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result sql = The influence of di-acetylation of the hydroxyl groups on the anti-tumor-proliferation activity of lutein and zeaxanthin.
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char = a;code = 97
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char = u;code = 117
char = t;code = 116
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char = a;code = 97
char = n;code = 110
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char = d;code = 100
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char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
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char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
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char = t;code = 116
char = l;code = 108
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char = ;code = 32
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char = ;code = 32
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char = a;code = 97
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char = ;code = 32
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char = f;code = 102
char = t;code = 116
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char = ;code = 32
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char = ;code = 32
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char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = s;code = 115
char = ;code = 32
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char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
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char = t;code = 116
char = u;code = 117
char = m;code = 109
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char = c;code = 99
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
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char = ;code = 32
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char = t;code = 116
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char = d;code = 100
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char = z;code = 122
char = e;code = 101
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char = t;code = 116
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Lutein and zeaxanthin have various activities such as anti-age-related macular degeneration, anticataract, anticancer and cardiovascular diseases risk lowering, etc.; however, few studies have been reported on the role of free hydroxyl groups in the antitumor effects of lutein and zeaxanthin. The structure-activity relationship (SAR) of lutein and zeaxanthin di-acetylation derivatives has been investigated. The lutein and zeaxanthin were purified from corn protein residues and structurally modified by di-acetylation, which was characterized with UV/visible and HPLC/MS spectroscopy. The anti-proliferative effects of di-acetylated lutein or zeaxanthin on the human mouth epithelial cancer line KB cell were compared with controls of their original counterparts. Results showed that the anti-tumor activities of the di-acetylation of lutein and di-acetylation of zeaxanthin decreased significantly (p<0.05) at 50 micromol/L. Also the related IC50 dose was increased after di-acetylation. It was suggested that the hydroxyl groups contribute to the anti-tumor activity of lutein and zeaxanthin.
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char = e;code = 101
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char = d;code = 100
char = i;code = 105
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char = e;code = 101
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char = y;code = 121
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = n;code = 110
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char = h;code = 104
char = e;code = 101
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char = h;code = 104
char = y;code = 121
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char = o;code = 111
char = x;code = 120
char = y;code = 121
char = l;code = 108
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char = o;code = 111
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char = o;code = 111
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = z;code = 122
char = e;code = 101
char = a;code = 97
char = x;code = 120
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = n;code = 110
char = .;code = 46
result sql = The influence of di-acetylation of the hydroxyl groups on the anti-tumor-proliferation activity of lutein and zeaxanthin.
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char = t;code = 116
char = h;code = 104
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result sql = Lutein and zeaxanthin have various activities such as anti-age-related macular degeneration, anticataract, anticancer and cardiovascular diseases risk lowering, etc.; however, few studies have been reported on the role of free hydroxyl groups in the antitumor effects of lutein and zeaxanthin. The structure-activity relationship (SAR) of lutein and zeaxanthin di-acetylation derivatives has been investigated. The lutein and zeaxanthin were purified from corn protein residues and structurally modified by di-acetylation, which was characterized with UV/visible and HPLC/MS spectroscopy. The anti-proliferative effects of di-acetylated lutein or zeaxanthin on the human mouth epithelial cancer line KB cell were compared with controls of their original counterparts. Results showed that the anti-tumor activities of the di-acetylation of lutein and di-acetylation of zeaxanthin decreased significantly (p<0.05) at 50 micromol/L. Also the related IC50 dose was increased after di-acetylation. It was suggested that the hydroxyl groups contribute to the anti-tumor activity of lutein and zeaxanthin.
Publication: Asia Pac J Clin Nutr 2007 ;16 Suppl 1:447-52.
Publication Date: 2007
Study Author(s): Sun, Zhen;Yao, Huiyuan;
Institution: School of Food Science and Technology, Southern Yangtze University, 170 Huihe Road, Wuxi, Jiangsu Province, P. R. China 214036. [email protected]
Shortcut link to this study:
Publication Date: 2007
Study Author(s): Sun, Zhen;Yao, Huiyuan;
Institution: School of Food Science and Technology, Southern Yangtze University, 170 Huihe Road, Wuxi, Jiangsu Province, P. R. China 214036. [email protected]
Shortcut link to this study:
Lutein and zeaxanthin have various activities such as anti-age-related macular degeneration, anticataract, anticancer and cardiovascular diseases risk lowering, etc.; however, few studies have been reported on the role of free hydroxyl groups in the antitumor effects of lutein and zeaxanthin. The structure-activity relationship (SAR) of lutein and zeaxanthin di-acetylation derivatives has been investigated. The lutein and zeaxanthin were purified from corn protein residues and structurally modified by di-acetylation, which was characterized with UV/visible and HPLC/MS spectroscopy. The anti-proliferative effects of di-acetylated lutein or zeaxanthin on the human mouth epithelial cancer line KB cell were compared with controls of their original counterparts. Results showed that the anti-tumor activities of the di-acetylation of lutein and di-acetylation of zeaxanthin decreased significantly (p<0.05) at 50 micromol/L. Also the related IC50 dose was increased after di-acetylation. It was suggested that the hydroxyl groups contribute to the anti-tumor activity of lutein and zeaxanthin.
PMID: 17392148
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