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char = y;code = 121
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char = z;code = 122
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char = s;code = 115
char = t;code = 116
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = N;code = 78
char = i;code = 105
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char = d;code = 100
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char = #;code = 35
char = 2;code = 50
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char = o;code = 111
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = u;code = 117
char = x;code = 120
char = .;code = 46
result sql = Mercury water and cauterizing stones: Nicolas André and tic douloureux.
Mercury water and cauterizing stones: Nicolas André and tic douloureux.
char = I;code = 73
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char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = 6;code = 54
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char = t;code = 116
char = e;code = 101
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char = t;code = 116
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char = ;code = 32
char = O;code = 79
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char = e;code = 101
char = r;code = 114
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = i;code = 105
char = q;code = 113
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char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = ;code = 32
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char = e;code = 101
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char = m;code = 109
char = a;code = 97
char = l;code = 108
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = ;code = 32
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char = s;code = 115
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char = f;code = 102
char = a;code = 97
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char = t;code = 116
char = s;code = 115
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char = s;code = 115
char = i;code = 105
char = f;code = 102
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char = ,;code = 44
char = ;code = 32
char = N;code = 78
char = i;code = 105
char = c;code = 99
char = o;code = 111
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char = a;code = 97
char = s;code = 115
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char = A;code = 65
char = n;code = 110
char = d;code = 100
char = r;code = 114
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char = #;code = 35
char = 2;code = 50
char = 3;code = 51
char = 3;code = 51
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char = ;code = 32
char = c;code = 99
char = o;code = 111
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = ";code = 34
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = u;code = 117
char = l;code = 108
char = o;code = 111
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = u;code = 117
char = x;code = 120
char = .;code = 46
char = ";code = 34
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
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char = i;code = 105
char = s;code = 115
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char = p;code = 112
char = a;code = 97
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char = ;code = 32
char = o;code = 111
char = r;code = 114
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char = g;code = 103
char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
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char = n;code = 110
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = y;code = 121
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char = e;code = 101
char = r;code = 114
char = i;code = 105
char = p;code = 112
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char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = v;code = 118
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = U;code = 85
char = s;code = 115
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = b;code = 98
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char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = f;code = 102
char = u;code = 117
char = l;code = 108
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = u;code = 117
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = u;code = 117
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = B;code = 66
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char = e;code = 101
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
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char = o;code = 111
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char = ;code = 32
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char = l;code = 108
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char = r;code = 114
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = b;code = 98
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char = n;code = 110
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char = t;code = 116
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char = i;code = 105
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char = c;code = 99
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char = A;code = 65
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char = 3;code = 51
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char = n;code = 110
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char = b;code = 98
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char = o;code = 111
char = p;code = 112
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char = o;code = 111
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char = n;code = 110
char = d;code = 100
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char = a;code = 97
char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = e;code = 101
char = .;code = 46
char = ;code = 32
char = A;code = 65
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char = d;code = 100
char = r;code = 114
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char = #;code = 35
char = 2;code = 50
char = 3;code = 51
char = 3;code = 51
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char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = r;code = 114
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char = c;code = 99
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char = l;code = 108
char = ;code = 32
char = t;code = 116
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char = c;code = 99
char = h;code = 104
char = n;code = 110
char = i;code = 105
char = q;code = 113
char = u;code = 117
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = u;code = 117
char = s;code = 115
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = z;code = 122
char = i;code = 105
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char = ;code = 32
char = s;code = 115
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char = ;code = 32
char = e;code = 101
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char = s;code = 115
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char = d;code = 100
char = a;code = 97
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char = l;code = 108
char = s;code = 115
char = ;code = 32
char = f;code = 102
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char = u;code = 117
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char = o;code = 111
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char = e;code = 101
char = d;code = 100
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char = l;code = 108
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char = g;code = 103
char = u;code = 117
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
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char = h;code = 104
char = o;code = 111
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char = r;code = 114
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char = m;code = 109
char = e;code = 101
char = m;code = 109
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = w;code = 119
char = o;code = 111
char = ;code = 32
char = w;code = 119
char = o;code = 111
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char = s;code = 115
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char = c;code = 99
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char = l;code = 108
char = o;code = 111
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char = r;code = 114
char = e;code = 101
char = u;code = 117
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char = ";code = 34
char = ;code = 32
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char = i;code = 105
char = c;code = 99
char = o;code = 111
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char = a;code = 97
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char = ;code = 32
char = A;code = 65
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char = d;code = 100
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char = s;code = 115
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char = g;code = 103
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char = e;code = 101
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char = n;code = 110
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char = d;code = 100
char = ;code = 32
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char = o;code = 111
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char = ;code = 32
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = c;code = 99
char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = t;code = 116
char = r;code = 114
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char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
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char = t;code = 116
char = ;code = 32
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char = d;code = 100
char = ;code = 32
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char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = i;code = 105
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char = i;code = 105
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = a;code = 97
char = ;code = 32
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char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = d;code = 100
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char = f;code = 102
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
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char = /;code = 47
char = >;code = 62
result sql = In his 1756 text, Observations pratiques sur les maladies de l'urèthre et sur plusiers faits convulsifs, Nicolas André coined the term "tic douloureux." He believed that this pain originated from compression of facial sensory peripheral nerves. Using scientific observation and experimentation to confirm this hypothesis, he reproduced the tic pain and treated it by using careful efforts to remove adhesions from the nerve with a caustic solution of mercury water. Believing that recurrence of the pain was a result of early closure of the wound, with recompression of the nerve being the direct cause, André prevented recompression by ensuring open wound drainage. André's surgical technique of using cauterizing stones ensured that there was minimal blood loss and little danger of rebleeding and recompression of the nerve by an accumulated blood clot. His case reports include lengthy follow-up periods that documented the benefits of his procedures, which were confirmed by testimonials from uninvolved colleagues. Although remembered for the two words, "tic douloureux," Nicolas André has long been ignored for his prescient treatment and scientific analysis of a disease for which the modern standard of care has only been defined during the last generation.

Publication: J. Neurosurg. 1999 May ;90(5)::977-81.
Publication Date: 1999 May
Study Author(s): Brown, J A;Coursaget, C;Preul, M C;Sangvai, D;
Institution: Department of Neurological Surgery, Medical College of Ohio, Toledo 43614, USA. [email protected]
Shortcut link to this study:
In his 1756 text, Observations pratiques sur les maladies de l'urèthre et sur plusiers faits convulsifs, Nicolas André coined the term "tic douloureux." He believed that this pain originated from compression of facial sensory peripheral nerves. Using scientific observation and experimentation to confirm this hypothesis, he reproduced the tic pain and treated it by using careful efforts to remove adhesions from the nerve with a caustic solution of mercury water. Believing that recurrence of the pain was a result of early closure of the wound, with recompression of the nerve being the direct cause, André prevented recompression by ensuring open wound drainage. André's surgical technique of using cauterizing stones ensured that there was minimal blood loss and little danger of rebleeding and recompression of the nerve by an accumulated blood clot. His case reports include lengthy follow-up periods that documented the benefits of his procedures, which were confirmed by testimonials from uninvolved colleagues. Although remembered for the two words, "tic douloureux," Nicolas André has long been ignored for his prescient treatment and scientific analysis of a disease for which the modern standard of care has only been defined during the last generation.
PMID: 10223470

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