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result sql = Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances.

Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances.

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char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = f;code = 102
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char = r;code = 114
char = ;code = 32
char = 7;code = 55
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char = %;code = 37
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char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = u;code = 117
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char = c;code = 99
char = a;code = 97
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char = o;code = 111
char = t;code = 116
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char = s;code = 115
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char = a;code = 97
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char = d;code = 100
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char = t;code = 116
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char = a;code = 97
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char = c;code = 99
char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = s;code = 115
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char = t;code = 116
char = a;code = 97
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char = d;code = 100
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char = s;code = 115
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char = g;code = 103
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
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char = q;code = 113
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = o;code = 111
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = E;code = 69
char = .;code = 46
char = ;code = 32
char = A;code = 65
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char = a;code = 97
char = c;code = 99
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = c;code = 99
char = o;code = 111
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char = t;code = 116
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char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = t;code = 116
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char = e;code = 101
char = s;code = 115
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char = c;code = 99
char = a;code = 97
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = o;code = 111
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = o;code = 111
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = s;code = 115
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
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char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = b;code = 98
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = -;code = 45
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char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = L;code = 76
char = N;code = 78
char = C;code = 67
char = a;code = 97
char = P;code = 80
char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = p;code = 112
char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = C;code = 67
char = -;code = 45
char = 3;code = 51
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char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = c;code = 99
char = u;code = 117
char = b;code = 98
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = -;code = 45
char = 3;code = 51
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = o;code = 111
char = c;code = 99
char = a;code = 97
char = d;code = 100
char = o;code = 111
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char = e;code = 101
char = x;code = 120
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = G;code = 71
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char = 2;code = 50
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char = /;code = 47
char = M;code = 77
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
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char = e;code = 101
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char = a;code = 97
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char = r;code = 114
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char = s;code = 115
char = t;code = 116
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char = c;code = 99
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char = 7;code = 55
char = ;code = 32
char = p;code = 112
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char = e;code = 101
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char = n;code = 110
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char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = L;code = 76
char = u;code = 117
char = t;code = 116
char = e;code = 101
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char = n;code = 110
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char = a;code = 97
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char = e;code = 101
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char = r;code = 114
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char = p;code = 112
char = r;code = 114
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char = u;code = 117
char = c;code = 99
char = e;code = 101
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char = t;code = 116
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = o;code = 111
char = c;code = 99
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char = t;code = 116
char = r;code = 114
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = n;code = 110
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = c;code = 99
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char = l;code = 108
char = o;code = 111
char = r;code = 114
char = f;code = 102
char = u;code = 117
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = e;code = 101
char = g;code = 103
char = e;code = 101
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char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = o;code = 111
char = c;code = 99
char = a;code = 97
char = d;code = 100
char = o;code = 111
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char = c;code = 99
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char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = m;code = 109
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = s;code = 115
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char = b;code = 98
char = i;code = 105
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char = a;code = 97
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char = v;code = 118
char = e;code = 101
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char = c;code = 99
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char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = o;code = 111
char = i;code = 105
char = d;code = 100
char = s;code = 115
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char = ;code = 32
char = B;code = 66
char = e;code = 101
char = c;code = 99
char = a;code = 97
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char = s;code = 115
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = o;code = 111
char = c;code = 99
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char = i;code = 105
char = k;code = 107
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = o;code = 111
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char = t;code = 116
char = h;code = 104
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char = b;code = 98
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char = e;code = 101
char = a;code = 97
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char = h;code = 104
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char = r;code = 114
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char = o;code = 111
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char = w;code = 119
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char = t;code = 116
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char = h;code = 104
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char = e;code = 101
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char = v;code = 118
char = e;code = 101
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char = p;code = 112
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char = y;code = 121
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char = c;code = 99
char = a;code = 97
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char = t;code = 116
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char = e;code = 101
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char = a;code = 97
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char = c;code = 99
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char = b;code = 98
char = u;code = 117
char = t;code = 116
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char = t;code = 116
char = o;code = 111
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char = t;code = 116
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char = e;code = 101
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char = g;code = 103
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char = f;code = 102
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = i;code = 105
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result sql = Although the avocado is known as a rich source of monounsaturated fatty acids, there has been far less attention given to its content of other bioactive substances including carotenoids, which might contribute to cancer preventive properties similar to those attributed to other fruits and vegetables. The yellow-green color of the avocado prompted us to study the carotenoid content of this fruit using established methods in our laboratory. The California Hass avocado (Persea americana Mill.) was selected for study, because it is the most commonly consumed variety in the southwest United States. These avocados were found to contain the highest content of lutein among commonly eaten fruits as well as measurable amounts of related carotenoids (zeaxanthin, alpha-carotene, and beta-carotene). Lutein accounted for 70% of the measured carotenoids, and the avocado also contained significant quantities of vitamin E. An acetone extract of avocado containing these carotenoids and tocopherols was shown to inhibit the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines in vitro. Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27 protein expression. Lutein alone did not reproduce the effects of the avocado extract on cancer cell proliferation. In common with other colorful fruits and vegetables, the avocado contains numerous bioactive carotenoids. Because the avocado also contains a significant amount of monounsaturated fat, these bioactive carotenoids are likely to be absorbed into the bloodstream, where in combination with other diet-derived phytochemicals they may contribute to the significant cancer risk reduction associated with a diet of fruits and vegetables.

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