|
|
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result sql = Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.
Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.char = C;code = 67
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char = u;code = 117
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char = t;code = 116
char = ;code = 32
char = n;code = 110
char = u;code = 117
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char = l;code = 108
char = e;code = 101
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char = r;code = 114
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char = c;code = 99
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char = u;code = 117
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
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result sql = Cyclooxygenase-2 (COX-2) is antiapoptotic and is implicated in tumorigenesis. Recent reports, however, have also ascribed a proapoptotic action to inducible COX-2. We show here for the first time that a stilbene, resveratrol, induces nuclear accumulation of COX-2 protein in human breast cancer MCF-7 and MDA-MB-231 cell cultures. The induction of COX-2 accumulation by resveratrol is mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase 1/2)- and activator protein 1- dependent. Nuclear COX-2 in resveratrol-treated cells colocalizes with Ser(15)-phosphorylated p53 and with p300, a coactivator for p53-dependent gene expression. The interaction of COX-2, p53, and p300, as well as resveratrol-induced apoptosis, was inhibited by a MAPK activation inhibitor, PD98059. A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. We conclude that nuclear accumulation of COX-2 can be induced by resveratrol and that the COX has a novel intranuclear colocalization with Ser(15)-phosphorylated p53 and p300, which facilitates apoptosis in resveratrol-treated breast cancer cells.
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char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells.
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char = d;code = 100
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char = N;code = 78
char = u;code = 117
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char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = C;code = 67
char = O;code = 79
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char = 2;code = 50
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char = i;code = 105
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char = l;code = 108
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char = o;code = 111
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char = w;code = 119
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char = t;code = 116
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char = 0;code = 48
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char = r;code = 114
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char = o;code = 111
char = r;code = 114
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char = s;code = 115
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char = .;code = 46
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char = T;code = 84
char = h;code = 104
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char = i;code = 105
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char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = O;code = 79
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char = 2;code = 50
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char = e;code = 101
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char = R;code = 82
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char = k;code = 107
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char = c;code = 99
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char = f;code = 102
char = ;code = 32
char = C;code = 67
char = O;code = 79
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char = /;code = 47
char = >;code = 62
result sql = Cyclooxygenase-2 (COX-2) is antiapoptotic and is implicated in tumorigenesis. Recent reports, however, have also ascribed a proapoptotic action to inducible COX-2. We show here for the first time that a stilbene, resveratrol, induces nuclear accumulation of COX-2 protein in human breast cancer MCF-7 and MDA-MB-231 cell cultures. The induction of COX-2 accumulation by resveratrol is mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase 1/2)- and activator protein 1- dependent. Nuclear COX-2 in resveratrol-treated cells colocalizes with Ser(15)-phosphorylated p53 and with p300, a coactivator for p53-dependent gene expression. The interaction of COX-2, p53, and p300, as well as resveratrol-induced apoptosis, was inhibited by a MAPK activation inhibitor, PD98059. A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. We conclude that nuclear accumulation of COX-2 can be induced by resveratrol and that the COX has a novel intranuclear colocalization with Ser(15)-phosphorylated p53 and p300, which facilitates apoptosis in resveratrol-treated breast cancer cells.
Publication: Mol. Cancer Ther. 2006 Aug ;5(8)::2034-42.
Publication Date: 2006 Aug
Study Author(s): Tang, Heng-Yuan;Shih, Ai;Cao, H James;Davis, Faith B;Davis, Paul J;Lin, Hung-Yun;
Institution: Research Service, Stratton Veterns Affairs Medical Center, New York State Department of Health, Albany, New York, USA.
Shortcut link to this study:
Publication Date: 2006 Aug
Study Author(s): Tang, Heng-Yuan;Shih, Ai;Cao, H James;Davis, Faith B;Davis, Paul J;Lin, Hung-Yun;
Institution: Research Service, Stratton Veterns Affairs Medical Center, New York State Department of Health, Albany, New York, USA.
Shortcut link to this study:
Cyclooxygenase-2 (COX-2) is antiapoptotic and is implicated in tumorigenesis. Recent reports, however, have also ascribed a proapoptotic action to inducible COX-2. We show here for the first time that a stilbene, resveratrol, induces nuclear accumulation of COX-2 protein in human breast cancer MCF-7 and MDA-MB-231 cell cultures. The induction of COX-2 accumulation by resveratrol is mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase 1/2)- and activator protein 1- dependent. Nuclear COX-2 in resveratrol-treated cells colocalizes with Ser(15)-phosphorylated p53 and with p300, a coactivator for p53-dependent gene expression. The interaction of COX-2, p53, and p300, as well as resveratrol-induced apoptosis, was inhibited by a MAPK activation inhibitor, PD98059. A specific inhibitor of COX-2, NS398, and small interfering RNA knockdown of COX-2 were associated with reduced p53 phosphorylation and consequent decrease in p53-dependent apoptosis in resveratrol-treated cells. We conclude that nuclear accumulation of COX-2 can be induced by resveratrol and that the COX has a novel intranuclear colocalization with Ser(15)-phosphorylated p53 and p300, which facilitates apoptosis in resveratrol-treated breast cancer cells.
PMID: 16928824
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