|
|
char = M;code = 77
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char = c;code = 99
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char = n;code = 110
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char = i;code = 105
char = c;code = 99
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char = c;code = 99
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char = n;code = 110
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char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = -;code = 45
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char = l;code = 108
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char = m;code = 109
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char = c;code = 99
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char = s;code = 115
char = a;code = 97
char = .;code = 46
result sql = Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa.
Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa.char = T;code = 84
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char = e;code = 101
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char = w;code = 119
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char = m;code = 109
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char = d;code = 100
char = e;code = 101
char = m;code = 109
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char = c;code = 99
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char = v;code = 118
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char = e;code = 101
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = n;code = 110
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char = a;code = 97
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char = f;code = 102
char = ;code = 32
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char = o;code = 111
char = l;code = 108
char = y;code = 121
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = k;code = 107
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = ,;code = 44
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char = m;code = 109
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char = n;code = 110
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char = s;code = 115
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
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char = g;code = 103
char = h;code = 104
char = ;code = 32
char = w;code = 119
char = h;code = 104
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char = l;code = 108
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char = d;code = 100
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char = e;code = 101
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = o;code = 111
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char = d;code = 100
char = .;code = 46
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char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = g;code = 103
char = a;code = 97
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char = t;code = 116
char = r;code = 114
char = o;code = 111
char = i;code = 105
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char = e;code = 101
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char = i;code = 105
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = b;code = 98
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char = o;code = 111
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char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = c;code = 99
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char = l;code = 108
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char = W;code = 87
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char = h;code = 104
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result sql = There is now ample epidemiological evidence to show that the wide international variations in the incidence of both adenomatous polyps and colo-rectal cancer are linked to diet, but the mechanisms through which particular dietary constituents influence the onset of neoplasia are poorly understood. The crypt epithelial cells of the human gastrointestinal mucosa are amongst the most rapidly proliferating tissues in the body, and those of the colorectum are particularly vulnerable to neoplasia. Within the crypt, continuous division of basally localized stem cells gives rise to daughter cells that may divide once or twice again, before differentiating and migrating to the mucosal surface. The majority of nascent crypt epithelial cells differentiate, become senescent and are shed into the gut lumen, but a small proportion die by apoptosis soon after cell division. Various lines of evidence suggest that these pathways of programmed cell death provide a protective mechanism against induction of neoplasia by removing genetically damaged stem cells before they can divide further and give rise to precancerous lesions. There is evidence that the short-chain fatty acid butyrate and several different classes of food constituents, including some polyunsaturated fatty acids, flavonoids and glucosinolate breakdown products, can regulate the processes of cell proliferation and death in vitro, and in colorectal crypts in vivo. All three classes of food components suppress the emergence of aberrant crypt foci in animal models of carcinogenesis. The cellular mechanisms underlying these phenomena, and their possible significance for human health, are discussed.
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result sql = Mechanisms and anticarcinogenic effects of diet-related apoptosis in the intestinal mucosa.
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char = d;code = 100
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char = g;code = 103
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char = a;code = 97
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char = ;code = 32
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char = e;code = 101
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char = r;code = 114
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char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = l;code = 108
char = l;code = 108
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char = e;code = 101
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char = i;code = 105
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char = d;code = 100
char = ;code = 32
char = d;code = 100
char = e;code = 101
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char = h;code = 104
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = l;code = 108
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char = t;code = 116
char = a;code = 97
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char = ;code = 32
char = c;code = 99
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char = y;code = 121
char = p;code = 112
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char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
char = .;code = 46
char = ;code = 32
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = ;code = 32
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char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = t;code = 116
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char = s;code = 115
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char = p;code = 112
char = p;code = 112
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char = ;code = 32
char = e;code = 101
char = m;code = 109
char = e;code = 101
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char = ;code = 32
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char = l;code = 108
char = y;code = 121
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char = n;code = 110
char = g;code = 103
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char = o;code = 111
char = m;code = 109
char = e;code = 101
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char = a;code = 97
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = i;code = 105
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = ;code = 32
char = f;code = 102
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char = r;code = 114
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
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char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = s;code = 115
char = s;code = 115
char = e;code = 101
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result sql = There is now ample epidemiological evidence to show that the wide international variations in the incidence of both adenomatous polyps and colo-rectal cancer are linked to diet, but the mechanisms through which particular dietary constituents influence the onset of neoplasia are poorly understood. The crypt epithelial cells of the human gastrointestinal mucosa are amongst the most rapidly proliferating tissues in the body, and those of the colorectum are particularly vulnerable to neoplasia. Within the crypt, continuous division of basally localized stem cells gives rise to daughter cells that may divide once or twice again, before differentiating and migrating to the mucosal surface. The majority of nascent crypt epithelial cells differentiate, become senescent and are shed into the gut lumen, but a small proportion die by apoptosis soon after cell division. Various lines of evidence suggest that these pathways of programmed cell death provide a protective mechanism against induction of neoplasia by removing genetically damaged stem cells before they can divide further and give rise to precancerous lesions. There is evidence that the short-chain fatty acid butyrate and several different classes of food constituents, including some polyunsaturated fatty acids, flavonoids and glucosinolate breakdown products, can regulate the processes of cell proliferation and death in vitro, and in colorectal crypts in vivo. All three classes of food components suppress the emergence of aberrant crypt foci in animal models of carcinogenesis. The cellular mechanisms underlying these phenomena, and their possible significance for human health, are discussed.
Publication: Nutr Res Rev 2001 Dec ;14(2)::229-56. :doi: 10.1079/NRR200128.
Publication Date: 2001 Dec
Study Author(s): Johnson, I T;
Institution: Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK.
Shortcut link to this study:
Publication Date: 2001 Dec
Study Author(s): Johnson, I T;
Institution: Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK.
Shortcut link to this study:
There is now ample epidemiological evidence to show that the wide international variations in the incidence of both adenomatous polyps and colo-rectal cancer are linked to diet, but the mechanisms through which particular dietary constituents influence the onset of neoplasia are poorly understood. The crypt epithelial cells of the human gastrointestinal mucosa are amongst the most rapidly proliferating tissues in the body, and those of the colorectum are particularly vulnerable to neoplasia. Within the crypt, continuous division of basally localized stem cells gives rise to daughter cells that may divide once or twice again, before differentiating and migrating to the mucosal surface. The majority of nascent crypt epithelial cells differentiate, become senescent and are shed into the gut lumen, but a small proportion die by apoptosis soon after cell division. Various lines of evidence suggest that these pathways of programmed cell death provide a protective mechanism against induction of neoplasia by removing genetically damaged stem cells before they can divide further and give rise to precancerous lesions. There is evidence that the short-chain fatty acid butyrate and several different classes of food constituents, including some polyunsaturated fatty acids, flavonoids and glucosinolate breakdown products, can regulate the processes of cell proliferation and death in vitro, and in colorectal crypts in vivo. All three classes of food components suppress the emergence of aberrant crypt foci in animal models of carcinogenesis. The cellular mechanisms underlying these phenomena, and their possible significance for human health, are discussed.
PMID: 19087425
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