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result sql = Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-disubstituted ureas.
Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-disubstituted ureas.
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char = u;code = 117
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char = n;code = 110
char = g;code = 103
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char = ;code = 32
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char = i;code = 105
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char = ;code = 32
char = s;code = 115
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char = h;code = 104
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char = e;code = 101
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char = u;code = 117
char = s;code = 115
char = i;code = 105
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char = g;code = 103
char = ;code = 32
char = b;code = 98
char = o;code = 111
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char = h;code = 104
char = ;code = 32
char = s;code = 115
char = o;code = 111
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char = u;code = 117
char = t;code = 116
char = i;code = 105
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char = h;code = 104
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char = e;code = 101
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char = a;code = 97
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = a;code = 97
char = c;code = 99
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char = s;code = 115
char = .;code = 46
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char = ;code = 32
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = o;code = 111
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char = t;code = 116
char = e;code = 101
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char = s;code = 115
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char = e;code = 101
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = e;code = 101
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
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char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = o;code = 111
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char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = m;code = 109
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char = t;code = 116
char = h;code = 104
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = -;code = 45
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = H;code = 72
char = I;code = 73
char = V;code = 86
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = r;code = 114
char = u;code = 117
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char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = A series of lysine sulfonamide analogues bearing a Nepsilon-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nalpha-(alkyl)-Nalpha-(sulfonamides)lysinol using alpha-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.

Publication: Bioorg. Med. Chem. Lett. 2004 Aug 2 ;14(15)::3971-4.
Publication Date: 2004 Aug 2
Study Author(s): Stranix, Brent R;Sauvé, Gilles;Bouzide, Abderrahim;Coté, Alexandre;Sévigny, Guy;Yelle, Jocelyn;Perron, Valérie;
Institution: Procyon Biopharma Inc., 1650 Trans-Canada Highway, Suite 200, Dorval, Quebec, Canada, H9P 1H7. [email protected]
Shortcut link to this study:

A series of lysine sulfonamide analogues bearing a Nepsilon-benzylic ureas was synthesized using both solution-phase and solid-phase approaches. A novel synthetic route of Nalpha-(alkyl)-Nalpha-(sulfonamides)lysinol using alpha-amino-caprolactam was developed. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type HIV virus.

PMID: 15225709

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