low-fat diet had more cancers in the lip, and females had more ear duct cancers, than did rats on the high-fat diet. Another HCA, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), fed at 400 ppm for nine weeks induced foci of aberrant crypts in the lower intestinal tract of male F344 rats. There were significantly more aberrant crypts on the high-fat than on the low-fat diet. On the low-fat diet, there were fewer aberrant crypts on the higher calcium level. Thus, dietary fat modulates the carcinogenic action of HCA food carcinogens in specific organs of male and female F344 rats. Also, both fat and calcium affected the induction of aberrant crypts in the distal intestinal tract of male F344 rats.
PMID: 8171059
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