char = Z;code = 90
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char = c;code = 99
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char = i;code = 105
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char = i;code = 105
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char = r;code = 114
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char = k;code = 107
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char = p;code = 112
char = p;code = 112
char = a;code = 97
char = ;code = 32
char = B;code = 66
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = n;code = 110
char = d;code = 100
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char = t;code = 116
char = i;code = 105
char = z;code = 122
char = e;code = 101
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char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = a;code = 97
char = t;code = 116
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char = r;code = 114
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char = e;code = 101
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char = l;code = 108
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char = t;code = 116
char = o;code = 111
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char = c;code = 99
char = y;code = 121
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char = t;code = 116
char = o;code = 111
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char = a;code = 97
char = g;code = 103
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char = t;code = 116
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char = .;code = 46
result sql = Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
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char = c;code = 99
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char = c;code = 99
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char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = s;code = 115
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char = i;code = 105
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char = n;code = 110
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char = o;code = 111
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char = z;code = 122
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char = c;code = 99
char = c;code = 99
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char = u;code = 117
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char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = m;code = 109
char = a;code = 97
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char = g;code = 103
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char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = c;code = 99
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char = l;code = 108
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char = ,;code = 44
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char = i;code = 105
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char = ;code = 32
char = n;code = 110
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char = t;code = 116
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = c;code = 99
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char = m;code = 109
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
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char = w;code = 119
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char = ;code = 32
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char = e;code = 101
char = m;code = 109
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char = s;code = 115
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char = r;code = 114
char = a;code = 97
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char = e;code = 101
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char = b;code = 98
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char = ;code = 32
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char = m;code = 109
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char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = (;code = 40
char = N;code = 78
char = F;code = 70
char = );code = 41
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char = k;code = 107
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char = p;code = 112
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char = r;code = 114
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char = i;code = 105
char = n;code = 110
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char = P;code = 80
char = C;code = 67
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char = U;code = 85
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char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
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char = r;code = 114
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char = l;code = 108
char = l;code = 108
char = e;code = 101
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char = a;code = 97
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char = i;code = 105
char = a;code = 97
char = p;code = 112
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char = J;code = 74
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result sql = Prostate carcinogenesis involves transformation of zinc-accumulating normal epithelial cells to malignant cells, which do not accumulate zinc. In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells, reduce expression of NF-kappa B-controlled antiapoptotic protein c-IAP2, and activate c-Jun NH(2)-terminal kinases. Preincubation of PC-3 cells with physiological concentrations of zinc sensitized tumor cells to tumor necrosis factor (TNF)-alpha, and paclitaxel mediated cell death as defined by terminal deoxynucleotidyl transferase-mediated nick end labeling assay. These results suggest one possible mechanism for the inhibitory effect of zinc on the development and progression of prostate malignancy and might have important consequences for the prevention and treatment of prostate cancer.

Publication: Clin. Cancer Res. 2002 Nov ;8(11)::3579-83.
Publication Date: 2002 Nov
Study Author(s): Uzzo, Robert G;Leavis, Paul;Hatch, William;Gabai, Vladimir L;Dulin, Nickolai;Zvartau, Nadezhda;Kolenko, Vladimir M;
Institution: Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Shortcut link to this study:
Prostate carcinogenesis involves transformation of zinc-accumulating normal epithelial cells to malignant cells, which do not accumulate zinc. In this study, we demonstrate by immunoblotting and immunohistochemistry that physiological levels of zinc inhibit activation of nuclear factor (NF)-kappa B transcription factor in PC-3 and DU-145 human prostate cancer cells, reduce expression of NF-kappa B-controlled antiapoptotic protein c-IAP2, and activate c-Jun NH(2)-terminal kinases. Preincubation of PC-3 cells with physiological concentrations of zinc sensitized tumor cells to tumor necrosis factor (TNF)-alpha, and paclitaxel mediated cell death as defined by terminal deoxynucleotidyl transferase-mediated nick end labeling assay. These results suggest one possible mechanism for the inhibitory effect of zinc on the development and progression of prostate malignancy and might have important consequences for the prevention and treatment of prostate cancer.
PMID: 12429649

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