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result sql = Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT).
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result sql = Prostate cancer continues to be a major health threat, especially among African American men. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), which opened on July 25, 2001, was planned to study possible agents for the prevention of prostate cancer in a population of 32,400 men in the United States, including Puerto Rico, and Canada SELECT : is a phase III randomized, placebo-controlled trial of selenium (200 microg/day from L-selenomethionine) and/or vitamin E (400 IU/day of all rac alpha-tocopheryl acetate) supplementation for a minimum of 7 years (maximum of 12 years) in non-African American men at least 55 years of age and African American men at least 50 years of age SELECT : is a large, simple trial that conforms as closely as possible with community standards of care. This commentary discusses the design problems the SELECT investigators had to resolve in developing the trial, including the role of prostate cancer screening, the best forms and doses of the study agents, and estimation of the event (prostate cancer) rate of men on the placebo arm.

Publication: J. Natl. Cancer Inst. 2005 Jan 19 ;97(2)::94-102.
Publication Date: 2005 Jan 19
Study Author(s): Lippman, Scott M;Goodman, Phyllis J;Klein, Eric A;Parnes, Howard L;Thompson, Ian M;Kristal, Alan R;Santella, Regina M;Probstfield, Jeffrey L;Moinpour, Carol M;Albanes, Demetrius;Taylor, Philip R;Minasian, Lori M;Hoque, Ashraful;Thomas, Sarah Moody;Crowley, John J;Gaziano, J Michael;Stanford, Janet L;Cook, Elise D;Fleshner, Neil E;Lieber, Michael M;Walther, Philip J;Khuri, Fadlo R;Karp, Daniel D;Schwartz, Gary G;Ford, Leslie G;Coltman, Charles A;
Institution: The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. [email protected]
Shortcut link to this study:
Prostate cancer continues to be a major health threat, especially among African American men. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), which opened on July 25, 2001, was planned to study possible agents for the prevention of prostate cancer in a population of 32,400 men in the United States, including Puerto Rico, and Canada SELECT : is a phase III randomized, placebo-controlled trial of selenium (200 microg/day from L-selenomethionine) and/or vitamin E (400 IU/day of all rac alpha-tocopheryl acetate) supplementation for a minimum of 7 years (maximum of 12 years) in non-African American men at least 55 years of age and African American men at least 50 years of age SELECT : is a large, simple trial that conforms as closely as possible with community standards of care. This commentary discusses the design problems the SELECT investigators had to resolve in developing the trial, including the role of prostate cancer screening, the best forms and doses of the study agents, and estimation of the event (prostate cancer) rate of men on the placebo arm.
PMID: 15657339

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