|
|
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char = l;code = 108
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result sql = Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line.
Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line.char = W;code = 87
char = e;code = 101
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char = g;code = 103
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char = h;code = 104
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char = .;code = 46
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char = ;code = 32
char = B;code = 66
char = A;code = 65
char = P;code = 80
char = T;code = 84
char = A;code = 65
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char = A;code = 65
char = M;code = 77
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char = ;code = 32
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char = i;code = 105
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char = f;code = 102
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result sql = We have investigated the ionophoretic and apoptotic properties of the daucane sesquiterpene ferutinin and three related compounds, ferutidin, 2-alpha-hydroxyferutidin and teferin, all isolated from various species of plants from the genus Ferula. Ferutinin induced a biphasic elevation of intracellular Ca2+ in the leukemia T-cell line, Jurkat. First, a rapid calcium peak was observed and inhibited by BAPTA-AM. This initial calcium mobilization was followed by a sustained elevation, mediated by the entry of extracellular calcium through L-type calcium channels and sensitive to inhibition by EGTA. Moreover, ferutinin-induced apoptosis in Jurkat cells, and this event was preceded, in a cyclosporine-A sensitive manner, by a loss of mitochondrial transmembrane potential (DeltaPsim) and by an increase in intracellular reactive oxygen species. Ferutinin-induced DNA fragmentation was mediated by a caspase-3-dependent pathway, and was initiated independently of any specific phase of the cell cycle. The evaluation of ferutinin analogs in calcium mobilization and apoptosis assays showed strict structure-activity relationships, with p-hydroxylation of the benzoyl moiety being requested for activity.
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char = l;code = 108
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char = l;code = 108
char = i;code = 105
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char = e;code = 101
char = .;code = 46
result sql = Calcium ionophoretic and apoptotic effects of ferutinin in the human Jurkat T-cell line.
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result sql = We have investigated the ionophoretic and apoptotic properties of the daucane sesquiterpene ferutinin and three related compounds, ferutidin, 2-alpha-hydroxyferutidin and teferin, all isolated from various species of plants from the genus Ferula. Ferutinin induced a biphasic elevation of intracellular Ca2+ in the leukemia T-cell line, Jurkat. First, a rapid calcium peak was observed and inhibited by BAPTA-AM. This initial calcium mobilization was followed by a sustained elevation, mediated by the entry of extracellular calcium through L-type calcium channels and sensitive to inhibition by EGTA. Moreover, ferutinin-induced apoptosis in Jurkat cells, and this event was preceded, in a cyclosporine-A sensitive manner, by a loss of mitochondrial transmembrane potential (DeltaPsim) and by an increase in intracellular reactive oxygen species. Ferutinin-induced DNA fragmentation was mediated by a caspase-3-dependent pathway, and was initiated independently of any specific phase of the cell cycle. The evaluation of ferutinin analogs in calcium mobilization and apoptosis assays showed strict structure-activity relationships, with p-hydroxylation of the benzoyl moiety being requested for activity.
Publication: Biochem. Pharmacol. 2004 Sep 1 ;68(5)::875-83.
Publication Date: 2004 Sep 1
Study Author(s): Macho, Antonio;Blanco-Molina, Magdalena;Spagliardi, Paola;Appendino, Giovanni;Bremner, Paul;Heinrich, Michael;Fiebich, Bernd L;Muñoz, Eduardo;
Institution: Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Facultad de Medicina, Avda. de Menendez Pidal s/n, E-14004 Córdoba, Spain.
Shortcut link to this study:
Publication Date: 2004 Sep 1
Study Author(s): Macho, Antonio;Blanco-Molina, Magdalena;Spagliardi, Paola;Appendino, Giovanni;Bremner, Paul;Heinrich, Michael;Fiebich, Bernd L;Muñoz, Eduardo;
Institution: Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Facultad de Medicina, Avda. de Menendez Pidal s/n, E-14004 Córdoba, Spain.
Shortcut link to this study:
We have investigated the ionophoretic and apoptotic properties of the daucane sesquiterpene ferutinin and three related compounds, ferutidin, 2-alpha-hydroxyferutidin and teferin, all isolated from various species of plants from the genus Ferula. Ferutinin induced a biphasic elevation of intracellular Ca2+ in the leukemia T-cell line, Jurkat. First, a rapid calcium peak was observed and inhibited by BAPTA-AM. This initial calcium mobilization was followed by a sustained elevation, mediated by the entry of extracellular calcium through L-type calcium channels and sensitive to inhibition by EGTA. Moreover, ferutinin-induced apoptosis in Jurkat cells, and this event was preceded, in a cyclosporine-A sensitive manner, by a loss of mitochondrial transmembrane potential (DeltaPsim) and by an increase in intracellular reactive oxygen species. Ferutinin-induced DNA fragmentation was mediated by a caspase-3-dependent pathway, and was initiated independently of any specific phase of the cell cycle. The evaluation of ferutinin analogs in calcium mobilization and apoptosis assays showed strict structure-activity relationships, with p-hydroxylation of the benzoyl moiety being requested for activity.
PMID: 15294450
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