|
|
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char = d;code = 100
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result sql = Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells.
Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells.char = T;code = 84
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char = d;code = 100
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char = (;code = 40
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char = i;code = 105
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
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char = D;code = 68
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char = 5;code = 53
char = .;code = 46
char = ;code = 32
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char = Y;code = 89
char = P;code = 80
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char = 4;code = 52
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = s;code = 115
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char = ;code = 32
char = r;code = 114
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char = p;code = 112
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char = f;code = 102
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char = d;code = 100
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char = i;code = 105
char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = l;code = 108
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char = t;code = 116
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char = 1;code = 49
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char = D;code = 68
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char = k;code = 107
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char = n;code = 110
char = ;code = 32
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char = o;code = 111
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char = ;code = 32
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char = t;code = 116
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
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char = o;code = 111
char = d;code = 100
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = o;code = 111
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char = e;code = 101
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char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = c;code = 99
char = e;code = 101
char = l;code = 108
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = i;code = 105
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char = e;code = 101
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char = s;code = 115
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char = f;code = 102
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char = C;code = 67
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char = i;code = 105
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char = o;code = 111
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char = h;code = 104
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = e;code = 101
char = a;code = 97
char = n;code = 110
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char = <;code = 60
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = The high ingestion of soybean products in Asian countries has been suggested to be responsible for a reduced incidence of prostate cancer. The mechanism of action, however, is unknown. Our data demonstrate that genistein and some isoflavone metabolites reduce the activity of 25-D3-24-hydroxylase (CYP24) in the human prostate cancer-derived cell line DU-145. CYP24 is also responsible for degradation of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 which is known to be antimitotic and prodifferentiating in prostate cancer cells. High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite. This could be prevented by ingestion of genistein-containing food such as soybeans.
char = s;code = 115
char = o;code = 111
char = f;code = 102
char = l;code = 108
char = a;code = 97
char = v;code = 118
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = c;code = 99
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells.
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char = s;code = 115
char = u;code = 117
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = y;code = 121
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char = e;code = 101
char = a;code = 97
char = n;code = 110
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result sql = The high ingestion of soybean products in Asian countries has been suggested to be responsible for a reduced incidence of prostate cancer. The mechanism of action, however, is unknown. Our data demonstrate that genistein and some isoflavone metabolites reduce the activity of 25-D3-24-hydroxylase (CYP24) in the human prostate cancer-derived cell line DU-145. CYP24 is also responsible for degradation of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 which is known to be antimitotic and prodifferentiating in prostate cancer cells. High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite. This could be prevented by ingestion of genistein-containing food such as soybeans.
Publication: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002 Sep 25 ;777(1-2)::261-8.
Publication Date: 2002 Sep 25
Study Author(s): Farhan, Hesso;Wähälä, Kristiina;Adlercreutz, Herman;Cross, Heide S;
Institution: Institute of Pathophysiology, University of Vienna Medical School, AKH, Währingergürtel 18-20 A-1090, Vienna, Austria.
Shortcut link to this study:
Publication Date: 2002 Sep 25
Study Author(s): Farhan, Hesso;Wähälä, Kristiina;Adlercreutz, Herman;Cross, Heide S;
Institution: Institute of Pathophysiology, University of Vienna Medical School, AKH, Währingergürtel 18-20 A-1090, Vienna, Austria.
Shortcut link to this study:
The high ingestion of soybean products in Asian countries has been suggested to be responsible for a reduced incidence of prostate cancer. The mechanism of action, however, is unknown. Our data demonstrate that genistein and some isoflavone metabolites reduce the activity of 25-D3-24-hydroxylase (CYP24) in the human prostate cancer-derived cell line DU-145. CYP24 is also responsible for degradation of the active vitamin D metabolite 1,25-dihydroxyvitamin D3 which is known to be antimitotic and prodifferentiating in prostate cancer cells. High levels of CYP24 frequently found in prostate cancer cells may thus degrade the active metabolite. This could be prevented by ingestion of genistein-containing food such as soybeans.
PMID: 12270218
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