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char = r;code = 114
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = r;code = 114
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char = a;code = 97
char = l;code = 108
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char = t;code = 116
char = y;code = 121
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char = e;code = 101
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char = t;code = 116
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char = m;code = 109
char = a;code = 97
char = c;code = 99
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char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
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char = t;code = 116
char = r;code = 114
char = y;code = 121
char = .;code = 46
result sql = Dose-response associations of silica with nonmalignant respiratory disease and lung cancer mortality in the diatomaceous earth industry.
Dose-response associations of silica with nonmalignant respiratory disease and lung cancer mortality in the diatomaceous earth industry.
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result sql = The potential carcinogenicity of crystalline silica to humans remains a controversial issue. The authors conducted an historical cohort mortality study of 2,342 male workers exposed to crystalline silica, predominantly cristobalite, in a diatomaceous earth mining and processing facility in California. During the years 1942-1994, mortality excesses were detected for nonmalignant respiratory diseases (NMRD) (standardized mortality ratio = 2.01, 95% confidence interval (CI) 1.56-2.55) and lung cancer (standardized mortality ratio = 1.29, 95% CI 1.01-1.61) NMRD : mortality rose sharply with cumulative exposure to respirable crystalline silica; allowing for a 15-year latency, the rate ratio for the highest exposure stratum (> or = 5.0 mg/m3-years) was 5.35 (95% CI 2.23-12.8). The rate ratio for lung cancer reached 2.15 (95% CI 1.08-4.28) in the highest exposure category. These associations were unlikely to have been confounded by smoking or asbestos exposure. The findings indicate a strong dose-response relation for crystalline silica and NMRD mortality. The lung cancer results, although less convincing, add further support to an etiologic role for crystalline silica.

Publication: Am. J. Epidemiol. 1997 Apr 15 ;145(8)::680-8.
Publication Date: 1997 Apr 15
Study Author(s): Checkoway, H;Heyer, N J;Seixas, N S;Welp, E A;Demers, P A;Hughes, J M;Weill, H;
Institution: Department of Environmental Health, University of Washington, Seattle 98195-7234, USA.
Shortcut link to this study:
The potential carcinogenicity of crystalline silica to humans remains a controversial issue. The authors conducted an historical cohort mortality study of 2,342 male workers exposed to crystalline silica, predominantly cristobalite, in a diatomaceous earth mining and processing facility in California. During the years 1942-1994, mortality excesses were detected for nonmalignant respiratory diseases (NMRD) (standardized mortality ratio = 2.01, 95% confidence interval (CI) 1.56-2.55) and lung cancer (standardized mortality ratio = 1.29, 95% CI 1.01-1.61) NMRD : mortality rose sharply with cumulative exposure to respirable crystalline silica; allowing for a 15-year latency, the rate ratio for the highest exposure stratum (> or = 5.0 mg/m3-years) was 5.35 (95% CI 2.23-12.8). The rate ratio for lung cancer reached 2.15 (95% CI 1.08-4.28) in the highest exposure category. These associations were unlikely to have been confounded by smoking or asbestos exposure. The findings indicate a strong dose-response relation for crystalline silica and NMRD mortality. The lung cancer results, although less convincing, add further support to an etiologic role for crystalline silica.
PMID: 9125994

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