|
|
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char = R;code = 82
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char = C;code = 67
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char = d;code = 100
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char = l;code = 108
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char = v;code = 118
char = i;code = 105
char = a;code = 97
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char = R;code = 82
char = 3;code = 51
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = E;code = 69
char = R;code = 82
char = 6;code = 54
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char = t;code = 116
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char = m;code = 109
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char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.
Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.char = T;code = 84
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = V;code = 86
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char = R;code = 82
char = );code = 41
char = ;code = 32
char = m;code = 109
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char = d;code = 100
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char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = s;code = 115
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char = o;code = 111
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char = ;code = 32
char = 1;code = 49
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char = 2;code = 50
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char = m;code = 109
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char = ;code = 32
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char = 5;code = 53
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char = );code = 41
char = ;code = 32
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char = a;code = 97
char = l;code = 108
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = n;code = 110
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char = e;code = 101
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char = i;code = 105
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char = a;code = 97
char = l;code = 108
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char = g;code = 103
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char = c;code = 99
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char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
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char = u;code = 117
char = m;code = 109
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char = a;code = 97
char = b;code = 98
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char = o;code = 111
char = r;code = 114
char = p;code = 112
char = t;code = 116
char = i;code = 105
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char = e;code = 101
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char = 5;code = 53
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char = a;code = 97
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char = o;code = 111
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char = x;code = 120
char = e;code = 101
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = i;code = 105
char = -;code = 45
char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = e;code = 101
char = f;code = 102
char = f;code = 102
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char = c;code = 99
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char = s;code = 115
char = ,;code = 44
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char = w;code = 119
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char = e;code = 101
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char = m;code = 109
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char = n;code = 110
char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = h;code = 104
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char = e;code = 101
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char = f;code = 102
char = i;code = 105
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char = o;code = 111
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
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char = o;code = 111
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char = m;code = 109
char = e;code = 101
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char = P;code = 80
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char = 5;code = 53
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char = (;code = 40
char = C;code = 67
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char = P;code = 80
char = );code = 41
char = ;code = 32
char = e;code = 101
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char = z;code = 122
char = y;code = 121
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char = m;code = 109
char = a;code = 97
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char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = e;code = 101
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char = o;code = 111
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = i;code = 105
char = n;code = 110
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char = m;code = 109
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = T;code = 84
char = -;code = 45
char = 2;code = 50
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char = );code = 41
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = 1;code = 49
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char = (;code = 40
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char = 8;code = 56
char = );code = 41
char = M;code = 77
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char = 1;code = 49
char = ,;code = 44
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char = 5;code = 53
char = D;code = 68
char = (;code = 40
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = r;code = 114
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char = s;code = 115
char = u;code = 117
char = l;code = 108
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char = d;code = 100
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char = i;code = 105
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char = >;code = 62
char = /;code = 47
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char = i;code = 105
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char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = 3;code = 51
char = A;code = 65
char = 4;code = 52
char = ;code = 32
char = m;code = 109
char = R;code = 82
char = N;code = 78
char = A;code = 65
char = ;code = 32
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char = e;code = 101
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char = n;code = 110
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = R;code = 82
char = T;code = 84
char = -;code = 45
char = P;code = 80
char = C;code = 67
char = R;code = 82
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char = a;code = 97
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char = d;code = 100
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char = W;code = 87
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char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = ;code = 32
char = b;code = 98
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char = t;code = 116
char = i;code = 105
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char = S;code = 83
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char = x;code = 120
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char = v;code = 118
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char = t;code = 116
char = a;code = 97
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char = n;code = 110
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char = R;code = 82
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char = l;code = 108
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char = k;code = 107
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char = g;code = 103
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char = g;code = 103
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char = G;code = 71
char = G;code = 71
char = T;code = 84
char = C;code = 67
char = A;code = 65
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char = 1;code = 49
char = 5;code = 53
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = u;code = 117
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char = c;code = 99
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char = o;code = 111
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char = R;code = 82
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = ;code = 32
char = g;code = 103
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char = e;code = 101
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char = ;code = 32
char = T;code = 84
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char = g;code = 103
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char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = 3;code = 51
char = A;code = 65
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char = a;code = 97
char = y;code = 121
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char = v;code = 118
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char = e;code = 101
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char = h;code = 104
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char = s;code = 115
char = m;code = 109
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char = f;code = 102
char = o;code = 111
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char = d;code = 100
char = e;code = 101
char = t;code = 116
char = o;code = 111
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char = f;code = 102
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char = c;code = 99
char = a;code = 97
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char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = e;code = 101
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char = c;code = 99
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char = ;code = 32
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char = r;code = 114
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char = o;code = 111
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char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = The nuclear vitamin D receptor (VDR) mediates the effects of 1,25-dihydroxyvitamin D(3) (1,25D(3)) to alter intestinal gene transcription and promote calcium absorption. Because 1,25D(3) also exerts anti-cancer effects, we examined the efficacy of 1,25D(3) to induce cytochrome P450 (CYP) enzymes. Exposure of human colorectal adenocarcinoma cells (HT-29) to 10(-8)M 1,25D(3) resulted in >/=3-fold induction of CYP3A4 mRNA and protein as assessed by RT-PCR and Western blotting, respectively. Six vitamin D responsive element (VDRE)-like sequences in the promoter region of the CYP3A4 gene were then individually tested for their ability to enhance transcription. A canonical DR3-type element in the distal region of the promoter (-7719-GGGTCAgcaAGTTCA-7733), and a proximal, non-classical everted repeat with a spacer of 6 bp (ER6; -169-TGAACTcaaaggAGGTCA-152) were identified as functional VDREs in this CYP gene. These data suggest that 1,25D(3)-dependent, VDR-mediated induction of CYP3A4 may constitute a chemoprotective mechanism for detoxification of enteric xenobiotics and carcinogens.
