char = C;code = 67
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = N;code = 78
char = I;code = 73
char = H;code = 72
char = ;code = 32
char = 3;code = 51
char = T;code = 84
char = 3;code = 51
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.
Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines.
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char = r;code = 114
char = c;code = 99
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char = m;code = 109
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = w;code = 119
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char = d;code = 100
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = u;code = 117
char = s;code = 115
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char = d;code = 100
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
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char = g;code = 103
char = m;code = 109
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char = d;code = 100
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char = b;code = 98
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char = d;code = 100
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char = m;code = 109
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = v;code = 118
char = e;code = 101
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char = i;code = 105
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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = u;code = 117
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char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = t;code = 116
char = i;code = 105
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = o;code = 111
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
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char = W;code = 87
char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = p;code = 112
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char = r;code = 114
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
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char = c;code = 99
char = u;code = 117
char = m;code = 109
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char = i;code = 105
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char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = k;code = 107
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = e;code = 101
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char = s;code = 115
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = D;code = 68
char = N;code = 78
char = A;code = 65
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char = f;code = 102
char = r;code = 114
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char = g;code = 103
char = m;code = 109
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char = i;code = 105
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char = ,;code = 44
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char = a;code = 97
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char = r;code = 114
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char = s;code = 115
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char = i;code = 105
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = s;code = 115
char = ,;code = 44
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char = ;code = 32
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char = m;code = 109
char = o;code = 111
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char = z;code = 122
char = e;code = 101
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char = ;code = 32
char = e;code = 101
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char = b;code = 98
char = l;code = 108
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char = N;code = 78
char = I;code = 73
char = H;code = 72
char = ;code = 32
char = 3;code = 51
char = T;code = 84
char = 3;code = 51
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char = e;code = 101
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char = b;code = 98
char = ;code = 32
char = B;code = 66
char = 2;code = 50
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char = e;code = 101
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char = o;code = 111
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = N;code = 78
char = I;code = 73
char = H;code = 72
char = ;code = 32
char = 3;code = 51
char = T;code = 84
char = 3;code = 51
char = ,;code = 44
char = ;code = 32
char = m;code = 109
char = o;code = 111
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char = s;code = 115
char = e;code = 101
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char = s;code = 115
char = a;code = 97
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char = c;code = 99
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char = m;code = 109
char = a;code = 97
char = ;code = 32
char = S;code = 83
char = 1;code = 49
char = 8;code = 56
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char = h;code = 104
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char = m;code = 109
char = a;code = 97
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char = c;code = 99
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char = l;code = 108
char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = H;code = 72
char = T;code = 84
char = -;code = 45
char = 2;code = 50
char = 9;code = 57
char = ,;code = 44
char = ;code = 32
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char = k;code = 107
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char = c;code = 99
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char = d;code = 100
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char = o;code = 111
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char = l;code = 108
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char = ;code = 32
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char = r;code = 114
char = c;code = 99
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char = a;code = 97
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = p;code = 112
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char = G;code = 71
char = 2;code = 50
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char = c;code = 99
char = e;code = 101
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char = s;code = 115
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char = ;code = 32
char = b;code = 98
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char = t;code = 116
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char = c;code = 99
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char = l;code = 108
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char = 1;code = 49
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result sql = Curcumin, which is a widely used dietary pigment and spice, has been demonstrated to be an effective inhibitor of tumor promotion in mouse skin carcinogenesis. We report that curcumin induces cell shrinkage, chromatin condensation, and DNA fragmentation, characteristics of apoptosis, in immortalized mouse embryo fibroblast NIH 3T3 erb B2 oncogene-transformed NIH 3T3, mouse sarcoma S180, human colon cancer cell HT-29, human kidney cancer cell 293, and human hepatocellular carcinoma Hep G2 cells, but not in primary culture of mouse embryonic fibroblast C3H 10T1/2, rat embryonic fibroblast, and human foreskin fibroblast cells in a concentration- and time-dependent manner. Many cellular and biochemical effects of curcumin in mouse fibroblast cells have been reported, such as inhibition of protein kinase C (PKC) activity induced by phorbol 12-myristate 13-acetate treatment, inhibition of tyrosine protein kinase activity, and inhibition of arachidonic acid (AA) metabolism. Treatment of NIH 3T3 cells with the PKC inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin A, and the AA metabolism inhibitor quinacrine induces apoptotic cell death. These results suggest that, in some immortalized and transformed cells, blocking the cellular signal transduction might trigger the induction of apoptosis.

Publication: Nutr Cancer 1996 ;26(1)::111-20.
Publication Date: 1996
Study Author(s): Jiang, M C;Yang-Yen, H F;Yen, J J;Lin, J K;
Institution: Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.
Shortcut link to this study:
Curcumin, which is a widely used dietary pigment and spice, has been demonstrated to be an effective inhibitor of tumor promotion in mouse skin carcinogenesis. We report that curcumin induces cell shrinkage, chromatin condensation, and DNA fragmentation, characteristics of apoptosis, in immortalized mouse embryo fibroblast NIH 3T3 erb B2 oncogene-transformed NIH 3T3, mouse sarcoma S180, human colon cancer cell HT-29, human kidney cancer cell 293, and human hepatocellular carcinoma Hep G2 cells, but not in primary culture of mouse embryonic fibroblast C3H 10T1/2, rat embryonic fibroblast, and human foreskin fibroblast cells in a concentration- and time-dependent manner. Many cellular and biochemical effects of curcumin in mouse fibroblast cells have been reported, such as inhibition of protein kinase C (PKC) activity induced by phorbol 12-myristate 13-acetate treatment, inhibition of tyrosine protein kinase activity, and inhibition of arachidonic acid (AA) metabolism. Treatment of NIH 3T3 cells with the PKC inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin A, and the AA metabolism inhibitor quinacrine induces apoptotic cell death. These results suggest that, in some immortalized and transformed cells, blocking the cellular signal transduction might trigger the induction of apoptosis.
PMID: 8844727

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