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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = A;code = 65
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char = ;code = 32
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char = n;code = 110
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char = m;code = 109
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char = l;code = 108
char = l;code = 108
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char = c;code = 99
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char = l;code = 108
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char = l;code = 108
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char = l;code = 108
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char = l;code = 108
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char = ;code = 32
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char = L;code = 76
char = 1;code = 49
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char = 3;code = 51
char = .;code = 46
result sql = Calcium ionophore A23187 inhibits ACTH secretion from a human small cell lung cancer cell line, COR-L103.
Calcium ionophore A23187 inhibits ACTH secretion from a human small cell lung cancer cell line, COR-L103.
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = f;code = 102
char = ;code = 32
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char = r;code = 114
char = m;code = 109
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char = e;code = 101
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char = (;code = 40
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char = R;code = 82
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char = );code = 41
char = ,;code = 44
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char = d;code = 100
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char = h;code = 104
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char = o;code = 111
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char = m;code = 109
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char = i;code = 105
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char = e;code = 101
char = ;code = 32
char = A;code = 65
char = 2;code = 50
char = 3;code = 51
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char = ;code = 32
char = 1;code = 49
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char = T;code = 84
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char = A;code = 65
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char = d;code = 100
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char = 8;code = 56
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char = m;code = 109
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char = o;code = 111
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char = o;code = 111
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char = i;code = 105
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char = r;code = 114
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char = i;code = 105
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char = ;code = 32
char = (;code = 40
char = P;code = 80
char = O;code = 79
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char = C;code = 67
char = );code = 41
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char = i;code = 105
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char = e;code = 101
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = R;code = 82
char = -;code = 45
char = L;code = 76
char = 1;code = 49
char = 0;code = 48
char = 3;code = 51
char = .;code = 46
char = ;code = 32
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char = o;code = 111
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char = e;code = 101
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char = c;code = 99
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result sql = The mechanism of ectopic adrenocorticotrophic hormone (ACTH) secretion was examined by studies on the effects of corticotropin-releasing hormone (CRH), dexamethasone, interleukin (IL)-1 beta and 2, somatostatin, calcium ionophore A23187, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 8-bromo-cAMP on pro-opiomelanocortin (POMC) expression and ACTH secretion from a human small cell lung cancer cell line COR-L103. None of these agents except TPA and A23187 had any effect on ACTH secretion from the cell line in short (0-8 hrs) or long term (1-4 days) cultures. In long term cultures, 1-100 nM TPA stimulated ACTH secretion dose-dependently, whereas 500nM A23187 inhibited ACTH secretion completely. When the cells were incubated with 10nM TPA plus 500 nM A23187, the inhibitory action of A23187 on ACTH secretion was suppressed by TPA. These results suggest that the mechanisms of ACTH secretion by COR-L103 cells and normal pituitary cells are different.

Publication: Biochem. Biophys. Res. Commun. 1995 Feb 6 ;207(1)::238-43.
Publication Date: 1995 Feb 6
Study Author(s): Zhang, C Y;Fujinaka, Y;Yokogoshi, Y;Saito, S;
Institution: First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Shortcut link to this study:
The mechanism of ectopic adrenocorticotrophic hormone (ACTH) secretion was examined by studies on the effects of corticotropin-releasing hormone (CRH), dexamethasone, interleukin (IL)-1 beta and 2, somatostatin, calcium ionophore A23187, 12-O-tetradecanoylphorbol-13-acetate (TPA) and 8-bromo-cAMP on pro-opiomelanocortin (POMC) expression and ACTH secretion from a human small cell lung cancer cell line COR-L103. None of these agents except TPA and A23187 had any effect on ACTH secretion from the cell line in short (0-8 hrs) or long term (1-4 days) cultures. In long term cultures, 1-100 nM TPA stimulated ACTH secretion dose-dependently, whereas 500nM A23187 inhibited ACTH secretion completely. When the cells were incubated with 10nM TPA plus 500 nM A23187, the inhibitory action of A23187 on ACTH secretion was suppressed by TPA. These results suggest that the mechanisms of ACTH secretion by COR-L103 cells and normal pituitary cells are different.
PMID: 7857271

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