|
|
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result sql = Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro.
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char = d;code = 100
char = ;code = 32
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char = M;code = 77
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char = T;code = 84
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char = a;code = 97
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char = s;code = 115
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result sql = AIM : To study the effects of daidzein on human pancreatic cancer cells in vitro.
METHODS : Human estrogen-receptor (ER)-positive pancreatic cancer cells MiaPaCa-2 and ER-negative pancreatic cancer cells PANC-1 were treated by 0.1 micromol/L, 1 micromol/L, 10 microL, 25 microL, 50 microL, 75 microL and 100 microL of daidzein, respectively. Its antiproliferative effect was studied by MTT assay.
RESULTS : Daidzein inhibited the growth of MiaPaCa-2 and PANC-1 cells at the concentrations from 0.1 microL to 100 microL. A dose- and time-dependent manner was found. The IC(50) of daidzein on MiaPaCa-2 and PANC-1 cells was 45 microL and 75 micro, respectively. After MiaPaCa-2 cells were treated by daidzein for 3 d and at the concentrations more than IC(50), the inhibitory manner was identical and the inhibition appeared a saturation phenomenon, but the inhibitory manner of daidzein on PANC-1 cells was different from that of MiaPaCa-2 cells.
CONCLUSION : Daidzein has antiproliferative effects on human estrogen-receptor-positive and negative pancreatic cancer cells, but their mechanisms may be different.
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result sql = Effects of daidzein on estrogen-receptor-positive and negative pancreatic cancer cells in vitro.
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char = a;code = 97
char = t;code = 116
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char = A;code = 65
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char = c;code = 99
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char = l;code = 108
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char = ;code = 32
char = d;code = 100
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char = f;code = 102
char = f;code = 102
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char = f;code = 102
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char = o;code = 111
char = m;code = 109
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char = a;code = 97
char = t;code = 116
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char = M;code = 77
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char = P;code = 80
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char = C;code = 67
char = a;code = 97
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char = l;code = 108
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char = <;code = 60
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char = b;code = 98
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char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
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char = S;code = 83
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char = O;code = 79
char = N;code = 78
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char = d;code = 100
char = z;code = 122
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char = v;code = 118
char = e;code = 101
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char = e;code = 101
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char = c;code = 99
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = ;code = 32
char = c;code = 99
char = e;code = 101
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char = l;code = 108
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char = u;code = 117
char = t;code = 116
char = ;code = 32
char = t;code = 116
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char = i;code = 105
char = r;code = 114
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char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
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result sql = AIM : To study the effects of daidzein on human pancreatic cancer cells in vitro.
METHODS : Human estrogen-receptor (ER)-positive pancreatic cancer cells MiaPaCa-2 and ER-negative pancreatic cancer cells PANC-1 were treated by 0.1 micromol/L, 1 micromol/L, 10 microL, 25 microL, 50 microL, 75 microL and 100 microL of daidzein, respectively. Its antiproliferative effect was studied by MTT assay.
RESULTS : Daidzein inhibited the growth of MiaPaCa-2 and PANC-1 cells at the concentrations from 0.1 microL to 100 microL. A dose- and time-dependent manner was found. The IC(50) of daidzein on MiaPaCa-2 and PANC-1 cells was 45 microL and 75 micro, respectively. After MiaPaCa-2 cells were treated by daidzein for 3 d and at the concentrations more than IC(50), the inhibitory manner was identical and the inhibition appeared a saturation phenomenon, but the inhibitory manner of daidzein on PANC-1 cells was different from that of MiaPaCa-2 cells.
CONCLUSION : Daidzein has antiproliferative effects on human estrogen-receptor-positive and negative pancreatic cancer cells, but their mechanisms may be different.
Publication: World J. Gastroenterol. 2004 Mar 15 ;10(6)::860-3.
Publication Date: 2004 Mar 15
Study Author(s): Guo, Jun-Ming;Xiao, Bing-Xiu;Dai, De-Jian;Liu, Qiong;Ma, Hong-Hui;
Institution: School of Medicine, Ningbo University, Ningbo 315211, Zhejiang Province, China. [email protected]
Shortcut link to this study:
Publication Date: 2004 Mar 15
Study Author(s): Guo, Jun-Ming;Xiao, Bing-Xiu;Dai, De-Jian;Liu, Qiong;Ma, Hong-Hui;
Institution: School of Medicine, Ningbo University, Ningbo 315211, Zhejiang Province, China. [email protected]
Shortcut link to this study:
AIM : To study the effects of daidzein on human pancreatic cancer cells in vitro.
METHODS : Human estrogen-receptor (ER)-positive pancreatic cancer cells MiaPaCa-2 and ER-negative pancreatic cancer cells PANC-1 were treated by 0.1 micromol/L, 1 micromol/L, 10 microL, 25 microL, 50 microL, 75 microL and 100 microL of daidzein, respectively. Its antiproliferative effect was studied by MTT assay.
RESULTS : Daidzein inhibited the growth of MiaPaCa-2 and PANC-1 cells at the concentrations from 0.1 microL to 100 microL. A dose- and time-dependent manner was found. The IC(50) of daidzein on MiaPaCa-2 and PANC-1 cells was 45 microL and 75 micro, respectively. After MiaPaCa-2 cells were treated by daidzein for 3 d and at the concentrations more than IC(50), the inhibitory manner was identical and the inhibition appeared a saturation phenomenon, but the inhibitory manner of daidzein on PANC-1 cells was different from that of MiaPaCa-2 cells.
CONCLUSION : Daidzein has antiproliferative effects on human estrogen-receptor-positive and negative pancreatic cancer cells, but their mechanisms may be different.
METHODS : Human estrogen-receptor (ER)-positive pancreatic cancer cells MiaPaCa-2 and ER-negative pancreatic cancer cells PANC-1 were treated by 0.1 micromol/L, 1 micromol/L, 10 microL, 25 microL, 50 microL, 75 microL and 100 microL of daidzein, respectively. Its antiproliferative effect was studied by MTT assay.
RESULTS : Daidzein inhibited the growth of MiaPaCa-2 and PANC-1 cells at the concentrations from 0.1 microL to 100 microL. A dose- and time-dependent manner was found. The IC(50) of daidzein on MiaPaCa-2 and PANC-1 cells was 45 microL and 75 micro, respectively. After MiaPaCa-2 cells were treated by daidzein for 3 d and at the concentrations more than IC(50), the inhibitory manner was identical and the inhibition appeared a saturation phenomenon, but the inhibitory manner of daidzein on PANC-1 cells was different from that of MiaPaCa-2 cells.
CONCLUSION : Daidzein has antiproliferative effects on human estrogen-receptor-positive and negative pancreatic cancer cells, but their mechanisms may be different.
PMID: 15040033
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