|
|
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result sql = Nitric oxide and the oxytocin system in pregnancy.
Nitric oxide and the oxytocin system in pregnancy.char = W;code = 87
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char = t;code = 116
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char = l;code = 108
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char = g;code = 103
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char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ,;code = 44
char = ;code = 32
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char = f;code = 102
char = l;code = 108
char = e;code = 101
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char = a;code = 97
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char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = e;code = 101
char = x;code = 120
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char = r;code = 114
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char = m;code = 109
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char = e;code = 101
char = ;code = 32
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char = e;code = 101
char = u;code = 117
char = r;code = 114
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char = n;code = 110
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
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char = a;code = 97
char = c;code = 99
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char = o;code = 111
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char = ;code = 32
char = N;code = 78
char = O;code = 79
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char = n;code = 110
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char = i;code = 105
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char = o;code = 111
char = n;code = 110
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char = s;code = 115
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char = i;code = 105
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = u;code = 117
char = s;code = 115
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char = e;code = 101
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char = o;code = 111
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char = e;code = 101
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char = o;code = 111
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char = n;code = 110
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char = r;code = 114
char = e;code = 101
char = l;code = 108
char = e;code = 101
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char = e;code = 101
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char = ;code = 32
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char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = d;code = 100
char = o;code = 111
char = w;code = 119
char = n;code = 110
char = r;code = 114
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char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = u;code = 117
char = s;code = 115
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char = t;code = 116
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char = e;code = 101
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char = s;code = 115
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char = s;code = 115
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char = m;code = 109
char = ;code = 32
char = t;code = 116
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char = g;code = 103
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = e;code = 101
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result sql = We examined the functional role of the nitric oxide (NO)-producing system in magnocellular neurons and how this changes at the end of pregnancy, using a combination of blood sampling and oxytocin radioimmunoassay, electrophysiology, immunocytochemistry for Fos expression, and in situ hybridization histochemistry. In urethane-anesthetized virgin rats, systemic administration of NO synthase (NOS) inhibitors led to a facilitation of oxytocin release evoked by hyperosmotic stimulation. Direct application of the NO donor sodium nitroprusside to the supraoptic nucleus by in vivo microdialysis inhibited the electrical activity of both oxytocin neurons and vasopressin neurons, whereas direct application of an NOS inhibitor increased electrical activity, indicating that endogenous NO acts within the supraoptic nucleus to inhibit neuronal activity. However, during late pregnancy, the influence of endogenous NO is dramatically downregulated, reflected by a reduced expression of neuronal NOS mRNA in these neurons and a loss of efficacy of NOS inhibitors on stimulus-evoked oxytocin release. This downregulation may cause the oxytocin system to become more excitable at term, resulting in the capacity for greater release of oxytocin during parturition.
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = c;code = 99
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char = x;code = 120
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char = d;code = 100
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = o;code = 111
char = x;code = 120
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = c;code = 99
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char = y;code = 121
char = s;code = 115
char = t;code = 116
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char = m;code = 109
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
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char = g;code = 103
char = n;code = 110
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = .;code = 46
result sql = Nitric oxide and the oxytocin system in pregnancy.
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result sql = We examined the functional role of the nitric oxide (NO)-producing system in magnocellular neurons and how this changes at the end of pregnancy, using a combination of blood sampling and oxytocin radioimmunoassay, electrophysiology, immunocytochemistry for Fos expression, and in situ hybridization histochemistry. In urethane-anesthetized virgin rats, systemic administration of NO synthase (NOS) inhibitors led to a facilitation of oxytocin release evoked by hyperosmotic stimulation. Direct application of the NO donor sodium nitroprusside to the supraoptic nucleus by in vivo microdialysis inhibited the electrical activity of both oxytocin neurons and vasopressin neurons, whereas direct application of an NOS inhibitor increased electrical activity, indicating that endogenous NO acts within the supraoptic nucleus to inhibit neuronal activity. However, during late pregnancy, the influence of endogenous NO is dramatically downregulated, reflected by a reduced expression of neuronal NOS mRNA in these neurons and a loss of efficacy of NOS inhibitors on stimulus-evoked oxytocin release. This downregulation may cause the oxytocin system to become more excitable at term, resulting in the capacity for greater release of oxytocin during parturition.
Publication: J. Neurosci. 2000 Sep 1 ;20(17)::6721-7.
Publication Date: 2000 Sep 1
Study Author(s): Srisawat, R;Ludwig, M;Bull, P M;Douglas, A J;Russell, J A;Leng, G;
Institution: Department of Biomedical Sciences, University of Edinburgh Medical School, Edinburgh EH8 9XD, United Kingdom.
Shortcut link to this study:
Publication Date: 2000 Sep 1
Study Author(s): Srisawat, R;Ludwig, M;Bull, P M;Douglas, A J;Russell, J A;Leng, G;
Institution: Department of Biomedical Sciences, University of Edinburgh Medical School, Edinburgh EH8 9XD, United Kingdom.
Shortcut link to this study:
We examined the functional role of the nitric oxide (NO)-producing system in magnocellular neurons and how this changes at the end of pregnancy, using a combination of blood sampling and oxytocin radioimmunoassay, electrophysiology, immunocytochemistry for Fos expression, and in situ hybridization histochemistry. In urethane-anesthetized virgin rats, systemic administration of NO synthase (NOS) inhibitors led to a facilitation of oxytocin release evoked by hyperosmotic stimulation. Direct application of the NO donor sodium nitroprusside to the supraoptic nucleus by in vivo microdialysis inhibited the electrical activity of both oxytocin neurons and vasopressin neurons, whereas direct application of an NOS inhibitor increased electrical activity, indicating that endogenous NO acts within the supraoptic nucleus to inhibit neuronal activity. However, during late pregnancy, the influence of endogenous NO is dramatically downregulated, reflected by a reduced expression of neuronal NOS mRNA in these neurons and a loss of efficacy of NOS inhibitors on stimulus-evoked oxytocin release. This downregulation may cause the oxytocin system to become more excitable at term, resulting in the capacity for greater release of oxytocin during parturition.
PMID: 10964978
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