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result sql = Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies.
Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies.
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
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char = n;code = 110
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char = a;code = 97
char = ;code = 32
char = f;code = 102
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char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
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char = u;code = 117
char = p;code = 112
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 7;code = 55
char = -;code = 45
char = 2;code = 50
char = 2;code = 50
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char = y;code = 121
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char = a;code = 97
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
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char = c;code = 99
char = a;code = 97
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
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char = s;code = 115
char = k;code = 107
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
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char = a;code = 97
char = r;code = 114
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char = a;code = 97
char = n;code = 110
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = R;code = 82
char = R;code = 82
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = 9;code = 57
char = 5;code = 53
char = %;code = 37
char = ;code = 32
char = c;code = 99
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char = f;code = 102
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = a;code = 97
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char = s;code = 115
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
char = 5;code = 53
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
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char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = 6;code = 54
char = 0;code = 48
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
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char = g;code = 103
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char = d;code = 100
char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = c;code = 99
char = a;code = 97
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
char = ,;code = 44
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char = 0;code = 48
char = .;code = 46
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char = 6;code = 54
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
char = 3;code = 51
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = f;code = 102
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = 2;code = 50
char = ,;code = 44
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char = 0;code = 48
char = 0;code = 48
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = /;code = 47
char = d;code = 100
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = c;code = 99
char = a;code = 97
char = r;code = 114
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
char = 9;code = 57
char = ;code = 32
char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
char = 7;code = 55
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
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char = 1;code = 49
char = 0;code = 48
char = 0;code = 48
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
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char = g;code = 103
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char = d;code = 100
char = a;code = 97
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char = i;code = 105
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char = c;code = 99
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
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char = b;code = 98
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char = t;code = 116
char = a;code = 97
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char = c;code = 99
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char = p;code = 112
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char = i;code = 105
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char = (;code = 40
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char = .;code = 46
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char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 3;code = 51
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char = ;code = 32
char = f;code = 102
char = o;code = 111
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char = a;code = 97
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char = 2;code = 50
char = ,;code = 44
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char = 0;code = 48
char = 0;code = 48
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char = m;code = 109
char = i;code = 105
char = c;code = 99
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char = g;code = 103
char = /;code = 47
char = d;code = 100
char = a;code = 97
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char = i;code = 105
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char = e;code = 101
char = a;code = 97
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char = l;code = 108
char = u;code = 117
char = t;code = 116
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char = z;code = 122
char = e;code = 101
char = a;code = 97
char = x;code = 120
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char = t;code = 116
char = h;code = 104
char = i;code = 105
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char = i;code = 105
char = n;code = 110
char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = d;code = 100
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char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
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char = (;code = 40
char = 0;code = 48
char = .;code = 46
char = 9;code = 57
char = 7;code = 55
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 5;code = 53
char = );code = 41
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = a;code = 97
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char = 4;code = 52
char = ,;code = 44
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char = 0;code = 48
char = 0;code = 48
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
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char = g;code = 103
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char = d;code = 100
char = a;code = 97
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char = i;code = 105
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char = e;code = 101
char = a;code = 97
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char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = a;code = 97
char = s;code = 115
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char = o;code = 111
char = c;code = 99
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char = a;code = 97
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char = i;code = 105
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char = s;code = 115
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char = d;code = 100
char = i;code = 105
char = d;code = 100
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char = a;code = 97
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char = p;code = 112
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char = e;code = 101
char = c;code = 99
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char = a;code = 97
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = b;code = 98
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char = t;code = 116
char = u;code = 117
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char = p;code = 112
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char = v;code = 118
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char = u;code = 117
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char = s;code = 115
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char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
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char = e;code = 101
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char = u;code = 117
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char = e;code = 101
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char = g;code = 103
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char = A;code = 65
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char = n;code = 110
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char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = r;code = 114
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char = d;code = 100
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char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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result sql = Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive epithelial ovarian cancer. The primary data from 10 prospective cohort studies in North America and Europe were analyzed and then pooled. Carotenoid intakes were estimated from a validated food frequency questionnaire administered at baseline in each study. Study-specific relative risks (RR) were estimated using the Cox proportional hazards model and then combined using a random-effects model. Among 521,911 women, 2,012 cases of ovarian cancer occurred during a follow-up of 7-22 years across studies. The major carotenoids were not significantly associated with the risk of ovarian cancer. The pooled multivariate RRs (95% confidence intervals) were 1.00 (0.95-1.05) for a 600 microg/day increase in alpha-carotene intake, 0.96 (0.93-1.03) for a 2,500 microg/day increase in beta-carotene intake, 0.99 (0.97-1.02) for a 100 microg/day increase in beta-cryptoxanthin intake, 0.98 (0.94-1.03) for a 2,500 microg/day increase in lutein/zeaxanthin intake and 1.01 (0.97-1.05) for a 4,000 microg/day increase in lycopene intake. These associations did not appreciably differ by study (p-values, tests for between-studies heterogeneity >0.17). Also, the observed associations did not vary substantially by subgroups of the population or by histological type of ovarian cancer. These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer.

Publication: Int. J. Cancer 2006 Nov 1 ;119(9)::2148-54.
Publication Date: 2006 Nov 1
Study Author(s): Koushik, Anita;Hunter, David J;Spiegelman, Donna;Anderson, Kristin E;Buring, Julie E;Freudenheim, Jo L;Goldbohm, R Alexandra;Hankinson, Susan E;Larsson, Susanna C;Leitzmann, Michael;Marshall, James R;McCullough, Marjorie L;Miller, Anthony B;Rodriguez, Carmen;Rohan, Thomas E;Ross, Julie A;Schatzkin, Arthur;Schouten, Leo J;Willett, Walter C;Wolk, Alicja;Zhang, Shumin M;Smith-Warner, Stephanie A;
Institution: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Shortcut link to this study:
Carotenoids, found in fruits and vegetables, have the potential to protect against cancer because of their properties, including their functions as precursors to vitamin A and as antioxidants. We examined the associations between intakes of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin and lycopene and the risk of invasive epithelial ovarian cancer. The primary data from 10 prospective cohort studies in North America and Europe were analyzed and then pooled. Carotenoid intakes were estimated from a validated food frequency questionnaire administered at baseline in each study. Study-specific relative risks (RR) were estimated using the Cox proportional hazards model and then combined using a random-effects model. Among 521,911 women, 2,012 cases of ovarian cancer occurred during a follow-up of 7-22 years across studies. The major carotenoids were not significantly associated with the risk of ovarian cancer. The pooled multivariate RRs (95% confidence intervals) were 1.00 (0.95-1.05) for a 600 microg/day increase in alpha-carotene intake, 0.96 (0.93-1.03) for a 2,500 microg/day increase in beta-carotene intake, 0.99 (0.97-1.02) for a 100 microg/day increase in beta-cryptoxanthin intake, 0.98 (0.94-1.03) for a 2,500 microg/day increase in lutein/zeaxanthin intake and 1.01 (0.97-1.05) for a 4,000 microg/day increase in lycopene intake. These associations did not appreciably differ by study (p-values, tests for between-studies heterogeneity >0.17). Also, the observed associations did not vary substantially by subgroups of the population or by histological type of ovarian cancer. These results suggest that consumption of the major carotenoids during adulthood does not play a major role in the incidence of ovarian cancer.
PMID: 16823847

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