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = V;code = 86
char = D;code = 68
char = R;code = 82
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = 3;code = 51
char = A;code = 65
char = 4;code = 52
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = ;code = 32
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = D;code = 68
char = R;code = 82
char = 3;code = 51
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = E;code = 69
char = R;code = 82
char = 6;code = 54
char = ;code = 32
char = v;code = 118
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char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = D;code = 68
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.
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result sql = The nuclear vitamin D receptor (VDR) mediates the effects of 1,25-dihydroxyvitamin D(3) (1,25D(3)) to alter intestinal gene transcription and promote calcium absorption. Because 1,25D(3) also exerts anti-cancer effects, we examined the efficacy of 1,25D(3) to induce cytochrome P450 (CYP) enzymes. Exposure of human colorectal adenocarcinoma cells (HT-29) to 10(-8)M 1,25D(3) resulted in >/=3-fold induction of CYP3A4 mRNA and protein as assessed by RT-PCR and Western blotting, respectively. Six vitamin D responsive element (VDRE)-like sequences in the promoter region of the CYP3A4 gene were then individually tested for their ability to enhance transcription. A canonical DR3-type element in the distal region of the promoter (-7719-GGGTCAgcaAGTTCA-7733), and a proximal, non-classical everted repeat with a spacer of 6 bp (ER6; -169-TGAACTcaaaggAGGTCA-152) were identified as functional VDREs in this CYP gene. These data suggest that 1,25D(3)-dependent, VDR-mediated induction of CYP3A4 may constitute a chemoprotective mechanism for detoxification of enteric xenobiotics and carcinogens.
Publication: Biochem. Biophys. Res. Commun. 2002 Dec 20 ;299(5)::730-8.
Publication Date: 2002 Dec 20
Study Author(s): Thompson, Paul D;Jurutka, Peter W;Whitfield, G Kerr;Myskowski, Sandy M;Eichhorst, Kristina R;Dominguez, Carlos Encinas;Haussler, Carol A;Haussler, Mark R;
Institution: Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Shortcut link to this study:
Publication Date: 2002 Dec 20
Study Author(s): Thompson, Paul D;Jurutka, Peter W;Whitfield, G Kerr;Myskowski, Sandy M;Eichhorst, Kristina R;Dominguez, Carlos Encinas;Haussler, Carol A;Haussler, Mark R;
Institution: Department of Biochemistry and Molecular Biophysics, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Shortcut link to this study:
The nuclear vitamin D receptor (VDR) mediates the effects of 1,25-dihydroxyvitamin D(3) (1,25D(3)) to alter intestinal gene transcription and promote calcium absorption. Because 1,25D(3) also exerts anti-cancer effects, we examined the efficacy of 1,25D(3) to induce cytochrome P450 (CYP) enzymes. Exposure of human colorectal adenocarcinoma cells (HT-29) to 10(-8)M 1,25D(3) resulted in >/=3-fold induction of CYP3A4 mRNA and protein as assessed by RT-PCR and Western blotting, respectively. Six vitamin D responsive element (VDRE)-like sequences in the promoter region of the CYP3A4 gene were then individually tested for their ability to enhance transcription. A canonical DR3-type element in the distal region of the promoter (-7719-GGGTCAgcaAGTTCA-7733), and a proximal, non-classical everted repeat with a spacer of 6 bp (ER6; -169-TGAACTcaaaggAGGTCA-152) were identified as functional VDREs in this CYP gene. These data suggest that 1,25D(3)-dependent, VDR-mediated induction of CYP3A4 may constitute a chemoprotective mechanism for detoxification of enteric xenobiotics and carcinogens.
PMID: 12470639
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