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char = k;code = 107
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char = l;code = 108
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char = e;code = 101
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char = ;code = 32
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char = c;code = 99
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char = r;code = 114
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char = l;code = 108
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char = t;code = 116
char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
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char = h;code = 104
char = e;code = 101
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char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
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char = c;code = 99
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char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = .;code = 46
result sql = Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent.
Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent.
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = j;code = 106
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char = .;code = 46
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char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = H;code = 72
char = E;code = 69
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char = c;code = 99
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char = e;code = 101
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char = t;code = 116
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result sql = Genistein is a major component of soybean isoflavone and has preventive effect against breast cancer. In breast cancer, the over-expression of HER-2 contributes to malignant transformation of the cancer cells. The present study was undertaken to estimate if genistein could act as a useful anti-cancer agent against a breast cancer cell overexpressing HER-2 in combination with a conventional chemotherapy agent, adriamycin (ADR). Genistein enhanced cytotoxic effect of ADR at low doses less than IC50 against the human breast cancer cell. The enhancing effect was mainly dependent on the elevation of necrotic-like cell death but not apoptotic cell death. In conjugation with this event, remarkable inactivation of HER-2 and Akt in the breast cancer cell was caused by the combination of genistein and ADR. These results suggest that genistein enhances necrotic-like cell death of the breast cancer cells through the inactivation of HER-2 receptor and Akt in combination with ADR.

Publication: Res. Commun. Mol. Pathol. Pharmacol. 2003 ;113-114:149-58.
Publication Date: 2003
Study Author(s): Satoh, Haruna;Nishikawa, Kazuhiro;Suzuki, Kazuyuki;Asano, Ryuji;Virgona, Nantiga;Ichikawa, Tomio;Hagiwara, Kiyokazu;Yano, Tomohiro;
Institution: Department of Food Science Research for Health, National Institute of Health and Nutrition, Tokyo 162-8636, Japan.
Shortcut link to this study:
Genistein is a major component of soybean isoflavone and has preventive effect against breast cancer. In breast cancer, the over-expression of HER-2 contributes to malignant transformation of the cancer cells. The present study was undertaken to estimate if genistein could act as a useful anti-cancer agent against a breast cancer cell overexpressing HER-2 in combination with a conventional chemotherapy agent, adriamycin (ADR). Genistein enhanced cytotoxic effect of ADR at low doses less than IC50 against the human breast cancer cell. The enhancing effect was mainly dependent on the elevation of necrotic-like cell death but not apoptotic cell death. In conjugation with this event, remarkable inactivation of HER-2 and Akt in the breast cancer cell was caused by the combination of genistein and ADR. These results suggest that genistein enhances necrotic-like cell death of the breast cancer cells through the inactivation of HER-2 receptor and Akt in combination with ADR.
PMID: 15686114

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