|
|
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result sql = Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation.
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = F;code = 70
char = A;code = 65
char = F;code = 70
char = 1;code = 49
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = m;code = 109
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char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = c;code = 99
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = E;code = 69
char = D;code = 68
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = F;code = 70
char = A;code = 65
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char = D;code = 68
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char = p;code = 112
char = a;code = 97
char = s;code = 115
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char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = D;code = 68
char = E;code = 69
char = F;code = 70
char = ;code = 32
char = a;code = 97
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char = s;code = 115
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char = s;code = 115
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char = e;code = 101
char = v;code = 118
char = e;code = 101
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char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
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char = s;code = 115
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char = t;code = 116
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char = E;code = 69
char = F;code = 70
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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char = w;code = 119
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char = t;code = 116
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char = ;code = 32
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char = p;code = 112
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char = s;code = 115
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char = e;code = 101
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char = f;code = 102
char = o;code = 111
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char = ;code = 32
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char = h;code = 104
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
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char = o;code = 111
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = s;code = 115
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char = t;code = 116
char = i;code = 105
char = z;code = 122
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = s;code = 115
char = s;code = 115
char = e;code = 101
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result sql = Fas-associated factor-1 (FAF1) is a newly introduced member of the Fas death-inducing signaling complex and potentiates Fas-mediated apoptosis. Clinical study has revealed that FAF1 is significantly reduced in gastric carcinomas. The present study demonstrates that FAF1 mediates chemotherapeutic-induced apoptosis via participation in the formation of death effector filament (DEF), a cytoskeleton-like structure found in receptor-independent apoptosis. Overexpression of FAF1 enhanced DEF assembly and cell death induced by chemotherapeutics such as staurosporine (STS), cisplatin (CDDP) and etoposide (VP16). FAF1 sensitized cells to STS, CDDP and VP16 in dose- and time-dependent manner. Introduction of antisense FAF1 construct inhibited DEF assembly and chemotherapeutic-induced apoptosis. Analysis using FAF1 truncates showed that the FAF1 domain interacting with DEDs of FADD and caspase-8 was sufficient to enhance DEF assembly. Confocal microscopy revealed that FAF1 was present in DEFs together with FADD and caspase-8. Collectively, our data provide a molecular mechanism for the chemosensitization by FAF1 (i.e., mediating DEF assembly).
char = a;code = 97
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = 1;code = 49
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
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char = e;code = 101
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = f;code = 102
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char = m;code = 109
char = e;code = 101
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char = f;code = 102
char = o;code = 111
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char = m;code = 109
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation.
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char = s;code = 115
char = -;code = 45
char = a;code = 97
char = s;code = 115
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char = a;code = 97
char = c;code = 99
char = t;code = 116
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result sql = Fas-associated factor-1 (FAF1) is a newly introduced member of the Fas death-inducing signaling complex and potentiates Fas-mediated apoptosis. Clinical study has revealed that FAF1 is significantly reduced in gastric carcinomas. The present study demonstrates that FAF1 mediates chemotherapeutic-induced apoptosis via participation in the formation of death effector filament (DEF), a cytoskeleton-like structure found in receptor-independent apoptosis. Overexpression of FAF1 enhanced DEF assembly and cell death induced by chemotherapeutics such as staurosporine (STS), cisplatin (CDDP) and etoposide (VP16). FAF1 sensitized cells to STS, CDDP and VP16 in dose- and time-dependent manner. Introduction of antisense FAF1 construct inhibited DEF assembly and chemotherapeutic-induced apoptosis. Analysis using FAF1 truncates showed that the FAF1 domain interacting with DEDs of FADD and caspase-8 was sufficient to enhance DEF assembly. Confocal microscopy revealed that FAF1 was present in DEFs together with FADD and caspase-8. Collectively, our data provide a molecular mechanism for the chemosensitization by FAF1 (i.e., mediating DEF assembly).
Publication: Int. J. Cancer 2005 Jun 20 ;115(3)::412-8.
Publication Date: 2005 Jun 20
Study Author(s): Park, Min-Young;Ryu, Seung-Wook;Kim, Kwang Dong;Lim, Jong-Seok;Lee, Zee-Won;Kim, Eunhee;
Institution: Research Center for Biomedicinal Resources and Department of Genetic Engineering, PaiChai University, Daejeon, Korea.
Shortcut link to this study:
Publication Date: 2005 Jun 20
Study Author(s): Park, Min-Young;Ryu, Seung-Wook;Kim, Kwang Dong;Lim, Jong-Seok;Lee, Zee-Won;Kim, Eunhee;
Institution: Research Center for Biomedicinal Resources and Department of Genetic Engineering, PaiChai University, Daejeon, Korea.
Shortcut link to this study:
Fas-associated factor-1 (FAF1) is a newly introduced member of the Fas death-inducing signaling complex and potentiates Fas-mediated apoptosis. Clinical study has revealed that FAF1 is significantly reduced in gastric carcinomas. The present study demonstrates that FAF1 mediates chemotherapeutic-induced apoptosis via participation in the formation of death effector filament (DEF), a cytoskeleton-like structure found in receptor-independent apoptosis. Overexpression of FAF1 enhanced DEF assembly and cell death induced by chemotherapeutics such as staurosporine (STS), cisplatin (CDDP) and etoposide (VP16). FAF1 sensitized cells to STS, CDDP and VP16 in dose- and time-dependent manner. Introduction of antisense FAF1 construct inhibited DEF assembly and chemotherapeutic-induced apoptosis. Analysis using FAF1 truncates showed that the FAF1 domain interacting with DEDs of FADD and caspase-8 was sufficient to enhance DEF assembly. Confocal microscopy revealed that FAF1 was present in DEFs together with FADD and caspase-8. Collectively, our data provide a molecular mechanism for the chemosensitization by FAF1 (i.e., mediating DEF assembly).
PMID: 15688372
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