|
|
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char = a;code = 97
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char = h;code = 104
char = i;code = 105
char = o;code = 111
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char = f;code = 102
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result sql = Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells.
Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells.char = P;code = 80
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char = s;code = 115
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char = t;code = 116
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char = a;code = 97
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char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
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char = o;code = 111
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = i;code = 105
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char = T;code = 84
char = h;code = 104
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char = r;code = 114
char = e;code = 101
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char = w;code = 119
char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = s;code = 115
char = i;code = 105
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char = n;code = 110
char = i;code = 105
char = f;code = 102
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char = c;code = 99
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char = c;code = 99
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char = i;code = 105
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char = o;code = 111
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char = ;code = 32
char = G;code = 71
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char = u;code = 117
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char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
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char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = (;code = 40
char = G;code = 71
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = i;code = 105
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char = H;code = 72
char = K;code = 75
char = 1;code = 49
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char = a;code = 97
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char = ;code = 32
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char = t;code = 116
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char = K;code = 75
char = 1;code = 49
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char = o;code = 111
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char = i;code = 105
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char = t;code = 116
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char = t;code = 116
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char = e;code = 101
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char = e;code = 101
char = r;code = 114
char = i;code = 105
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char = .;code = 46
char = <;code = 60
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char = /;code = 47
char = >;code = 62
result sql = Photodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment.
char = h;code = 104
char = o;code = 111
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char = o;code = 111
char = a;code = 97
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char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = d;code = 100
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char = n;code = 110
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = g;code = 103
char = l;code = 108
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = S;code = 83
char = -;code = 45
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char = r;code = 114
char = a;code = 97
char = n;code = 110
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char = a;code = 97
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char = o;code = 111
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = .;code = 46
result sql = Photoactivation of hypericin down-regulates glutathione S-transferase activity in nasopharyngeal cancer cells.
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result sql = Photodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment.
Publication: Cancer Lett. 2004 Apr 30 ;207(2)::175-81.
Publication Date: 2004 Apr 30
Study Author(s): Du, H Y;Olivo, M;Tan, B K H;Bay, B H;
Institution: Department of Anatomy, Faculty of Medicine, National University of Singapore, 4 Medical Drive, MD 10, Singapore, Singapore S117 597.
Shortcut link to this study:
Publication Date: 2004 Apr 30
Study Author(s): Du, H Y;Olivo, M;Tan, B K H;Bay, B H;
Institution: Department of Anatomy, Faculty of Medicine, National University of Singapore, 4 Medical Drive, MD 10, Singapore, Singapore S117 597.
Shortcut link to this study:
Photodynamic therapy (PDT) is a new modality of treatment for cancer. Hypericin is a photosensitizer, which is known to generate reactive oxygen species upon activation with light. We observed that photoactivated hypericin induces the generation of reactive oxygen intermediates in nasopharyngeal cancer (NPC) cells in vitro. There was also significant reduction of Glutathione S-transferase (GST) activity in HK1 and CNE-2 NPC cells and in tumor tissues from the NPC/HK1 murine tumor model by hypericin-mediated PDT. As antioxidants protect cells against phototoxicity, down-regulation of GST activity would potentiate the efficacy of hypericin-PDT treatment.
PMID: 15072826
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