|
|
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result sql = Selective vitamin D receptor modulators and their effects on colorectal tumor growth.
Selective vitamin D receptor modulators and their effects on colorectal tumor growth.char = T;code = 84
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result sql = The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is an endocrine hormone whose classic role is the maintenance of calcium homeostasis. It is well documented that 1,25(OH)(2)D(3) also has anti-tumor effects on a number of cancers and cancer cell lines including breast, colorectal, gastric, liver, ovarian, prostate, and non-melanoma skin cancers. Included in the anti-tumor activities of 1,25(OH)(2)D(3) are its ability to cause antiproliferation, prodifferentation and decrease angiogenesis. Furthermore, through regulation of the plaminogen activator (PA) system and a class of proteolytic enzymes called matrix metalloproteinases (MMPs), 1,25(OH)(2)D(3) reduces the invasive spread of tumor cells. Because of the calcemic limitations of using 1,25(OH)(2)D(3) as a therapy, we have tested the effects of a novel Gemini vitamin D analogue, Deuterated Gemini (DG), on mouse colorectal cancer. We demonstrated that DG is more potent in reducing tumor volume and mass, compared to control and 1,25(OH)(2)D(3). DG significantly prevented (100% reduction, p<0.05) the invasive spread of colorectal tumor cells into the surrounding muscle, and had no effect on serum calcium levels. Thus, DG acts as a selective vitamin D receptor modulator (SVDRM) by enhancing select anti-tumor characteristic 1,25(OH)(2)D(3) activities, without inducing hypercalcemia. Thus, DG shows promise in the development of colorectal cancer therapies.
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result sql = Selective vitamin D receptor modulators and their effects on colorectal tumor growth.
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char = (;code = 40
char = 2;code = 50
char = );code = 41
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = r;code = 114
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char = c;code = 99
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char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = i;code = 105
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char = c;code = 99
char = l;code = 108
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char = a;code = 97
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char = t;code = 116
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char = o;code = 111
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char = r;code = 114
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = ;code = 32
char = n;code = 110
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char = n;code = 110
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char = e;code = 101
char = l;code = 108
char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = s;code = 115
char = k;code = 107
char = i;code = 105
char = n;code = 110
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = c;code = 99
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char = u;code = 117
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = i;code = 105
char = -;code = 45
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
char = ,;code = 44
char = 2;code = 50
char = 5;code = 53
char = (;code = 40
char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
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char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = t;code = 116
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char = c;code = 99
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char = s;code = 115
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = p;code = 112
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = d;code = 100
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
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char = t;code = 116
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = d;code = 100
char = ;code = 32
char = d;code = 100
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char = a;code = 97
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char = s;code = 115
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char = s;code = 115
char = .;code = 46
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char = F;code = 70
char = u;code = 117
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
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char = g;code = 103
char = h;code = 104
char = ;code = 32
char = r;code = 114
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char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = l;code = 108
char = a;code = 97
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char = A;code = 65
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char = M;code = 77
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char = ,;code = 44
char = ;code = 32
char = 1;code = 49
char = ,;code = 44
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char = O;code = 79
char = H;code = 72
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char = D;code = 68
char = (;code = 40
char = 3;code = 51
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char = a;code = 97
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char = m;code = 109
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char = r;code = 114
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char = c;code = 99
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char = B;code = 66
