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char = .;code = 46
result sql = [Effect of extract of ginkgo biloba leaves on the precondition of liver graft in rat liver transplantation].
[Effect of extract of ginkgo biloba leaves on the precondition of liver graft in rat liver transplantation].
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = l;code = 108
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char = c;code = 99
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char = o;code = 111
char = r;code = 114
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char = ;code = 32
char = t;code = 116
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char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
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result sql = OBJECTIVE : To explore the effect of extract of ginkgo biloba leaves on the precondition of liver graft in rat liver transplantation.

METHODS : Male Sprague-Dawley rats were used as donors and recipients of orthotopic liver transplantation (OLT), and were randomly divided into extract of ginkgo biloba leaves group (Egb), NS control group (NS), and sham operation group (SO) according to whether the extract of ginkgo biloba leaves was injected by the venous (40 mg/kg) 1 h before the liver grafts harvesting. The rats were killed at 2 h, 6 h, and 24 h after the ischemia/reperfusion. The serum concentrations of ALT and AST were determined and the liver tissue were sampled to observe the expression of TNF-alpha and IL-1.

RESULTS : After the ischemia/reperfusion the serum concentration of ALT and AST and expressions of TNF-alpha and IL-1 in the hepatic tissue in the NS group significantly increased (p<0.01), and the hepatocytic morphologic change was obvious compared with the SO group. The treatment of ginkgo biloba extract significantly decreased the serum concentration of ALT and AST and the expressions of TNF-alpha and IL-1 in the hepatic tissue in EGb group compared with the NS group (p<0.01), and relieved the hepatocyte swelling and necrosis.

CONCLUSION : Ginkgo bilobA extract may decrease the release of TNF-alpha and IL-1 by inhibiting activation of kuffer cells and regulate the cell factors to protect the live.

Publication: Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007 Feb ;32(1)::54-8.
Publication Date: 2007 Feb
Study Author(s): Zhou, Jie-Bin;Yang, Xue-Kang;Ye, Qi-Fa;Ming, Ying-Zi;Xia, Zong-Jiang;
Institution: Institute of Organ Transplantation, Third Xiangya Hospital, Central South University, Department of General Surgery, Changsha Central Hospital, Changsha 410013, China. [email protected]
Shortcut link to this study:
OBJECTIVE : To explore the effect of extract of ginkgo biloba leaves on the precondition of liver graft in rat liver transplantation.

METHODS : Male Sprague-Dawley rats were used as donors and recipients of orthotopic liver transplantation (OLT), and were randomly divided into extract of ginkgo biloba leaves group (Egb), NS control group (NS), and sham operation group (SO) according to whether the extract of ginkgo biloba leaves was injected by the venous (40 mg/kg) 1 h before the liver grafts harvesting. The rats were killed at 2 h, 6 h, and 24 h after the ischemia/reperfusion. The serum concentrations of ALT and AST were determined and the liver tissue were sampled to observe the expression of TNF-alpha and IL-1.

RESULTS : After the ischemia/reperfusion the serum concentration of ALT and AST and expressions of TNF-alpha and IL-1 in the hepatic tissue in the NS group significantly increased (p<0.01), and the hepatocytic morphologic change was obvious compared with the SO group. The treatment of ginkgo biloba extract significantly decreased the serum concentration of ALT and AST and the expressions of TNF-alpha and IL-1 in the hepatic tissue in EGb group compared with the NS group (p<0.01), and relieved the hepatocyte swelling and necrosis.

CONCLUSION : Ginkgo bilobA extract may decrease the release of TNF-alpha and IL-1 by inhibiting activation of kuffer cells and regulate the cell factors to protect the live.
PMID: 17344587

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