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result sql = Vitamin D enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive oxygen species and mitochondria.
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char = l;code = 108
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = ;code = 32
char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = h;code = 104
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char = r;code = 114
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = i;code = 105
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char = u;code = 117
char = c;code = 99
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = N;code = 78
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = y;code = 121
char = s;code = 115
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char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = ;code = 32
char = r;code = 114
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char = d;code = 100
char = u;code = 117
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = g;code = 103
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char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
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char = e;code = 101
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char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = d;code = 100
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = c;code = 99
char = a;code = 97
char = s;code = 115
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = y;code = 121
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char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = R;code = 82
char = O;code = 79
char = S;code = 83
char = );code = 41
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = a;code = 97
char = ;code = 32
char = k;code = 107
char = e;code = 101
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = k;code = 107
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = n;code = 110
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char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = m;code = 109
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = n;code = 110
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char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = d;code = 100
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char = c;code = 99
char = a;code = 97
char = s;code = 115
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = e;code = 101
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char = d;code = 100
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char = t;code = 116
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char = a;code = 97
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char = h;code = 104
char = w;code = 119
char = a;code = 97
char = y;code = 121
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char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
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char = u;code = 117
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char = d;code = 100
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = e;code = 101
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = v;code = 118
char = e;code = 101
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char = p;code = 112
char = r;code = 114
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = R;code = 82
char = O;code = 79
char = S;code = 83
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = m;code = 109
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = e;code = 101
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char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = D;code = 68
char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = P;code = 80
char = s;code = 115
char = i;code = 105
char = );code = 41
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = -;code = 45
char = s;code = 115
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char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = c;code = 99
char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = J;code = 74
char = C;code = 67
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char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = o;code = 111
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char = e;code = 101
char = ;code = 32
char = a;code = 97
char = u;code = 117
char = g;code = 103
char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = d;code = 100
char = r;code = 114
char = o;code = 111
char = p;code = 112
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char = i;code = 105
char = n;code = 110
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char = D;code = 68
char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = P;code = 80
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
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char = e;code = 101
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char = e;code = 101
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char = f;code = 102
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char = c;code = 99
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char = r;code = 114
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char = b;code = 98
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char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = a;code = 97
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = P;code = 80
char = s;code = 115
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char = ;code = 32
char = w;code = 119
char = a;code = 97
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char = c;code = 99
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char = e;code = 101
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char = r;code = 114
char = o;code = 111
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char = h;code = 104
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char = a;code = 97
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char = o;code = 111
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = d;code = 100
char = r;code = 114
char = o;code = 111
char = p;code = 112
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char = i;code = 105
char = n;code = 110
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char = D;code = 68
char = e;code = 101
char = l;code = 108
char = t;code = 116
char = a;code = 97
char = P;code = 80
char = s;code = 115
char = i;code = 105
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = p;code = 112
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = s;code = 115
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char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = t;code = 116
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char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = i;code = 105
char = t;code = 116
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char = p;code = 112
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char = p;code = 112
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char = d;code = 100
char = e;code = 101
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char = d;code = 100
char = ;code = 32
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char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
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result sql = Calcitriol, the hormonal form of vitamin D, potentiates the activity of some common anticancer drugs and agents of the anticancer immune system, including tumor necrosis factor alpha (TNFalpha). TNFalpha-induced cytotoxicity is due to both caspase-dependent and -independent pathways. Cotreatment with calcitriol enhanced both modes of TNFalpha-induced death in MCF-7 breast cancer cells. It increased caspase-3-like activity as assayed by the cleavage of poly-(ADP-ribose)polymerase and of the fluorogenic substrate ac-DEVD-AMC. It also enhanced TNFalpha-induced caspase-independent cytotoxicity in the presence of the pan-caspase inhibitor zD-2,6-dichlorobenzoyloxymethylketone. The antioxidants N-acetylcysteine, reduced glutathione, lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on TNFalpha-induced caspase activation. N-acetylcysteine and reduced glutathione also decreased caspase-independent cytotoxicity in the presence or absence of calcitriol, indicating that reactive oxygen species (ROS) have a key role in the cross talk between TNFalpha and calcitriol. Mitochondrial damage is common to both TNFalpha-induced caspase-dependent and -independent pathways and may underlie excessive production of ROS. Mitochondrial membrane potential (DeltaPsi) was assessed by the specific potential-sensitive fluorescent probe JC-1. The hormone augmented the drop in DeltaPsi and release of cytochrome c from mitochondria, induced by TNFalpha. The effect of calcitriol on DeltaPsi was mimicked by rotenone, which increased both the drop in DeltaPsi and caspase activation induced by TNFalpha. It is possible that the interaction of TNFalpha and calcitriol on the level of the mitochondria is the underlying mechanism responsible for the enhancement of TNFalpha-induced, ROS-mediated caspase-dependent and -independent cell death.
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = p;code = 112
char = a;code = 97
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char = e;code = 101
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char = d;code = 100
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char = d;code = 100
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char = d;code = 100
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char = h;code = 104
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char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = o;code = 111
char = x;code = 120
char = y;code = 121
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char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = m;code = 109
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char = o;code = 111
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char = d;code = 100
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = .;code = 46
result sql = Vitamin D enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive oxygen species and mitochondria.
