char = S;code = 83
char = l;code = 108
char = e;code = 101
char = e;code = 101
char = p;code = 112
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char = r;code = 114
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char = l;code = 108
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char = ;code = 32
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char = ;code = 32
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = n;code = 110
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char = u;code = 117
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char = l;code = 108
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char = l;code = 108
char = e;code = 101
char = p;code = 112
char = s;code = 115
char = y;code = 121
char = .;code = 46
result sql = Sleep-related minor motor events in nocturnal frontal lobe epilepsy.
Sleep-related minor motor events in nocturnal frontal lobe epilepsy.
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char = P;code = 80
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char = P;code = 80
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char = b;code = 98
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char = N;code = 78
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char = c;code = 99
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char = u;code = 117
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char = a;code = 97
char = l;code = 108
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char = f;code = 102
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char = ;code = 32
char = l;code = 108
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char = (;code = 40
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char = L;code = 76
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char = );code = 41
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char = a;code = 97
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char = z;code = 122
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char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = s;code = 115
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char = e;code = 101
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char = c;code = 99
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char = n;code = 110
char = g;code = 103
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char = c;code = 99
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char = m;code = 109
char = p;code = 112
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char = e;code = 101
char = x;code = 120
char = i;code = 105
char = t;code = 116
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char = ,;code = 44
char = ;code = 32
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char = g;code = 103
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
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char = o;code = 111
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char = e;code = 101
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char = ;code = 32
char = (;code = 40
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char = n;code = 110
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char = o;code = 111
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char = ;code = 32
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char = e;code = 101
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char = M;code = 77
char = E;code = 69
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char = M;code = 77
char = M;code = 77
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char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = e;code = 101
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char = y;code = 121
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char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
char = r;code = 114
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char = ;code = 32
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char = e;code = 101
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char = r;code = 114
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char = m;code = 109
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char = u;code = 117
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char = e;code = 101
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char = M;code = 77
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char = S;code = 83
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char = e;code = 101
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char = e;code = 101
char = n;code = 110
char = o;code = 111
char = l;code = 108
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char = g;code = 103
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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result sql = PURPOSE : Nocturnal frontal lobe epilepsy (NFLE) is characterized by a wide spectrum of sleep-related motor manifestations of increasing complexity, ranging from major episodes to brief motor events (minor motor events, MMEs). NFLE patients may exhibit a large quantity of MMEs in the form of short-lasting stereotyped movements. Whereas major episodes are considered epileptiform manifestations, it remains unclear whether the MMEs are related to epileptiform discharges (EDs).

METHODS : To study the relation between EDs and the occurrence of MMEs, we report a detailed neurophysiolgical evaluation in NFLE subjects explored by using implanted electrodes.

RESULTS : The median value of ED-related movements was 71.8%. Motor expression in relation to epileptiform discharge was surprisingly variable; no peculiar expression of MMEs could be attributed to the presence of EDs.

CONCLUSIONS : Our data suggest that ED-associated MMEs are extremely polymorphous, and no univocal relation to EDs can be identified. We hypothesize that MMEs are not a direct effect of epileptiform discharge (i.e., not epileptic in origin), but the result of aspecific disinhibition of innate motor patterns. We warn clinicians that the epileptic nature of minimal motor phenomena in NFLE cannot be established on the clinical phenomenology of the event.

Publication: Epilepsia 2007 Feb ;48(2)::335-41.
Publication Date: 2007 Feb
Study Author(s): Terzaghi, Michele;Sartori, Ivana;Mai, Roberto;Tassi, Laura;Francione, Stefano;Cardinale, Francesco;Castana, Laura;Cossu, Massimo;LoRusso, Giorgio;Manni, Raffaele;Nobili, Lino;
Institution: Sleep Medicine and Epilepsy Unit, IRCCS C. Mondino Institute of Neurology Foundation, Pavia, Italy. [email protected]
Shortcut link to this study:
PURPOSE : Nocturnal frontal lobe epilepsy (NFLE) is characterized by a wide spectrum of sleep-related motor manifestations of increasing complexity, ranging from major episodes to brief motor events (minor motor events, MMEs). NFLE patients may exhibit a large quantity of MMEs in the form of short-lasting stereotyped movements. Whereas major episodes are considered epileptiform manifestations, it remains unclear whether the MMEs are related to epileptiform discharges (EDs).

METHODS : To study the relation between EDs and the occurrence of MMEs, we report a detailed neurophysiolgical evaluation in NFLE subjects explored by using implanted electrodes.

RESULTS : The median value of ED-related movements was 71.8%. Motor expression in relation to epileptiform discharge was surprisingly variable; no peculiar expression of MMEs could be attributed to the presence of EDs.

CONCLUSIONS : Our data suggest that ED-associated MMEs are extremely polymorphous, and no univocal relation to EDs can be identified. We hypothesize that MMEs are not a direct effect of epileptiform discharge (i.e., not epileptic in origin), but the result of aspecific disinhibition of innate motor patterns. We warn clinicians that the epileptic nature of minimal motor phenomena in NFLE cannot be established on the clinical phenomenology of the event.
PMID: 17295628

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