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char = p;code = 112
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char = e;code = 101
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char = p;code = 112
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char = s;code = 115
char = e;code = 101
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char = l;code = 108
char = i;code = 105
char = p;code = 112
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char = ;code = 32
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char = t;code = 116
char = i;code = 105
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char = n;code = 110
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char = ;code = 32
char = r;code = 114
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char = d;code = 100
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char = e;code = 101
char = s;code = 115
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char = h;code = 104
char = y;code = 121
char = p;code = 112
char = o;code = 111
char = x;code = 120
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char = c;code = 99
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char = i;code = 105
char = s;code = 115
char = c;code = 99
char = h;code = 104
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char = m;code = 109
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char = c;code = 99
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char = b;code = 98
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char = a;code = 97
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = j;code = 106
char = u;code = 117
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char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = n;code = 110
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char = a;code = 97
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Grape seed extract given three hours after injury suppresses lipid peroxidation and reduces hypoxic-ischemic brain injury in neonatal rats.
Grape seed extract given three hours after injury suppresses lipid peroxidation and reduces hypoxic-ischemic brain injury in neonatal rats.
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char = G;code = 71
char = F;code = 70
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char = l;code = 108
char = p;code = 112
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char = d;code = 100
char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = -;code = 45
char = i;code = 105
char = n;code = 110
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char = p;code = 112
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char = o;code = 111
char = t;code = 116
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char = n;code = 110
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char = h;code = 104
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char = i;code = 105
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char = ;code = 32
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char = e;code = 101
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char = i;code = 105
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char = i;code = 105
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char = i;code = 105
char = d;code = 100
char = a;code = 97
char = t;code = 116
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char = o;code = 111
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result sql = We have reported that pretreatment with grape seed extract (GSE), a potent antioxidant, is neuroprotective. This study examined whether treatment after injury with GSE is protective. Seven-day-old rat pups had the right carotid artery ligated, and then 2.5 h of 8% oxygen. GSE (50 mg/kg) or vehicle was administered by i.p. initial injection at 5 min to 5 h after reoxygenation, with an additional three doses within 26 h after injury. Brain damage was evaluated by weight deficit of the right hemisphere at 22 d after hypoxia. Treatment at 3 h after reoxygenation reduced brain weight loss from 21.0 +/- 3.3% in vehicle-treated pups (n = 31) to 11.4 +/- 2.8% in treated pups (n = 31, p < 0.05). GSE lowered body temperature, but reduced brain injury even when body temperature was controlled. GSE reduced neurofunctional abnormalities caused by the hypoxia-ischemia (HI). GSE reduced a HI induced increase in 8-isoprostaglandin F2alpha (8-isoPGF2alpha) and reduced an HI-induced increase in the proapoptotic protein c-jun in the brain cortex. GSE up to 3 h after reoxygenation reduces brain injury in rat pups, probably by suppressing lipid peroxidation and the proapoptotic protein c-jun.

Publication: Pediatr. Res. 2007 Mar ;61(3)::295-300.
Publication Date: 2007 Mar
Study Author(s): Feng, Yangzheng;Liu, Yi-Ming;Leblanc, Michael H;Bhatt, Abhay J;Rhodes, Philip G;
Institution: Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. yfeng@ped.umsmed.edu
Shortcut link to this study:
We have reported that pretreatment with grape seed extract (GSE), a potent antioxidant, is neuroprotective. This study examined whether treatment after injury with GSE is protective. Seven-day-old rat pups had the right carotid artery ligated, and then 2.5 h of 8% oxygen. GSE (50 mg/kg) or vehicle was administered by i.p. initial injection at 5 min to 5 h after reoxygenation, with an additional three doses within 26 h after injury. Brain damage was evaluated by weight deficit of the right hemisphere at 22 d after hypoxia. Treatment at 3 h after reoxygenation reduced brain weight loss from 21.0 +/- 3.3% in vehicle-treated pups (n = 31) to 11.4 +/- 2.8% in treated pups (n = 31, p < 0.05). GSE lowered body temperature, but reduced brain injury even when body temperature was controlled. GSE reduced neurofunctional abnormalities caused by the hypoxia-ischemia (HI). GSE reduced a HI induced increase in 8-isoprostaglandin F2alpha (8-isoPGF2alpha) and reduced an HI-induced increase in the proapoptotic protein c-jun in the brain cortex. GSE up to 3 h after reoxygenation reduces brain injury in rat pups, probably by suppressing lipid peroxidation and the proapoptotic protein c-jun.
PMID: 17314686

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