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char = l;code = 108
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char = a;code = 97
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char = t;code = 116
char = o;code = 111
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char = ;code = 32
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
char = s;code = 115
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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = 6;code = 54
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char = o;code = 111
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char = o;code = 111
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char = t;code = 116
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char = h;code = 104
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char = a;code = 97
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char = d;code = 100
char = a;code = 97
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char = t;code = 116
char = s;code = 115
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char = N;code = 78
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = y;code = 121
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char = e;code = 101
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char = ;code = 32
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char = e;code = 101
char = d;code = 100
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char = a;code = 97
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char = p;code = 112
char = o;code = 111
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char = a;code = 97
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char = d;code = 100
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = o;code = 111
char = r;code = 114
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
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char = d;code = 100
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char = m;code = 109
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = l;code = 108
char = y;code = 121
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char = r;code = 114
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char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = e;code = 101
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char = e;code = 101
char = n;code = 110
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = n;code = 110
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = h;code = 104
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char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = d;code = 100
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char = u;code = 117
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char = R;code = 82
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char = S;code = 83
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char = w;code = 119
char = e;code = 101
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char = N;code = 78
char = F;code = 70
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char = p;code = 112
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char = T;code = 84
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char = a;code = 97
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char = p;code = 112
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char = J;code = 74
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char = T;code = 84
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result sql = Calcitriol, the hormonal form of vitamin D, potentiates the activity of some common anticancer drugs and agents of the anticancer immune system, including tumor necrosis factor alpha (TNFalpha). TNFalpha-induced cytotoxicity is due to both caspase-dependent and -independent pathways. Cotreatment with calcitriol enhanced both modes of TNFalpha-induced death in MCF-7 breast cancer cells. It increased caspase-3-like activity as assayed by the cleavage of poly-(ADP-ribose)polymerase and of the fluorogenic substrate ac-DEVD-AMC. It also enhanced TNFalpha-induced caspase-independent cytotoxicity in the presence of the pan-caspase inhibitor zD-2,6-dichlorobenzoyloxymethylketone. The antioxidants N-acetylcysteine, reduced glutathione, lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on TNFalpha-induced caspase activation. N-acetylcysteine and reduced glutathione also decreased caspase-independent cytotoxicity in the presence or absence of calcitriol, indicating that reactive oxygen species (ROS) have a key role in the cross talk between TNFalpha and calcitriol. Mitochondrial damage is common to both TNFalpha-induced caspase-dependent and -independent pathways and may underlie excessive production of ROS. Mitochondrial membrane potential (DeltaPsi) was assessed by the specific potential-sensitive fluorescent probe JC-1. The hormone augmented the drop in DeltaPsi and release of cytochrome c from mitochondria, induced by TNFalpha. The effect of calcitriol on DeltaPsi was mimicked by rotenone, which increased both the drop in DeltaPsi and caspase activation induced by TNFalpha. It is possible that the interaction of TNFalpha and calcitriol on the level of the mitochondria is the underlying mechanism responsible for the enhancement of TNFalpha-induced, ROS-mediated caspase-dependent and -independent cell death.
Publication: Int. J. Cancer 2003 Aug 20 ;106(2)::178-86.
Publication Date: 2003 Aug 20
Study Author(s): Weitsman, Gregory E;Ravid, Amiram;Liberman, Uri A;Koren, Ruth;
Institution: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shortcut link to this study:
Publication Date: 2003 Aug 20
Study Author(s): Weitsman, Gregory E;Ravid, Amiram;Liberman, Uri A;Koren, Ruth;
Institution: Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shortcut link to this study:
Calcitriol, the hormonal form of vitamin D, potentiates the activity of some common anticancer drugs and agents of the anticancer immune system, including tumor necrosis factor alpha (TNFalpha). TNFalpha-induced cytotoxicity is due to both caspase-dependent and -independent pathways. Cotreatment with calcitriol enhanced both modes of TNFalpha-induced death in MCF-7 breast cancer cells. It increased caspase-3-like activity as assayed by the cleavage of poly-(ADP-ribose)polymerase and of the fluorogenic substrate ac-DEVD-AMC. It also enhanced TNFalpha-induced caspase-independent cytotoxicity in the presence of the pan-caspase inhibitor zD-2,6-dichlorobenzoyloxymethylketone. The antioxidants N-acetylcysteine, reduced glutathione, lipoic acid and ascorbic acid markedly reduced the enhancing effect of the hormone on TNFalpha-induced caspase activation. N-acetylcysteine and reduced glutathione also decreased caspase-independent cytotoxicity in the presence or absence of calcitriol, indicating that reactive oxygen species (ROS) have a key role in the cross talk between TNFalpha and calcitriol. Mitochondrial damage is common to both TNFalpha-induced caspase-dependent and -independent pathways and may underlie excessive production of ROS. Mitochondrial membrane potential (DeltaPsi) was assessed by the specific potential-sensitive fluorescent probe JC-1. The hormone augmented the drop in DeltaPsi and release of cytochrome c from mitochondria, induced by TNFalpha. The effect of calcitriol on DeltaPsi was mimicked by rotenone, which increased both the drop in DeltaPsi and caspase activation induced by TNFalpha. It is possible that the interaction of TNFalpha and calcitriol on the level of the mitochondria is the underlying mechanism responsible for the enhancement of TNFalpha-induced, ROS-mediated caspase-dependent and -independent cell death.
PMID: 12800192
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