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char = n;code = 110
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char = .;code = 46
result sql = Vitamin D receptor expression in colorectal cancer.
Vitamin D receptor expression in colorectal cancer.
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char = ;code = 32
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char = e;code = 101
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char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = b;code = 98
char = >;code = 62
char = P;code = 80
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char = r;code = 114
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char = f;code = 102
char = f;code = 102
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char = n;code = 110
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char = r;code = 114
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char = t;code = 116
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char = y;code = 121
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char = u;code = 117
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char = n;code = 110
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char = ;code = 32
char = t;code = 116
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char = y;code = 121
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char = 9;code = 57
char = A;code = 65
char = 7;code = 55
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char = g;code = 103
char = a;code = 97
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char = a;code = 97
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char = c;code = 99
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char = ;code = 32
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char = a;code = 97
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char = n;code = 110
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char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = c;code = 99
char = e;code = 101
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char = t;code = 116
char = o;code = 111
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = (;code = 40
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char = t;code = 116
char = i;code = 105
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char = t;code = 116
char = i;code = 105
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result sql = AIMS : To determine whether the vitamin D receptor is expressed in colorectal cancer, and its relation to stage of disease.

METHODS : Paraffin embedded sections of colorectal cancer from 30 patients who had undergone surgery were studied. Immunohistochemistry using the specific monoclonal antibody 9A7 gamma directed against the nuclear vitamin D receptor was used to identify receptors for the active metabolite of vitamin D3 (1,25-dihydroxyvitamin D3).

RESULTS : Microscopically normal human colorectal epithelium showed vitamin D receptor expression predominantly in the mid and upper crypts. All the colorectal cancer tissue studied showed vitamin D receptor expression, with a median of 25.3 (range 10.1 to 43.7) cells/graticule field (x 400). Although vitamin D receptor staining was heterogeneous within the individual cancers, neither Dukes stage nor the degree of differentiation appeared to influence expression of the receptor.

CONCLUSIONS : Colorectal cancer tissue expresses the nuclear vitamin D receptor and this could act as a potential therapeutic target for synthetic vitamin D3 differentiating agents.

Publication: J. Clin. Pathol. 1999 Mar ;52(3)::181-3.
Publication Date: 1999 Mar
Study Author(s): Thomas, M G;Sylvester, P A;Newcomb, P;Longman, R J;
Institution: Academic Department of Surgery, Bristol Royal Infirmary, Bristol, UK.
Shortcut link to this study:
AIMS : To determine whether the vitamin D receptor is expressed in colorectal cancer, and its relation to stage of disease.

METHODS : Paraffin embedded sections of colorectal cancer from 30 patients who had undergone surgery were studied. Immunohistochemistry using the specific monoclonal antibody 9A7 gamma directed against the nuclear vitamin D receptor was used to identify receptors for the active metabolite of vitamin D3 (1,25-dihydroxyvitamin D3).

RESULTS : Microscopically normal human colorectal epithelium showed vitamin D receptor expression predominantly in the mid and upper crypts. All the colorectal cancer tissue studied showed vitamin D receptor expression, with a median of 25.3 (range 10.1 to 43.7) cells/graticule field (x 400). Although vitamin D receptor staining was heterogeneous within the individual cancers, neither Dukes stage nor the degree of differentiation appeared to influence expression of the receptor.

CONCLUSIONS : Colorectal cancer tissue expresses the nuclear vitamin D receptor and this could act as a potential therapeutic target for synthetic vitamin D3 differentiating agents.
PMID: 10450176

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