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char = o;code = 111
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char = n;code = 110
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char = d;code = 100
char = i;code = 105
char = a;code = 97
char = b;code = 98
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = t;code = 116
char = s;code = 115
char = :;code = 58
char = ;code = 32
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = c;code = 99
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char = t;code = 116
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = .;code = 46
result sql = Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine.
Autonomic neuropathy in streptozotocin diabetic rats: effect of acetyl-L-carnitine.
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char = s;code = 115
char = t;code = 116
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char = ;code = 32
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char = e;code = 101
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char = g;code = 103
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char = a;code = 97
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char = l;code = 108
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
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char = ;code = 32
char = r;code = 114
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char = i;code = 105
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char = H;code = 72
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char = m;code = 109
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char = ;code = 32
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = m;code = 109
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char = b;code = 98
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char = i;code = 105
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char = s;code = 115
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char = 3;code = 51
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char = .;code = 46
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char = 1;code = 49
char = 1;code = 49
char = +;code = 43
char = /;code = 47
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char = 3;code = 51
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char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = m;code = 109
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char = ;code = 32
char = P;code = 80
char = <;code = 60
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char = .;code = 46
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char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = C;code = 67
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char = 6;code = 54
char = 9;code = 57
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char = /;code = 47
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char = b;code = 98
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = ;code = 32
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result sql = The present study was designed to characterize cardiac autonomic neuropathy in streptozotocin-induced (45 mg/kg i.v.) diabetic rat by analysis of heart rate variability (HRV), and to assess, in this model, the effects of treatment with acetyl-L-carnitine (ALC). Heart rate was reduced in diabetic rats (332+/-22 vs. 411+/-35 beat per min; P<0.0001). This bradycardia was partly reversed with ALC (369+/-52 beat per min; P<0.05 vs. untreated). Both time- and frequency-domain parameters of HRV were significantly reduced in diabetic rats. The reduction of spectral power was around 50% at high frequencies and about 70% at low frequencies, suggesting a decrease of parasympathetic activity. Low/high frequency ratio was significantly decreased in diabetic rats suggesting decreased sympathetic tone, while nonlinear analysis indicated a reduction of the chaotic complexity of heart rate dynamics in diabetic rats. Standard deviation of heart rate in ALC-treated rats was significantly higher than in untreated diabetic rats (P<0.0001). ALC counteracts the reduction of the power spectrum observed in diabetic animals (P<0.0005) normalizing the spectra profile. ALC restored chaotic complexity of heart rate dynamics. These results on the whole indicate that both sympathetic and parasympathetic cardiac tone were reduced significantly in diabetic rats and that ALC treatment prevents the development of autonomic neuropathy in streptozotocin-induced diabetes in rats.

Publication: Diabetes Res. Clin. Pract. 2002 Jun ;56(3)::173-80.
Publication Date: 2002 Jun
Study Author(s): Lo Giudice, Pietro;Careddu, Antonia;Magni, Giuseppina;Quagliata, Teresa;Pacifici, Licia;Carminati, Paolo;
Institution: Department of Pharmacology, Research and Development, Sigma Tau, Pomezia 00040, Italy. [email protected]
Shortcut link to this study:
The present study was designed to characterize cardiac autonomic neuropathy in streptozotocin-induced (45 mg/kg i.v.) diabetic rat by analysis of heart rate variability (HRV), and to assess, in this model, the effects of treatment with acetyl-L-carnitine (ALC). Heart rate was reduced in diabetic rats (332+/-22 vs. 411+/-35 beat per min; P<0.0001). This bradycardia was partly reversed with ALC (369+/-52 beat per min; P<0.05 vs. untreated). Both time- and frequency-domain parameters of HRV were significantly reduced in diabetic rats. The reduction of spectral power was around 50% at high frequencies and about 70% at low frequencies, suggesting a decrease of parasympathetic activity. Low/high frequency ratio was significantly decreased in diabetic rats suggesting decreased sympathetic tone, while nonlinear analysis indicated a reduction of the chaotic complexity of heart rate dynamics in diabetic rats. Standard deviation of heart rate in ALC-treated rats was significantly higher than in untreated diabetic rats (P<0.0001). ALC counteracts the reduction of the power spectrum observed in diabetic animals (P<0.0005) normalizing the spectra profile. ALC restored chaotic complexity of heart rate dynamics. These results on the whole indicate that both sympathetic and parasympathetic cardiac tone were reduced significantly in diabetic rats and that ALC treatment prevents the development of autonomic neuropathy in streptozotocin-induced diabetes in rats.
PMID: 11947964

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