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char = ?;code = 63
result sql = Selenium, calcium channel blockers, and cancer risk--the Yin and Yang of apoptosis?
Selenium, calcium channel blockers, and cancer risk--the Yin and Yang of apoptosis?
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char = G;code = 71
char = F;code = 70
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char = t;code = 116
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char = ;code = 32
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char = g;code = 103
char = h;code = 104
char = -;code = 45
char = d;code = 100
char = o;code = 111
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char = e;code = 101
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char = a;code = 97
char = m;code = 109
char = o;code = 111
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = p;code = 112
char = r;code = 114
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char = t;code = 116
char = e;code = 101
char = i;code = 105
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char = C;code = 67
char = ;code = 32
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char = a;code = 97
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char = i;code = 105
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char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = d;code = 100
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char = a;code = 97
char = w;code = 119
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char = l;code = 108
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char = o;code = 111
char = c;code = 99
char = k;code = 107
char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = t;code = 116
char = r;code = 114
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char = p;code = 112
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char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = s;code = 115
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char = i;code = 105
char = m;code = 109
char = o;code = 111
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char = e;code = 101
char = n;code = 110
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char = t;code = 116
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char = i;code = 105
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char = f;code = 102
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char = a;code = 97
char = l;code = 108
char = o;code = 111
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char = ,;code = 44
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char = ;code = 32
char = f;code = 102
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char = i;code = 105
char = u;code = 117
char = m;code = 109
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char = b;code = 98
char = u;code = 117
char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = m;code = 109
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char = e;code = 101
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
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result sql = It is increasingly clear that apoptosis plays a crucial role in the promotional phase of cancer development. Initiated pre-neoplastic clones in rat liver experience a high rate of apoptosis, and this rate has an important impact on the survival and growth of these clones. Suppression of apoptosis appears to be a universal property of cancer promoters, suggesting conversely that agents which inhibit cancer induction during the promotional phase increase the rate of apoptosis in initiated cells. Modulation of apoptosis is a likely explanation for recent striking evidence that use of calcium channel blockers substantially increases, whereas supplemental selenium substantially decreases, human cancer incidence. Non-genotoxic measures which are likely to upregulate apoptosis in pre-neoplastic/neoplastic cells--and thus may be useful in prevention and/or therapy--include selenium, retinoids/carotenoids, green tea polyphenols, caloric restriction, downregulation of IGF-I activity, high-dose tamoxifen and other protein kinase C antagonists, withdrawal or blockade of trophic hormones, isoflavones, limonene, vitamin D and cholecalciferol analogs, dietary fiber/sodium butyrate, hyperthermia, benzaldehyde derivatives, and creatine.

Publication: Med. Hypotheses 1998 May ;50(5)::423-33.
Publication Date: 1998 May
Study Author(s): McCarty, M F;
Institution: Nutrition 21, San Diego, CA 92109, USA.
Shortcut link to this study:
It is increasingly clear that apoptosis plays a crucial role in the promotional phase of cancer development. Initiated pre-neoplastic clones in rat liver experience a high rate of apoptosis, and this rate has an important impact on the survival and growth of these clones. Suppression of apoptosis appears to be a universal property of cancer promoters, suggesting conversely that agents which inhibit cancer induction during the promotional phase increase the rate of apoptosis in initiated cells. Modulation of apoptosis is a likely explanation for recent striking evidence that use of calcium channel blockers substantially increases, whereas supplemental selenium substantially decreases, human cancer incidence. Non-genotoxic measures which are likely to upregulate apoptosis in pre-neoplastic/neoplastic cells--and thus may be useful in prevention and/or therapy--include selenium, retinoids/carotenoids, green tea polyphenols, caloric restriction, downregulation of IGF-I activity, high-dose tamoxifen and other protein kinase C antagonists, withdrawal or blockade of trophic hormones, isoflavones, limonene, vitamin D and cholecalciferol analogs, dietary fiber/sodium butyrate, hyperthermia, benzaldehyde derivatives, and creatine.
PMID: 9681923

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