char = E;code = 69 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = n;code = 110 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = l;code = 108 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = (;code = 40 char = C;code = 67 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = p;code = 112 char = h;code = 104 char = u;code = 117 char = s;code = 115 char = );code = 41 char = .;code = 46 result sql = Effect of pregnancy and exogenous interferon on synchronous pulsatile release of oxytocin and luteolytic prostaglandin F2 alpha in red deer (Cervus elaphus).
Effect of pregnancy and exogenous interferon on synchronous pulsatile release of oxytocin and luteolytic prostaglandin F2 alpha in red deer (Cervus elaphus).char = T;code = 84 char = h;code = 104 char = r;code = 114 char = e;code = 101 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = r;code = 114 char = i;code = 105 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = v;code = 118 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = g;code = 103 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = h;code = 104 char = o;code = 111 char = r;code = 114 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = y;code = 121 char = c;code = 99 char = l;code = 108 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = t;code = 116 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = r;code = 114 char = e;code = 101 char = e;code = 101 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 8;code = 56 char = -;code = 45 char = 9;code = 57 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = );code = 41 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = -;code = 45 char = i;code = 105 char = m;code = 109 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = d;code = 100 char = r;code = 114 char = u;code = 117 char = g;code = 103 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = (;code = 40 char = C;code = 67 char = I;code = 73 char = D;code = 68 char = R;code = 82 char = );code = 41 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = 1;code = 49 char = 3;code = 51 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = d;code = 100 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = d;code = 100 char = r;code = 114 char = a;code = 97 char = w;code = 119 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 0;code = 48 char = );code = 41 char = .;code = 46 char = ;code = 32 char = G;code = 71 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 9;code = 57 char = );code = 41 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = s;code = 115 char = ;;code = 59 char = ;code = 32 char = G;code = 71 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = 2;code = 50 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 8;code = 56 char = );code = 41 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = j;code = 106 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 4;code = 52 char = ;code = 32 char = m;code = 109 char = g;code = 103 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = b;code = 98 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = v;code = 118 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = -;code = 45 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = w;code = 119 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = 1;code = 49 char = 3;code = 51 char = -;code = 45 char = 1;code = 49 char = 8;code = 56 char = ;;code = 59 char = ;code = 32 char = G;code = 71 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 9;code = 57 char = );code = 41 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = u;code = 117 char = n;code = 110 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = 0;code = 48 char = -;code = 45 char = 3;code = 51 char = .;code = 46 char = ;code = 32 char = P;code = 80 char = l;code = 108 char = a;code = 97 char = s;code = 115 char = m;code = 109 char = a;code = 97 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = a;code = 97 char = c;code = 99 char = h;code = 104 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = 1;code = 49 char = 6;code = 54 char = -;code = 45 char = 2;code = 50 char = 3;code = 51 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = y;code = 121 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = .;code = 46 char = ;code = 32 char = P;code = 80 char = l;code = 108 char = a;code = 97 char = s;code = 115 char = m;code = 109 char = a;code = 97 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = a;code = 97 char = c;code = 99 char = h;code = 104 char = ;code = 32 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = r;code = 114 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = 1;code = 49 char = 6;code = 54 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = 4;code = 52 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = 6;code = 54 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = 8;code = 56 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = y;code = 121 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = l;code = 108 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = G;code = 71 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = );code = 41 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = t;code = 116 char = a;code = 97 char = b;code = 98 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = G;code = 71 char = F;code = 70 char = M;code = 77 char = );code = 41 char = .;code = 46 char = ;code = 32 char = P;code = 80 char = l;code = 108 char = a;code = 97 char = s;code = 115 char = m;code = 109 char = a;code = 97 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = -;code = 45 char = 1;code = 49 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = 1;code = 49 char = 8;code = 56 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 2;code = 50 char = 5;code = 53 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = c;code = 99 char = c;code = 99 char = u;code = 117 char = r;code = 114 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = ;code = 32 char = e;code = 101 char = n;code = 110 char = d;code = 100 char = o;code = 111 char = c;code = 99 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = C;code = 67 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = 6;code = 54 char = /;code = 47 char = 9;code = 57 char = );code = 41 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = h;code = 104 char = i;code = 105 char = b;code = 98 char = i;code = 105 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = n;code = 110 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = P;code = 80 char = G;code = 71 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 8;code = 56 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ,;code = 44 char = ;code = 32 char = c;code = 99 char = l;code = 108 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = n;code = 110 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = P;code = 80 char = G;code = 71 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = u;code = 117 char = n;code = 110 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = h;code = 104 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 2;code = 50 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 8;code = 56 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = r;code = 114 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ,;code = 44 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = P;code = 80 char = G;code = 71 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 1;code = 49 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = h;code = 104 char = i;code = 105 char = b;code = 98 char = i;code = 105 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = 6;code = 54 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = u;code = 117 char = l;code = 108 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = g;code = 103 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = n;code = 110 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = P;code = 80 char = G;code = 71 char = F;code = 70 char = 2;code = 50 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = p;code = 112 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = n;code = 110 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = .;code = 46 char = ;code = 32 char = O;code = 79 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = x;code = 120 char = y;code = 121 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = u;code = 117 char = n;code = 110 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = l;code = 108 char = i;code = 105 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = y;code = 121 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = h;code = 104 char = o;code = 111 char = r;code = 114 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = e;code = 101 char = r;code = 114 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = Three experiments were carried out to investigate the secretion of luteolytic hormones in red deer hinds during the oestrous cycle, early pregnancy and after administration of interferon, the putative pregnancy recognition signal. Three groups of hinds (n = 8-9 per group) were treated with progesterone-impregnated intravaginal controlled internal drug releasing (CIDR) devices for 13 days (device withdrawal = day 0). Group 1 (n = 9) served as controls; Group 2 (n = 8) received injections of 4 mg recombinant bovine interferon-alpha 1 l twice a day on days 13-18; Group 3 (n = 9) were run with a fertile stag on days 0-3. Plasma samples collected each day on days 16-23 were analysed for progesterone. Plasma samples collected each hour for 16 h on days 4, 10, 16, 18 were analysed for oxytocin and the prostaglandin F2 alpha (PGF2 alpha) metabolite (PGFM). Plasma progesterone concentrations declined to < 1 ng ml-1 between days 18 and 25 in control hinds indicating that luteolysis had occurred, whereas there was no endocrine evidence of luteolysis in interferon-treated or pregnant hinds. Control hinds (6/9) exhibited synchronous pulses of oxytocin and PGF2 alpha secretion on day 18, a greater proportion than on any other day in these hinds or on any day in the interferon-treated or mated hinds (P < 0.05). In a second experiment, close synchrony in secretion of oxytocin and PGF2 alpha pulses was evident in an unmated hind when samples were collected every 12 min on day 18. In a third experiment, oxytocin-induced PGF2 alpha secretion was potentiated by oxytocin administration at an interval of 1 h and inhibited by administration at a 6 h interval (P < 0.05). These results suggest that synchronous pulsatile secretion of oxytocin and PGF2 alpha induces luteolysis and is suppressed by pregnancy or administration of interferon. Oxytocin-induced alterations in uterine oxytocin sensitivity may underlie the pulsatile nature of luteolytic hormone secretion in red deer.
Publication: J. Reprod. Fertil. 1997 Nov ;111(2)::299-307.
Publication Date: 1997 Nov
Study Author(s): Bainbridge, D R;Jabbour, H N;
Institution: Zoological Society of London, Institute of Zoology, UK.
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Three experiments were carried out to investigate the secretion of luteolytic hormones in red deer hinds during the oestrous cycle, early pregnancy and after administration of interferon, the putative pregnancy recognition signal. Three groups of hinds (n = 8-9 per group) were treated with progesterone-impregnated intravaginal controlled internal drug releasing (CIDR) devices for 13 days (device withdrawal = day 0). Group 1 (n = 9) served as controls; Group 2 (n = 8) received injections of 4 mg recombinant bovine interferon-alpha 1 l twice a day on days 13-18; Group 3 (n = 9) were run with a fertile stag on days 0-3. Plasma samples collected each day on days 16-23 were analysed for progesterone. Plasma samples collected each hour for 16 h on days 4, 10, 16, 18 were analysed for oxytocin and the prostaglandin F2 alpha (PGF2 alpha) metabolite (PGFM). Plasma progesterone concentrations declined to < 1 ng ml-1 between days 18 and 25 in control hinds indicating that luteolysis had occurred, whereas there was no endocrine evidence of luteolysis in interferon-treated or pregnant hinds. Control hinds (6/9) exhibited synchronous pulses of oxytocin and PGF2 alpha secretion on day 18, a greater proportion than on any other day in these hinds or on any day in the interferon-treated or mated hinds (P < 0.05). In a second experiment, close synchrony in secretion of oxytocin and PGF2 alpha pulses was evident in an unmated hind when samples were collected every 12 min on day 18. In a third experiment, oxytocin-induced PGF2 alpha secretion was potentiated by oxytocin administration at an interval of 1 h and inhibited by administration at a 6 h interval (P < 0.05). These results suggest that synchronous pulsatile secretion of oxytocin and PGF2 alpha induces luteolysis and is suppressed by pregnancy or administration of interferon. Oxytocin-induced alterations in uterine oxytocin sensitivity may underlie the pulsatile nature of luteolytic hormone secretion in red deer.
PMID: 9462299