|
|
char = C;code = 67
char = a;code = 97
char = p;code = 112
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char = i;code = 105
char = c;code = 99
char = i;code = 105
char = n;code = 110
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char = v;code = 118
char = e;code = 101
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char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
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char = s;code = 115
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char = r;code = 114
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result sql = Capsaicin-sensitive mechanisms are involved in cortical spreading depression-associated cerebral blood flow changes in rats.
Capsaicin-sensitive mechanisms are involved in cortical spreading depression-associated cerebral blood flow changes in rats.char = W;code = 87
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char = y;code = 121
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char = b;code = 98
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char = B;code = 66
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char = C;code = 67
char = B;code = 66
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char = s;code = 115
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result sql = We tested the hypothesis that capsaicin-sensitive mechanisms play a role in the cortical spreading depression (CSD)-related changes in cortical blood flow (CBF). CBF was measured with laser Doppler flowmetry in anesthetized rats. The animals were treated with capsaicin before (48 h-2 weeks) or during the experiments. This agent is thought to stimulate small-diameter sensory nerve fibers selectively and to deplete stored peptides. In the vehicle-treated group (n=8), the peak value of the CSD-associated hyperperfusion was 257+/-12% above the baseline (mean+/-SEM, P<0.05). In the groups treated with 20 and 40 microg/kg or 20 mg/kg capsaicin, there were only small decreases in CBF. In the groups treated with 100 mg/kg capsaicin, the CSD-associated hyperemia was reduced at 48 h (158+/-7%, P<0.05). However, at 96 h a transient hyperresponsiveness (390+/-38%, P<0.05) was observed, which had disappeared by 2 weeks. These results indicate that the manipulation of sensory neuropeptide stores results in a biphasic effect on CSD-induced CBF responses.
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result sql = Capsaicin-sensitive mechanisms are involved in cortical spreading depression-associated cerebral blood flow changes in rats.
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result sql = We tested the hypothesis that capsaicin-sensitive mechanisms play a role in the cortical spreading depression (CSD)-related changes in cortical blood flow (CBF). CBF was measured with laser Doppler flowmetry in anesthetized rats. The animals were treated with capsaicin before (48 h-2 weeks) or during the experiments. This agent is thought to stimulate small-diameter sensory nerve fibers selectively and to deplete stored peptides. In the vehicle-treated group (n=8), the peak value of the CSD-associated hyperperfusion was 257+/-12% above the baseline (mean+/-SEM, P<0.05). In the groups treated with 20 and 40 microg/kg or 20 mg/kg capsaicin, there were only small decreases in CBF. In the groups treated with 100 mg/kg capsaicin, the CSD-associated hyperemia was reduced at 48 h (158+/-7%, P<0.05). However, at 96 h a transient hyperresponsiveness (390+/-38%, P<0.05) was observed, which had disappeared by 2 weeks. These results indicate that the manipulation of sensory neuropeptide stores results in a biphasic effect on CSD-induced CBF responses.
Publication: Neurosci. Lett. 2000 Sep 29 ;292(1)::17-20.
Publication Date: 2000 Sep 29
Study Author(s): Bari, F;Paprika, D;Jancsó, G;Domoki, F;
Institution: Department of Physiology, Faculty of Medicine, University of Szeged, H-6720, Dóm tér 10, Szeged, Hungary. [email protected]
Shortcut link to this study:
Publication Date: 2000 Sep 29
Study Author(s): Bari, F;Paprika, D;Jancsó, G;Domoki, F;
Institution: Department of Physiology, Faculty of Medicine, University of Szeged, H-6720, Dóm tér 10, Szeged, Hungary. [email protected]
Shortcut link to this study:
We tested the hypothesis that capsaicin-sensitive mechanisms play a role in the cortical spreading depression (CSD)-related changes in cortical blood flow (CBF). CBF was measured with laser Doppler flowmetry in anesthetized rats. The animals were treated with capsaicin before (48 h-2 weeks) or during the experiments. This agent is thought to stimulate small-diameter sensory nerve fibers selectively and to deplete stored peptides. In the vehicle-treated group (n=8), the peak value of the CSD-associated hyperperfusion was 257+/-12% above the baseline (mean+/-SEM, P<0.05). In the groups treated with 20 and 40 microg/kg or 20 mg/kg capsaicin, there were only small decreases in CBF. In the groups treated with 100 mg/kg capsaicin, the CSD-associated hyperemia was reduced at 48 h (158+/-7%, P<0.05). However, at 96 h a transient hyperresponsiveness (390+/-38%, P<0.05) was observed, which had disappeared by 2 weeks. These results indicate that the manipulation of sensory neuropeptide stores results in a biphasic effect on CSD-induced CBF responses.
PMID: 10996439
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