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result sql = Calcium channel blockers: association with myocardial infarction, mortality, and cancer.
Calcium channel blockers: association with myocardial infarction, mortality, and cancer.
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char = n;code = 110
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char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = u;code = 117
char = n;code = 110
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char = l;code = 108
char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = g;code = 103
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char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = P;code = 80
char = r;code = 114
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char = t;code = 116
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char = s;code = 115
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char = h;code = 104
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char = c;code = 99
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char = i;code = 105
char = b;code = 98
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char = n;code = 110
char = g;code = 103
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char = C;code = 67
char = B;code = 66
char = s;code = 115
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char = ;code = 32
char = p;code = 112
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char = (;code = 40
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char = t;code = 116
char = h;code = 104
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char = c;code = 99
char = o;code = 111
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char = s;code = 115
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char = r;code = 114
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char = l;code = 108
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char = ;code = 32
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char = l;code = 108
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char = c;code = 99
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char = ;code = 32
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char = b;code = 98
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char = n;code = 110
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char = c;code = 99
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char = o;code = 111
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char = y;code = 121
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = e;code = 101
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = d;code = 100
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char = s;code = 115
char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = );code = 41
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = o;code = 111
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char = s;code = 115
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char = b;code = 98
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char = n;code = 110
char = g;code = 103
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char = C;code = 67
char = B;code = 66
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
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char = l;code = 108
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
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result sql = The purpose of this study was to review the results of trials assessing the association between the use of calcium channel blockers (CCBs) and mortality, myocardial infarction (MI), and cancer. Possible mechanisms of such relationships are discussed and recommendations regarding the use of CCBs made. Since 1995, 10 controversial studies have been published that associate the use of CCBs with an increased risk of mortality, MI, and cancer; these findings have caused widespread anxiety and frustration among patients and physicians. For health care professionals to properly advise patients, the facts surrounding this controversy should be reviewed. To do this, we reviewed and assessed English-language clinical studies, abstracts, editorials, and review articles pertaining to the use of CCBs and mortality, MI, and cancer in humans. The designs of ongoing prospective, randomized studies are discussed. Based on current published studies, the US Food and Drug Administration has agreed to a label warning against off-label use of short-acting nifedipine in patients with hypertension, acute MI, or nonvasospastic unstable angina. Practitioners should exercise caution when prescribing CCBs, especially to high-risk patients (e.g., those with congestive heart failure or clinical or subclinical coronary artery disease). When possible, long-acting CCBs should be used.

Publication: Clin Ther 1997 Nov-Dec ;19(6)::1255-68; discussion 1253-4.
Publication Date: 1997 Nov-Dec
Study Author(s): Cheng, J W;Behar, L;
Institution: Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York, USA.
Shortcut link to this study:
The purpose of this study was to review the results of trials assessing the association between the use of calcium channel blockers (CCBs) and mortality, myocardial infarction (MI), and cancer. Possible mechanisms of such relationships are discussed and recommendations regarding the use of CCBs made. Since 1995, 10 controversial studies have been published that associate the use of CCBs with an increased risk of mortality, MI, and cancer; these findings have caused widespread anxiety and frustration among patients and physicians. For health care professionals to properly advise patients, the facts surrounding this controversy should be reviewed. To do this, we reviewed and assessed English-language clinical studies, abstracts, editorials, and review articles pertaining to the use of CCBs and mortality, MI, and cancer in humans. The designs of ongoing prospective, randomized studies are discussed. Based on current published studies, the US Food and Drug Administration has agreed to a label warning against off-label use of short-acting nifedipine in patients with hypertension, acute MI, or nonvasospastic unstable angina. Practitioners should exercise caution when prescribing CCBs, especially to high-risk patients (e.g., those with congestive heart failure or clinical or subclinical coronary artery disease). When possible, long-acting CCBs should be used.
PMID: 9444438

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