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char = c;code = 99
char = a;code = 97
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char = f;code = 102
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char = c;code = 99
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char = c;code = 99
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char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = u;code = 117
char = s;code = 115
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char = n;code = 110
char = g;code = 103
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char = 1;code = 49
char = ,;code = 44
char = 2;code = 50
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char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = D;code = 68
char = (;code = 40
char = 3;code = 51
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = w;code = 119
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char = a;code = 97
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = 1;code = 49
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char = O;code = 79
char = H;code = 72
char = );code = 41
char = (;code = 40
char = 2;code = 50
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char = D;code = 68
char = (;code = 40
char = 3;code = 51
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char = .;code = 46
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char = G;code = 71
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char = i;code = 105
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char = p;code = 112
char = <;code = 60
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char = s;code = 115
char = p;code = 112
char = r;code = 114
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char = a;code = 97
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result sql = The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is an endocrine hormone whose classic role is the maintenance of calcium homeostasis. It is well documented that 1,25(OH)(2)D(3) also has anti-tumor effects on a number of cancers and cancer cell lines including breast, colorectal, gastric, liver, ovarian, prostate, and non-melanoma skin cancers. Included in the anti-tumor activities of 1,25(OH)(2)D(3) are its ability to cause antiproliferation, prodifferentation and decrease angiogenesis. Furthermore, through regulation of the plaminogen activator (PA) system and a class of proteolytic enzymes called matrix metalloproteinases (MMPs), 1,25(OH)(2)D(3) reduces the invasive spread of tumor cells. Because of the calcemic limitations of using 1,25(OH)(2)D(3) as a therapy, we have tested the effects of a novel Gemini vitamin D analogue, Deuterated Gemini (DG), on mouse colorectal cancer. We demonstrated that DG is more potent in reducing tumor volume and mass, compared to control and 1,25(OH)(2)D(3). DG significantly prevented (100% reduction, p<0.05) the invasive spread of colorectal tumor cells into the surrounding muscle, and had no effect on serum calcium levels. Thus, DG acts as a selective vitamin D receptor modulator (SVDRM) by enhancing select anti-tumor characteristic 1,25(OH)(2)D(3) activities, without inducing hypercalcemia. Thus, DG shows promise in the development of colorectal cancer therapies.
Publication: J. Steroid Biochem. Mol. Biol. 2007 Mar ;103(3-5)::757-62.
Publication Date: 2007 Mar
Study Author(s): Spina, C S;Ton, L;Yao, M;Maehr, H;Wolfe, M M;Uskokovic, M;Adorini, L;Holick, M F;
Institution: Vitamin D, Skin and Bone Research Laboratories, Endocrine Section, Department of Medicine, Physiology and Biophysics, Boston University Medical Center, 715 Albany Street, M-1013, Boston, MA 02118, USA. [email protected]
Shortcut link to this study:
Publication Date: 2007 Mar
Study Author(s): Spina, C S;Ton, L;Yao, M;Maehr, H;Wolfe, M M;Uskokovic, M;Adorini, L;Holick, M F;
Institution: Vitamin D, Skin and Bone Research Laboratories, Endocrine Section, Department of Medicine, Physiology and Biophysics, Boston University Medical Center, 715 Albany Street, M-1013, Boston, MA 02118, USA. [email protected]
Shortcut link to this study:
The active form of vitamin D, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is an endocrine hormone whose classic role is the maintenance of calcium homeostasis. It is well documented that 1,25(OH)(2)D(3) also has anti-tumor effects on a number of cancers and cancer cell lines including breast, colorectal, gastric, liver, ovarian, prostate, and non-melanoma skin cancers. Included in the anti-tumor activities of 1,25(OH)(2)D(3) are its ability to cause antiproliferation, prodifferentation and decrease angiogenesis. Furthermore, through regulation of the plaminogen activator (PA) system and a class of proteolytic enzymes called matrix metalloproteinases (MMPs), 1,25(OH)(2)D(3) reduces the invasive spread of tumor cells. Because of the calcemic limitations of using 1,25(OH)(2)D(3) as a therapy, we have tested the effects of a novel Gemini vitamin D analogue, Deuterated Gemini (DG), on mouse colorectal cancer. We demonstrated that DG is more potent in reducing tumor volume and mass, compared to control and 1,25(OH)(2)D(3). DG significantly prevented (100% reduction, p<0.05) the invasive spread of colorectal tumor cells into the surrounding muscle, and had no effect on serum calcium levels. Thus, DG acts as a selective vitamin D receptor modulator (SVDRM) by enhancing select anti-tumor characteristic 1,25(OH)(2)D(3) activities, without inducing hypercalcemia. Thus, DG shows promise in the development of colorectal cancer therapies.
PMID: 17368190
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