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char = .;code = 46
result sql = Nested case-control study of esophageal cancer in relation to occupational exposure to silica and other dusts.
Nested case-control study of esophageal cancer in relation to occupational exposure to silica and other dusts.
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char = r;code = 114
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char = N;code = 78
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char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = h;code = 104
char = i;code = 105
char = p;code = 112
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = c;code = 99
char = c;code = 99
char = u;code = 117
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = e;code = 101
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char = p;code = 112
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char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = u;code = 117
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = E;code = 69
char = C;code = 67
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = r;code = 114
char = l;code = 108
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char = e;code = 101
char = r;code = 114
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char = P;code = 80
char = M;code = 77
char = R;code = 82
char = ;code = 32
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char = t;code = 116
char = u;code = 117
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char = a;code = 97
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char = o;code = 111
char = n;code = 110
char = f;code = 102
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char = r;code = 114
char = m;code = 109
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char = e;code = 101
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char = l;code = 108
char = u;code = 117
char = n;code = 110
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char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = ;code = 32
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char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = i;code = 105
char = s;code = 115
char = k;code = 107
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = E;code = 69
char = C;code = 67
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = w;code = 119
char = o;code = 111
char = r;code = 114
char = k;code = 107
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
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char = i;code = 105
char = l;code = 108
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result sql = BACKGROUND : Standardized proportionate mortality ratio (SPMR) was found to be 2.2 (95% CI = 1.3-3.5) for esophageal cancer (EC) among workers exposed to refractory brick dust in a large iron-steel complex in China.

METHODS : A nested case-control design within a cohort of industrial workers. One hundred and twenty-five EC cases and 250 controls were identified from the death registry file. Interviews were conducted of the next of kin for past exposure information on job, domestic, and lifestyle factors. History of occupational exposure to various dusts was reconstructed from personnel files and by interviewing colleagues utilizing a job-exposure matrix.

RESULTS : After adjusting for confounders, occupational exposure to silica dust was the most important risk factor among all variables investigated, with a 2.8-fold risk and a clear dose-response by length of exposure. Alcohol drinking (OR = 1.8) and coal cooking (OR = 2.0) were risk factors and high consumption of fruit diet (OR = 0.5) and meat diet (OR = 0.6) were protective factors.

CONCLUSIONS : The relationship between occupational exposure to silica dust and the risk of EC found in an earlier SPMR study was confirmed. Ingestion of silica particles after lung clearance may increase the risk of EC among workers exposed to silica.

Publication: Am. J. Ind. Med. 1999 Mar ;35(3)::272-80.
Publication Date: 1999 Mar
Study Author(s): Pan, G;Takahashi, K;Feng, Y;Liu, L;Liu, T;Zhang, S;Liu, N;Okubo, T;Goldsmith, D F;
Institution: Environmental Epidemiology Branch, Liaoning Public Health and Anti-epidemic Station, Shenyang City, P.R. China. [email protected]
Shortcut link to this study:
BACKGROUND : Standardized proportionate mortality ratio (SPMR) was found to be 2.2 (95% CI = 1.3-3.5) for esophageal cancer (EC) among workers exposed to refractory brick dust in a large iron-steel complex in China.

METHODS : A nested case-control design within a cohort of industrial workers. One hundred and twenty-five EC cases and 250 controls were identified from the death registry file. Interviews were conducted of the next of kin for past exposure information on job, domestic, and lifestyle factors. History of occupational exposure to various dusts was reconstructed from personnel files and by interviewing colleagues utilizing a job-exposure matrix.

RESULTS : After adjusting for confounders, occupational exposure to silica dust was the most important risk factor among all variables investigated, with a 2.8-fold risk and a clear dose-response by length of exposure. Alcohol drinking (OR = 1.8) and coal cooking (OR = 2.0) were risk factors and high consumption of fruit diet (OR = 0.5) and meat diet (OR = 0.6) were protective factors.

CONCLUSIONS : The relationship between occupational exposure to silica dust and the risk of EC found in an earlier SPMR study was confirmed. Ingestion of silica particles after lung clearance may increase the risk of EC among workers exposed to silica.
PMID: 9987560

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