char = T;code = 84
char = h;code = 104
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char = e;code = 101
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char = m;code = 109
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char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = .;code = 46
result sql = The oxytocin receptor, luteolysis and the maintenance of pregnancy.
The oxytocin receptor, luteolysis and the maintenance of pregnancy.
char = D;code = 68
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char = i;code = 105
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char = l;code = 108
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char = g;code = 103
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = s;code = 115
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char = s;code = 115
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char = ;code = 32
char = o;code = 111
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char = b;code = 98
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char = F;code = 70
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char = a;code = 97
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char = l;code = 108
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char = s;code = 115
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char = n;code = 110
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = o;code = 111
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char = ;code = 32
char = e;code = 101
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char = d;code = 100
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char = a;code = 97
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char = g;code = 103
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char = a;code = 97
char = n;code = 110
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char = b;code = 98
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char = t;code = 116
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char = ;code = 32
char = t;code = 116
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char = d;code = 100
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char = e;code = 101
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char = o;code = 111
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = p;code = 112
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char = l;code = 108
char = s;code = 115
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char = i;code = 105
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char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = P;code = 80
char = G;code = 71
char = F;code = 70
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = a;code = 97
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char = e;code = 101
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char = e;code = 101
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char = i;code = 105
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char = e;code = 101
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = O;code = 79
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char = y;code = 121
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char = c;code = 99
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char = e;code = 101
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char = ;code = 32
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char = e;code = 101
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char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = n;code = 110
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char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
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char = e;code = 101
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char = e;code = 101
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char = i;code = 105
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char = m;code = 109
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char = o;code = 111
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char = a;code = 97
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char = e;code = 101
char = c;code = 99
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char = z;code = 122
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char = t;code = 116
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char = T;code = 84
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char = I;code = 73
char = F;code = 70
char = N;code = 78
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char = t;code = 116
char = a;code = 97
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result sql = During luteal regression episodic pulses of oxytocin secretion become coupled to the release of prostaglandin F2 alpha (PGF2 alpha) following synthesis of endometrial oxytocin receptors, but in early pregnancy the inhibition of oxytocin receptor formation by the conceptus prevents the development of the pulsatile pattern of PGF2 alpha release needed to achieve luteolysis. Oxytocin receptors are present on the luminal epithelium in ovariectomized and anoestrous ewes, in pregnant animals throughout most of gestation (day 21 to term) and in explants of endometrial tissue cultured in vitro. These receptors can be downregulated for a brief period by progesterone (10-12 days in sheep, 12-14 days in cattle). This period of inhibition can be extended by infusion of interferon tau (IFN-tau) (which probably inhibits oxytocin receptor gene transcription) or of oxytocin into the systemic circulation (which may act further downstream, possibly at the level of translation). Oxytocin receptors also develop on the caruncular stroma and deep glands at oestrus, but these need positive upregulation and appear dependent on an oestrogenic environment. Only epithelial receptors are needed to achieve a maximal PGF2 alpha response to an oxytocin challenge, but the presence of oxytocin receptors does not necessarily confer responsiveness as other factors may influence intracellular coupling mechanisms and precursor availability. The duration of the luteal phase is regulated by the time of the initial post-ovulatory rise in progesterone and the duration of exposure to progesterone.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication: J. Reprod. Fertil. Suppl. 1995 ;49:53-67.
Publication Date: 1995
Study Author(s): Wathes, D C;Lamming, G E;
Institution: Department of Animal Health, Royal Veterinary College, Boltons Park, Herts, UK.
Shortcut link to this study:
During luteal regression episodic pulses of oxytocin secretion become coupled to the release of prostaglandin F2 alpha (PGF2 alpha) following synthesis of endometrial oxytocin receptors, but in early pregnancy the inhibition of oxytocin receptor formation by the conceptus prevents the development of the pulsatile pattern of PGF2 alpha release needed to achieve luteolysis. Oxytocin receptors are present on the luminal epithelium in ovariectomized and anoestrous ewes, in pregnant animals throughout most of gestation (day 21 to term) and in explants of endometrial tissue cultured in vitro. These receptors can be downregulated for a brief period by progesterone (10-12 days in sheep, 12-14 days in cattle). This period of inhibition can be extended by infusion of interferon tau (IFN-tau) (which probably inhibits oxytocin receptor gene transcription) or of oxytocin into the systemic circulation (which may act further downstream, possibly at the level of translation). Oxytocin receptors also develop on the caruncular stroma and deep glands at oestrus, but these need positive upregulation and appear dependent on an oestrogenic environment. Only epithelial receptors are needed to achieve a maximal PGF2 alpha response to an oxytocin challenge, but the presence of oxytocin receptors does not necessarily confer responsiveness as other factors may influence intracellular coupling mechanisms and precursor availability. The duration of the luteal phase is regulated by the time of the initial post-ovulatory rise in progesterone and the duration of exposure to progesterone.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID: 7623343

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