char = P;code = 80
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char = r;code = 114
char = a;code = 97
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char = h;code = 104
char = y;code = 121
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char = o;code = 111
char = i;code = 105
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char = m;code = 109
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char = n;code = 110
char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = ;code = 32
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char = o;code = 111
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char = n;code = 110
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char = a;code = 97
char = r;code = 114
char = a;code = 97
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = v;code = 118
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char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = D;code = 68
char = ;code = 32
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char = e;code = 101
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char = i;code = 105
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char = f;code = 102
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char = g;code = 103
char = n;code = 110
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = .;code = 46
result sql = Parathyroid hormone-related protein, parathyroid hormone, and vitamin D in hypercalcemia of malignancy.
Parathyroid hormone-related protein, parathyroid hormone, and vitamin D in hypercalcemia of malignancy.
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = r;code = 114
char = -;code = 45
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char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = h;code = 104
char = y;code = 121
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char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = a;code = 97
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char = i;code = 105
char = s;code = 115
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char = n;code = 110
char = o;code = 111
char = t;code = 116
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char = c;code = 99
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
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char = I;code = 73
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char = t;code = 116
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char = e;code = 101
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char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
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char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = c;code = 99
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char = i;code = 105
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char = n;code = 110
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char = s;code = 115
char = ,;code = 44
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char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = a;code = 97
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char = a;code = 97
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char = p;code = 112
char = e;code = 101
char = a;code = 97
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char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = s;code = 115
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = f;code = 102
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char = e;code = 101
char = ;code = 32
char = t;code = 116
char = u;code = 117
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char = o;code = 111
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char = ;code = 32
char = p;code = 112
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char = a;code = 97
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char = y;code = 121
char = r;code = 114
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char = d;code = 100
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char = h;code = 104
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = (;code = 40
char = P;code = 80
char = T;code = 84
char = H;code = 72
char = );code = 41
char = -;code = 45
char = r;code = 114
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char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = p;code = 112
char = r;code = 114
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char = e;code = 101
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char = n;code = 110
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = T;code = 84
char = H;code = 72
char = r;code = 114
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char = );code = 41
char = .;code = 46
char = ;code = 32
char = H;code = 72
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char = e;code = 101
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char = s;code = 115
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char = h;code = 104
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char = l;code = 108
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char = c;code = 99
char = a;code = 97
char = l;code = 108
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char = i;code = 105
char = a;code = 97
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char = o;code = 111
char = f;code = 102
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char = m;code = 109
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char = l;code = 108
char = i;code = 105
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char = c;code = 99
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char = t;code = 116
char = o;code = 111
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char = h;code = 104
char = o;code = 111
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char = t;code = 116
char = h;code = 104
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char = p;code = 112
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char = m;code = 109
char = a;code = 97
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char = y;code = 121
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char = y;code = 121
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char = e;code = 101
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char = p;code = 112
char = a;code = 97
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = o;code = 111
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char = d;code = 100
char = i;code = 105
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char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = h;code = 104
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char = v;code = 118
char = e;code = 101
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char = l;code = 108
char = o;code = 111
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char = ;code = 32
char = c;code = 99
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char = 1;code = 49
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char = s;code = 115
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char = h;code = 104
char = o;code = 111
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char = c;code = 99
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char = a;code = 97
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char = n;code = 110
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char = i;code = 105
char = c;code = 99
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char = ;code = 32
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char = ;code = 32
char = t;code = 116
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char = ;code = 32
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = 3;code = 51
char = ;code = 32
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char = ;code = 32
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
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char = o;code = 111
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char = n;code = 110
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char = d;code = 100
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char = ;code = 32
char = a;code = 97
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char = u;code = 117
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char = p;code = 112
char = o;code = 111
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char = r;code = 114
char = P;code = 80
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
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char = c;code = 99
char = t;code = 116
char = o;code = 111
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char = ;code = 32
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = n;code = 110
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char = l;code = 108
char = e;code = 101
char = ;code = 32
char = f;code = 102
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char = r;code = 114
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = r;code = 114
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char = l;code = 108
char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
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result sql = The pathogenesis of cancer-associated hypercalcemia is not yet completely understood. In the majority of cancer patients, hypercalcemia appears to be a consequence of the tumor production of parathyroid hormone (PTH)-related protein (PTHrP). However, patients with humoral hypercalcemia of malignancy, in contrast to those with primary hyperparathyroidism, have an uncoupled bone turnover, and they usually have low circulating levels of 1.25(OH)2D3. We performed a case-control study to assess the relationship of plasma PTHrP, PTH and 1.25(OH)2D3 with hypercalcemia in cancer patients with a variety of tumors. Sixty of these patients had hypercalcemia, and 45 were normocalcemic. We measured PTHrP and PTH by immunoradiometric assay (Nichols), and 1.25(OH)2D3 by radioreceptor assay (Nichols), in plasma in both groups of cancer patients. Using a logistic regression analysis, we found that the higher PTHrP in plasma, the higher association with hypercalcemia occurred in these patients. In addition, the decreased plasma levels of PTH and 1.25(OH)2D3 in the majority of cancer patients were found to be significantly associated with hypercalcemia. Our results indicate that the combined determination of PTH, PTHrP and 1.25(OH)2D3 in plasma represents a more comprehensive approach to the investigation of hypercalcemia in cancer patients. Our data also support the role of PTHrP as a humoral factor responsible for hypercalcemia in these patients.

Publication: Clin. Chim. Acta 2000 Jan 5 ;290(2)::189-97.
Publication Date: 2000 Jan 5
Study Author(s): Motellón, J L;Javort Jiménez, F;de Miguel, F;Jaras, M J;Díaz, A;Hurtado, J;Esbrit, P;
Institution: Department of Nephrology, Hospital de la Princesa, Madrid, Spain.
Shortcut link to this study:
The pathogenesis of cancer-associated hypercalcemia is not yet completely understood. In the majority of cancer patients, hypercalcemia appears to be a consequence of the tumor production of parathyroid hormone (PTH)-related protein (PTHrP). However, patients with humoral hypercalcemia of malignancy, in contrast to those with primary hyperparathyroidism, have an uncoupled bone turnover, and they usually have low circulating levels of 1.25(OH)2D3. We performed a case-control study to assess the relationship of plasma PTHrP, PTH and 1.25(OH)2D3 with hypercalcemia in cancer patients with a variety of tumors. Sixty of these patients had hypercalcemia, and 45 were normocalcemic. We measured PTHrP and PTH by immunoradiometric assay (Nichols), and 1.25(OH)2D3 by radioreceptor assay (Nichols), in plasma in both groups of cancer patients. Using a logistic regression analysis, we found that the higher PTHrP in plasma, the higher association with hypercalcemia occurred in these patients. In addition, the decreased plasma levels of PTH and 1.25(OH)2D3 in the majority of cancer patients were found to be significantly associated with hypercalcemia. Our results indicate that the combined determination of PTH, PTHrP and 1.25(OH)2D3 in plasma represents a more comprehensive approach to the investigation of hypercalcemia in cancer patients. Our data also support the role of PTHrP as a humoral factor responsible for hypercalcemia in these patients.
PMID: 10660809

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