|
|
char = S;code = 83
char = e;code = 101
char = l;code = 108
char = e;code = 101
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char = d;code = 100
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
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char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = a;code = 97
char = l;code = 108
char = i;code = 105
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char = e;code = 101
char = c;code = 99
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char = x;code = 120
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char = s;code = 115
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = l;code = 108
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char = g;code = 103
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char = d;code = 100
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char = d;code = 100
char = i;code = 105
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char = g;code = 103
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = .;code = 46
result sql = Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells.
Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells.char = C;code = 67
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char = n;code = 110
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char = ;code = 32
char = s;code = 115
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char = g;code = 103
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char = m;code = 109
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char = d;code = 100
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char = e;code = 101
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char = d;code = 100
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char = g;code = 103
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = r;code = 114
char = e;code = 101
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char = i;code = 105
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char = u;code = 117
char = s;code = 115
char = ;code = 32
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char = e;code = 101
char = p;code = 112
char = o;code = 111
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char = t;code = 116
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char = s;code = 115
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char = o;code = 111
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char = a;code = 97
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char = M;code = 77
char = C;code = 67
char = F;code = 70
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char = 1;code = 49
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char = c;code = 99
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char = s;code = 115
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char = .;code = 46
char = ;code = 32
char = B;code = 66
char = e;code = 101
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char = i;code = 105
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char = i;code = 105
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char = f;code = 102
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char = m;code = 109
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char = a;code = 97
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result sql = Cancer prevention studies suggest that selenium is effective in reducing the incidence of cancers including prostate, colon, and lung cancers. Previous reports showed that selenium inhibits premalignant human breast MCF-10AT1 and MCF10AT3B cell growth in vitro and reduces mammary tumor incidence after exposure to carcinogens in tumor models. Because estrogen is critical to the development and differentiation of estrogen target tissues, including the breast, the present study was designed to examine the effect of selenium on estrogen receptor (ER) expression and activation using methylseleninic acid (MSA), an active form of selenium in vitro. Selenium decreased the levels of expression of ERalpha mRNA and protein and reduced the binding of labeled estradiol to estrogen receptor in MCF-7 cells. Selenium inhibited the trans-activating activity of estrogen receptor in MCF-7 cells expressing functional estrogen receptor using a luciferase reporter construct linked to estrogen responsive element. Selenium decreased the binding of estrogen receptor to the estrogen responsive element site using an electrophoretic mobility gel shift assay. Selenium suppressed estrogen induction of the endogenous target gene c-myc. In contrast to the effect on ERalpha in MCF-7 cells, selenium increased ERbeta mRNA expression in MDA-MB231 human breast cancer cells. Thus, differential regulation of ERalpha and ERbeta in breast cancer cells may represent a novel mechanism of selenium action and provide a rationale for selenium breast cancer prevention trial.
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result sql = Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells.
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result sql = Cancer prevention studies suggest that selenium is effective in reducing the incidence of cancers including prostate, colon, and lung cancers. Previous reports showed that selenium inhibits premalignant human breast MCF-10AT1 and MCF10AT3B cell growth in vitro and reduces mammary tumor incidence after exposure to carcinogens in tumor models. Because estrogen is critical to the development and differentiation of estrogen target tissues, including the breast, the present study was designed to examine the effect of selenium on estrogen receptor (ER) expression and activation using methylseleninic acid (MSA), an active form of selenium in vitro. Selenium decreased the levels of expression of ERalpha mRNA and protein and reduced the binding of labeled estradiol to estrogen receptor in MCF-7 cells. Selenium inhibited the trans-activating activity of estrogen receptor in MCF-7 cells expressing functional estrogen receptor using a luciferase reporter construct linked to estrogen responsive element. Selenium decreased the binding of estrogen receptor to the estrogen responsive element site using an electrophoretic mobility gel shift assay. Selenium suppressed estrogen induction of the endogenous target gene c-myc. In contrast to the effect on ERalpha in MCF-7 cells, selenium increased ERbeta mRNA expression in MDA-MB231 human breast cancer cells. Thus, differential regulation of ERalpha and ERbeta in breast cancer cells may represent a novel mechanism of selenium action and provide a rationale for selenium breast cancer prevention trial.
Publication: Cancer Res. 2005 Apr 15 ;65(8)::3487-92.
Publication Date: 2005 Apr 15
Study Author(s): Lee, Soo Ok;Nadiminty, Nagalakshmi;Wu, Xiu Xian;Lou, Wei;Dong, Yan;Ip, Clement;Onate, Sergio A;Gao, Allen C;
Institution: Department of Medicine, Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, NY 14263, USA.
Shortcut link to this study:
Publication Date: 2005 Apr 15
Study Author(s): Lee, Soo Ok;Nadiminty, Nagalakshmi;Wu, Xiu Xian;Lou, Wei;Dong, Yan;Ip, Clement;Onate, Sergio A;Gao, Allen C;
Institution: Department of Medicine, Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, NY 14263, USA.
Shortcut link to this study:
Cancer prevention studies suggest that selenium is effective in reducing the incidence of cancers including prostate, colon, and lung cancers. Previous reports showed that selenium inhibits premalignant human breast MCF-10AT1 and MCF10AT3B cell growth in vitro and reduces mammary tumor incidence after exposure to carcinogens in tumor models. Because estrogen is critical to the development and differentiation of estrogen target tissues, including the breast, the present study was designed to examine the effect of selenium on estrogen receptor (ER) expression and activation using methylseleninic acid (MSA), an active form of selenium in vitro. Selenium decreased the levels of expression of ERalpha mRNA and protein and reduced the binding of labeled estradiol to estrogen receptor in MCF-7 cells. Selenium inhibited the trans-activating activity of estrogen receptor in MCF-7 cells expressing functional estrogen receptor using a luciferase reporter construct linked to estrogen responsive element. Selenium decreased the binding of estrogen receptor to the estrogen responsive element site using an electrophoretic mobility gel shift assay. Selenium suppressed estrogen induction of the endogenous target gene c-myc. In contrast to the effect on ERalpha in MCF-7 cells, selenium increased ERbeta mRNA expression in MDA-MB231 human breast cancer cells. Thus, differential regulation of ERalpha and ERbeta in breast cancer cells may represent a novel mechanism of selenium action and provide a rationale for selenium breast cancer prevention trial.
PMID: 15833885
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