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result sql = Clinical trials using chemopreventive vitamin D analogs in breast cancer.
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result sql = This article comprehensively reviews the clinical trials and considers the future directions of the use of vitamin D and its analogs in the treatment or chemoprevention of breast cancer. Chemopreventive treatment strategies strive to delay the onset of certain cancers, prevent the progression of malignant disease after diagnosis, or delay the advent of recurrence after curative treatment. We first summarize the epidemiological evidence that led to the hypothesis that vitamin D may have an anti-cancer activity. Vitamin D shows great potential as a therapy for breast cancer; however, its use in clinical trials has been hindered by the induction of hypercalcemia at a concentration required to suppress cancer cell proliferation. This has led to the development of less calcemic analogs of vitamin D. We review the clinical trials with breast cancer patients using vitamin D analogs.
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result sql = Clinical trials using chemopreventive vitamin D analogs in breast cancer.
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result sql = This article comprehensively reviews the clinical trials and considers the future directions of the use of vitamin D and its analogs in the treatment or chemoprevention of breast cancer. Chemopreventive treatment strategies strive to delay the onset of certain cancers, prevent the progression of malignant disease after diagnosis, or delay the advent of recurrence after curative treatment. We first summarize the epidemiological evidence that led to the hypothesis that vitamin D may have an anti-cancer activity. Vitamin D shows great potential as a therapy for breast cancer; however, its use in clinical trials has been hindered by the induction of hypercalcemia at a concentration required to suppress cancer cell proliferation. This has led to the development of less calcemic analogs of vitamin D. We review the clinical trials with breast cancer patients using vitamin D analogs.
Publication: Cancer J 2006 Nov-Dec ;12(6)::445-50.
Publication Date: 2006 Nov-Dec
Study Author(s): Vijayakumar, Srinivasan;Boerner, Philip S;Mehta, Rajeshwari R;Packianathan, S;Mehta, Rajendra G;Das Gupta, Tapas K;
Institution: Department of Radiation Oncology, UC Davis Cancer Center, Sacramento, California 95817, USA. [email protected]
Shortcut link to this study:
Publication Date: 2006 Nov-Dec
Study Author(s): Vijayakumar, Srinivasan;Boerner, Philip S;Mehta, Rajeshwari R;Packianathan, S;Mehta, Rajendra G;Das Gupta, Tapas K;
Institution: Department of Radiation Oncology, UC Davis Cancer Center, Sacramento, California 95817, USA. [email protected]
Shortcut link to this study:
This article comprehensively reviews the clinical trials and considers the future directions of the use of vitamin D and its analogs in the treatment or chemoprevention of breast cancer. Chemopreventive treatment strategies strive to delay the onset of certain cancers, prevent the progression of malignant disease after diagnosis, or delay the advent of recurrence after curative treatment. We first summarize the epidemiological evidence that led to the hypothesis that vitamin D may have an anti-cancer activity. Vitamin D shows great potential as a therapy for breast cancer; however, its use in clinical trials has been hindered by the induction of hypercalcemia at a concentration required to suppress cancer cell proliferation. This has led to the development of less calcemic analogs of vitamin D. We review the clinical trials with breast cancer patients using vitamin D analogs.
PMID: 17207311
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