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result sql = The effects of lamotrigine on sleep in patients with epilepsy.
The effects of lamotrigine on sleep in patients with epilepsy.
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char = r;code = 114
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char = ;code = 32
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char = G;code = 71
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char = a;code = 97
char = t;code = 116
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char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = a;code = 97
char = l;code = 108
char = s;code = 115
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char = a;code = 97
char = n;code = 110
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char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = i;code = 105
char = f;code = 102
char = t;code = 116
char = s;code = 115
char = ;code = 32
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char = d;code = 100
char = ;code = 32
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char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = R;code = 82
char = E;code = 69
char = M;code = 77
char = ;code = 32
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char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = d;code = 100
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = o;code = 111
char = ;code = 32
char = s;code = 115
char = u;code = 117
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char = j;code = 106
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char = c;code = 99
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char = ;code = 32
char = r;code = 114
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char = o;code = 111
char = r;code = 114
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char = e;code = 101
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char = i;code = 105
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char = o;code = 111
char = m;code = 109
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char = w;code = 119
char = i;code = 105
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char = s;code = 115
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char = u;code = 117
char = p;code = 112
char = t;code = 116
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char = e;code = 101
char = ;code = 32
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char = o;code = 111
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char = l;code = 108
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char = e;code = 101
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char = n;code = 110
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = e;code = 101
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result sql = PURPOSE : The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in REM, slow-wave sleep (SWS) and sleep latency, and increased percentage of light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of lamotrigine (LTG) on sleep.

METHODS : Ten adults with focal epilepsy, in whom the decision was made to add LTG to either phenytoin (PHT) or carbamazepine (CBZ) for control of seizures, were the subjects of this study. Patients underwent pre- and posttreatment polysomnography (PSG) and completed sleep questionnaires. Polygraphic variables and Epworth Sleepiness Scale (ESS) scores, a subjective measure of sleep propensity, were compared by using the Wilcoxon sign rank test.

RESULTS : Seven patients were taking CBZ, and three were treated with PHT. All subjects were titrated to an LTG dose of 400 mg/day. Treatment with LTG produced a significant decrease in SWS and an increase in stage 2 sleep percentage. No significant difference in ESS or any of the other polygraphic variables was observed. However, LTG treatment was associated with a reduction in arousals and stage shifts and an increase in REM periods. No subjects reported insomnia with treatment.

CONCLUSIONS : LTG appears to be less disruptive to sleep than some of the older AEDs.

Publication: Epilepsia 2001 Dec ;42(12)::1569-73.
Publication Date: 2001 Dec
Study Author(s): Foldvary, N;Perry, M;Lee, J;Dinner, D;Morris, H H;
Institution: Department of Neurology and Epidemiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. foldvan.ccf.org
Shortcut link to this study:
PURPOSE : The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in REM, slow-wave sleep (SWS) and sleep latency, and increased percentage of light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of lamotrigine (LTG) on sleep.

METHODS : Ten adults with focal epilepsy, in whom the decision was made to add LTG to either phenytoin (PHT) or carbamazepine (CBZ) for control of seizures, were the subjects of this study. Patients underwent pre- and posttreatment polysomnography (PSG) and completed sleep questionnaires. Polygraphic variables and Epworth Sleepiness Scale (ESS) scores, a subjective measure of sleep propensity, were compared by using the Wilcoxon sign rank test.

RESULTS : Seven patients were taking CBZ, and three were treated with PHT. All subjects were titrated to an LTG dose of 400 mg/day. Treatment with LTG produced a significant decrease in SWS and an increase in stage 2 sleep percentage. No significant difference in ESS or any of the other polygraphic variables was observed. However, LTG treatment was associated with a reduction in arousals and stage shifts and an increase in REM periods. No subjects reported insomnia with treatment.

CONCLUSIONS : LTG appears to be less disruptive to sleep than some of the older AEDs.
PMID: 11879368

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