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result sql = NG-nitro-L-arginine sensitizes mice to 4-aminopyridine-induced seizures.

NG-nitro-L-arginine sensitizes mice to 4-aminopyridine-induced seizures.

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char = (;code = 40
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char = ;code = 32
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char = e;code = 101
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char = +;code = 43
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = e;code = 101
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char = ;code = 32
char = a;code = 97
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char = t;code = 116
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char = g;code = 103
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = ,;code = 44
char = ;code = 32
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char = n;code = 110
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
char = ;code = 32
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char = N;code = 78
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char = ;code = 32
char = (;code = 40
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char = ;code = 32
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char = ;code = 32
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char = );code = 41
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = n;code = 110
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char = l;code = 108
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char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
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char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = ;code = 32
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char = ;code = 32
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char = ,;code = 44
char = ;code = 32
char = 7;code = 55
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char = ;code = 32
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char = f;code = 102
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char = ;code = 32
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char = 7;code = 55
char = .;code = 46
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char = ;code = 32
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char = .;code = 46
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char = ;code = 32
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char = ;code = 32
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char = ;code = 32
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char = a;code = 97
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char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = ,;code = 44
char = ;code = 32
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char = e;code = 101
char = p;code = 112
char = e;code = 101
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char = d;code = 100
char = e;code = 101
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char = ;code = 32
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char = n;code = 110
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result sql = We investigated the influence of NG-nitro-L-arginine (NNA), the inhibitor of nitric oxide synthese, on seizures induced by 4-aminopyridine (4-AP), the K+ channel antagonist, in mice NNA (5, 10 and 40 mg/kg, i.p.) significantly reduced the respectives CD50 of 4-AP from 9.0 to 7.6, 7.5 and 6.8 for clonic seizures, and from 9.2 to 7.7, 7.5 and 6.9 for tonic seizures and death. Lower doses of NNA (1.0 and 2.5 mg/kg) had no effect on 4-AP-induced convulsions and lethality. Our results indicate that 4-AP-induced seizures may be, at least in part, dependent on nitric oxide level.

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