char = S;code = 83 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = -;code = 45 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = p;code = 112 char = s;code = 115 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = A;code = 65 char = /;code = 47 char = J;code = 74 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = e;code = 101 char = .;code = 46 result sql = Sleep-related epilepsy in the A/J mouse.
Sleep-related epilepsy in the A/J mouse.char = <;code = 60 char = b;code = 98 char = >;code = 62 char = R;code = 82 char = A;code = 65 char = T;code = 84 char = I;code = 73 char = O;code = 79 char = N;code = 78 char = A;code = 65 char = L;code = 76 char = E;code = 69 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = E;code = 69 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = i;code = 105 char = z;code = 122 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = u;code = 117 char = n;code = 110 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = m;code = 109 char = o;code = 111 char = n;code = 110 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = p;code = 112 char = s;code = 115 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = v;code = 118 char = i;code = 105 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = b;code = 98 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = s;code = 115 char = p;code = 112 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = p;code = 112 char = i;code = 105 char = k;code = 107 char = e;code = 101 char = -;code = 45 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = -;code = 45 char = w;code = 119 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = A;code = 65 char = /;code = 47 char = J;code = 74 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = A;code = 65 char = /;code = 47 char = J;code = 74 char = ;code = 32 char = J;code = 74 char = A;code = 65 char = X;code = 88 char = );code = 41 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = J;code = 74 char = a;code = 97 char = c;code = 99 char = k;code = 107 char = s;code = 115 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = L;code = 76 char = a;code = 97 char = b;code = 98 char = o;code = 111 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = (;code = 40 char = B;code = 66 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = H;code = 72 char = a;code = 97 char = r;code = 114 char = b;code = 98 char = o;code = 111 char = r;code = 114 char = ,;code = 44 char = ;code = 32 char = M;code = 77 char = E;code = 69 char = );code = 41 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = s;code = 115 char = c;code = 99 char = r;code = 114 char = i;code = 105 char = p;code = 112 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = p;code = 112 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = M;code = 77 char = E;code = 69 char = T;code = 84 char = H;code = 72 char = O;code = 79 char = D;code = 68 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = M;code = 77 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = A;code = 65 char = /;code = 47 char = J;code = 74 char = ,;code = 44 char = ;code = 32 char = C;code = 67 char = 5;code = 53 char = 7;code = 55 char = B;code = 66 char = I;code = 73 char = /;code = 47 char = 6;code = 54 char = J;code = 74 char = ;code = 32 char = (;code = 40 char = B;code = 66 char = 6;code = 54 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = o;code = 111 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = b;code = 98 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = u;code = 117 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = r;code = 114 char = d;code = 100 char = ;code = 32 char = E;code = 69 char = E;code = 69 char = G;code = 71 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = E;code = 69 char = M;code = 77 char = G;code = 71 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = -;code = 45 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = p;code = 112 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = d;code = 100 char = r;code = 114 char = u;code = 117 char = g;code = 103 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = m;code = 109 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = k;code = 107 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = y;code = 121 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = b;code = 98 char = -;code = 45 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = o;code = 111 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = g;code = 103 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = R;code = 82 char = E;code = 69 char = S;code = 83 char = U;code = 85 char = L;code = 76 char = T;code = 84 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = S;code = 83 char = p;code = 112 char = i;code = 105 char = k;code = 107 char = e;code = 101 char = -;code = 45 char = d;code = 100 char = i;code = 105 char = s;code = 115 char = c;code = 99 char = h;code = 104 char = a;code = 97 char = r;code = 114 char = g;code = 103 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 1;code = 49 char = 2;code = 50 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = );code = 41 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = 9;code = 57 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = r;code = 114 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 1;code = 49 char = 7;code = 55 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = e;code = 101 char = q;code = 113 char = u;code = 117 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 6;code = 54 char = .;code = 46 char = 4;code = 52 char = 1;code = 49 char = ;code = 32 char = H;code = 72 char = z;code = 122 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 6;code = 54 char = 3;code = 51 char = 4;code = 52 char = .;code = 46 char = 8;code = 56 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = V;code = 86 char = .;code = 46 char = ;code = 32 char = C;code = 67 char = l;code = 108 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = b;code = 98 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = %;code = 37 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = E;code = 69 char = p;code = 112 char = i;code = 105 char = s;code = 115 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = (;code = 40 char = >;code = 62 char = ;code = 32 char = 7;code = 55 char = 5;code = 53 char = %;code = 37 char = );code = 41 char = ;code = 32 char = e;code = 101 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = -;code = 45 char = w;code = 119 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = -;code = 45 char = w;code = 119 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = .;code = 46 char = ;code = 32 char = E;code = 69 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = a;code = 97 char = d;code = 100 char = o;code = 111 char = x;code = 120 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = .;code = 46 char = ;code = 32 char = C;code = 67 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = h;code = 104 char = i;code = 105 char = c;code = 99 char = l;code = 108 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = t;code = 116 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = a;code = 97 char = d;code = 100 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = e;code = 101 char = t;code = 116 char = h;code = 104 char = o;code = 111 char = s;code = 115 char = u;code = 117 char = x;code = 120 char = i;code = 105 char = m;code = 109 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = 5;code = 53 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = g;code = 103 char = /;code = 47 char = k;code = 107 char = g;code = 103 char = );code = 41 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = a;code = 97 char = z;code = 122 char = e;code = 101 char = p;code = 112 char = a;code = 97 char = m;code = 109 char = ;code = 32 char = (;code = 40 char = 5;code = 53 char = ;code = 32 char = m;code = 109 char = g;code = 103 char = /;code = 47 char = k;code = 107 char = g;code = 103 char = );code = 41 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = h;code = 104 char = i;code = 105 char = b;code = 98 char = i;code = 105 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = e;code = 101 char = l;code = 108 char = i;code = 105 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = i;code = 105 char = z;code = 122 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = s;code = 115 char = t;code = 116 char = ,;code = 44 char = ;code = 32 char = s;code = 115 char = p;code = 112 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = p;code = 112 char = i;code = 105 char = k;code = 107 char = e;code = 101 char = -;code = 45 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = -;code = 45 char = w;code = 119 char = a;code = 97 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = b;code = 98 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = A;code = 65 char = /;code = 47 char = J;code = 74 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = H;code = 72 char = a;code = 97 char = r;code = 114 char = l;code = 108 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = N;code = 78 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = L;code = 76 char = a;code = 97 char = b;code = 98 char = o;code = 111 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = I;code = 73 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = a;code = 97 char = n;code = 110 char = a;code = 97 char = p;code = 112 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = d;code = 100 char = );code = 41 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = B;code = 66 char = 6;code = 54 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = J;code = 74 char = a;code = 97 char = c;code = 99 char = k;code = 107 char = s;code = 115 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = L;code = 76 char = a;code = 97 char = b;code = 98 char = o;code = 111 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = A;code = 65 char = /;code = 47 char = J;code = 74 char = ;code = 32 char = J;code = 74 char = A;code = 65 char = X;code = 88 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = B;code = 66 char = 6;code = 54 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = i;code = 105 char = r;code = 114 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = g;code = 103 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = b;code = 98 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = 2;code = 50 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = -;code = 45 char = s;code = 115 char = u;code = 117 char = b;code = 98 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = B;code = 66 char = 6;code = 54 char = .;code = 46 char = A;code = 65 char = 4;code = 52 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = B;code = 66 char = 6;code = 54 char = .;code = 46 char = A;code = 65 char = 7;code = 55 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = -;code = 45 char = s;code = 115 char = u;code = 117 char = b;code = 98 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = 1;code = 49 char = 1;code = 49 char = 3;code = 51 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = k;code = 107 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = b;code = 98 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = i;code = 105 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = ;code = 32 char = 4;code = 52 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 char = <;code = 60 char = b;code = 98 char = >;code = 62 char = C;code = 67 char = O;code = 79 char = N;code = 78 char = C;code = 67 char = L;code = 76 char = U;code = 85 char = S;code = 83 char = I;code = 73 char = O;code = 79 char = N;code = 78 char = S;code = 83 char = ;code = 32 char = :;code = 58 char = ;code = 32 char = <;code = 60 char = /;code = 47 char = b;code = 98 char = >;code = 62 char = T;code = 84 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = s;code = 115 char = l;code = 108 char = e;code = 101 char = e;code = 101 char = p;code = 112 char = -;code = 45 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = l;code = 108 char = e;code = 101 char = p;code = 112 char = s;code = 115 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = h;code = 104 char = e;code = 101 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = y;code = 121 char = p;code = 112 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = h;code = 104 char = i;code = 105 char = b;code = 98 char = i;code = 105 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = g;code = 103 char = o;code = 111 char = g;code = 103 char = e;code = 101 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = t;code = 116 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = e;code = 101 char = l;code = 108 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = .;code = 46 result sql = RATIONALE : Evident seizures during sleep are common in clinical practice but are uncommonly considered in animal models of epilepsy. A previous observation of spontaneous spike-and-wave activity during sleep in several A/J mice (A/J JAX) from Jackson Laboratory (Bar Harbor, ME) prompted this description of the inheritance of epileptic activity.METHODS : Mice from A/J, C57BI/6J (B6), and chromosomal substitutions strains were instrumented to record EEG and EMG activity over time without and with anti-epileptic drugs. Intercrosses were performed using linkage analysis to localize sub-chromosomal regions.RESULTS : Spike-discharge patterns (n = 12 mice) were of average duration of 1.9 seconds at a rate per hour of 17, with an intrinsic frequency of 6.41 Hz and an amplitude of 634.8 microV. Clonic movements were observed in < 10% of the episodes. Episodes were expressed (> 75%) either in slow-wave sleep or in transitions to and from slow-wave sleep. Events were rare in paradoxical sleep. Compared with vehicle, intraperitoneal administration of ethosuximide (150 mg/kg) or diazepam (5 mg/kg) inhibited or eliminated seizure activity, respectively. In contrast, spontaneous spike-and-wave activity was not observed in A/J mice from Harlan National Laboratories (Indianapolis, Ind) or in B6 mice from Jackson Laboratory. In an intercross between A/J JAX and B6 mice, the trait was not present in the first generation. The trait was observed in 2 chromosome-substitution strains, B6.A4 and B6.A7. In the intercross second generation of these chromosome-substitution strains (n = 113), significant linkage was observed to loci on chromosome 4.CONCLUSIONS : This is a sleep-related epilepsy phenotype that exhibits an oligogenic pattern of allelic inheritance.
Publication: Sleep 2007 Feb ;30(2)::169-76.
Publication Date: 2007 Feb
Study Author(s): Strohl, Kingman P;Gallaugher, Laura;Lynn, Audrey;Friedman, Lee;Hill, Annie;Singer, Jonathan B;Lander, Eric S;Nadeau, Joseph;
Institution: Department of Medicine, Case Western Reserve University, Cleveland OH, USA.
[email protected]
Shortcut link to this study:
RATIONALE : Evident seizures during sleep are common in clinical practice but are uncommonly considered in animal models of epilepsy. A previous observation of spontaneous spike-and-wave activity during sleep in several A/J mice (A/J JAX) from Jackson Laboratory (Bar Harbor, ME) prompted this description of the inheritance of epileptic activity.METHODS : Mice from A/J, C57BI/6J (B6), and chromosomal substitutions strains were instrumented to record EEG and EMG activity over time without and with anti-epileptic drugs. Intercrosses were performed using linkage analysis to localize sub-chromosomal regions.RESULTS : Spike-discharge patterns (n = 12 mice) were of average duration of 1.9 seconds at a rate per hour of 17, with an intrinsic frequency of 6.41 Hz and an amplitude of 634.8 microV. Clonic movements were observed in < 10% of the episodes. Episodes were expressed (> 75%) either in slow-wave sleep or in transitions to and from slow-wave sleep. Events were rare in paradoxical sleep. Compared with vehicle, intraperitoneal administration of ethosuximide (150 mg/kg) or diazepam (5 mg/kg) inhibited or eliminated seizure activity, respectively. In contrast, spontaneous spike-and-wave activity was not observed in A/J mice from Harlan National Laboratories (Indianapolis, Ind) or in B6 mice from Jackson Laboratory. In an intercross between A/J JAX and B6 mice, the trait was not present in the first generation. The trait was observed in 2 chromosome-substitution strains, B6.A4 and B6.A7. In the intercross second generation of these chromosome-substitution strains (n = 113), significant linkage was observed to loci on chromosome 4.CONCLUSIONS : This is a sleep-related epilepsy phenotype that exhibits an oligogenic pattern of allelic inheritance.
PMID: 17326542