|
|
char = A;code = 65
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = C;code = 67
char = C;code = 67
char = K;code = 75
char = -;code = 45
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = b;code = 98
char = a;code = 97
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = m;code = 109
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = .;code = 46
result sql = Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis.
Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis.char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = m;code = 109
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char = l;code = 108
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char = c;code = 99
char = h;code = 104
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char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = c;code = 99
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char = o;code = 111
char = l;code = 108
char = -;code = 45
char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
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char = r;code = 114
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char = m;code = 109
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
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char = v;code = 118
char = a;code = 97
char = g;code = 103
char = u;code = 117
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = h;code = 104
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char = d;code = 100
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char = e;code = 101
char = p;code = 112
char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = e;code = 101
char = x;code = 120
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = -;code = 45
char = d;code = 100
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = c;code = 99
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char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = y;code = 121
char = s;code = 115
char = t;code = 116
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = C;code = 67
char = C;code = 67
char = K;code = 75
char = );code = 41
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
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char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = t;code = 116
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char = b;code = 98
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = c;code = 99
char = e;code = 101
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char = s;code = 115
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = b;code = 98
char = e;code = 101
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char = r;code = 114
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char = n;code = 110
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char = b;code = 98
char = a;code = 97
char = s;code = 115
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char = e;code = 101
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = e;code = 101
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char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = ;code = 32
char = H;code = 72
char = i;code = 105
char = g;code = 103
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char = C;code = 67
char = C;code = 67
char = K;code = 75
char = ;code = 32
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char = a;code = 97
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char = ;code = 32
char = p;code = 112
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
char = ;code = 32
char = m;code = 109
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char = m;code = 109
char = b;code = 98
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char = a;code = 97
char = n;code = 110
char = e;code = 101
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char = (;code = 40
char = B;code = 66
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char = s;code = 115
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char = c;code = 99
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = f;code = 102
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char = m;code = 109
char = ;code = 32
char = s;code = 115
char = y;code = 121
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char = t;code = 116
char = a;code = 97
char = x;code = 120
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = S;code = 83
char = y;code = 121
char = n;code = 110
char = );code = 41
char = -;code = 45
char = 4;code = 52
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char = ;code = 32
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char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = S;code = 83
char = y;code = 121
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char = -;code = 45
char = 4;code = 52
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
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char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = m;code = 109
char = e;code = 101
char = m;code = 109
char = b;code = 98
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char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = M;code = 77
char = );code = 41
char = -;code = 45
char = S;code = 83
char = N;code = 78
char = A;code = 65
char = P;code = 80
char = -;code = 45
char = 2;code = 50
char = 3;code = 51
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = u;code = 117
char = l;code = 108
char = e;code = 101
char = -;code = 45
char = V;code = 86
char = A;code = 65
char = M;code = 77
char = P;code = 80
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
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char = t;code = 116
char = e;code = 101
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char = b;code = 98
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = ;code = 32
char = W;code = 87
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char = ;code = 32
char = n;code = 110
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char = w;code = 119
char = ;code = 32
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char = y;code = 121
char = p;code = 112
char = o;code = 111
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char = h;code = 104
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char = s;code = 115
char = i;code = 105
char = z;code = 122
char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = l;code = 108
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char = o;code = 111
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char = d;code = 100
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char = r;code = 114
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = c;code = 99
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char = c;code = 99
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char = b;code = 98
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char = a;code = 97
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char = p;code = 112
char = r;code = 114
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char = l;code = 108
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char = d;code = 100
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char = e;code = 101
char = s;code = 115
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char = o;code = 111
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char = C;code = 67
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char = K;code = 75
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char = s;code = 115
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char = e;code = 101
char = d;code = 100
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char = c;code = 99
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char = t;code = 116
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char = o;code = 111
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char = b;code = 98
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char = b;code = 98
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char = c;code = 99
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char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
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char = i;code = 105
char = s;code = 115
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char = a;code = 97
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char = e;code = 101
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char = l;code = 108
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char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = ;code = 32
char = P;code = 80
char = M;code = 77
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = t;code = 116
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char = s;code = 115
char = ;code = 32
char = (;code = 40
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
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char = c;code = 99
char = r;code = 114
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char = s;code = 115
char = c;code = 99
char = o;code = 111
char = p;code = 112
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
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char = o;code = 111
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char = ;code = 32
char = l;code = 108
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char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = C;code = 67
char = C;code = 67
char = K;code = 75
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = M;code = 77
char = -;code = 45
char = M;code = 77
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = 1;code = 49
char = 8;code = 56
char = c;code = 99
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char = ;code = 32
char = b;code = 98
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char = t;code = 116
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
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char = n;code = 110
char = c;code = 99
char = u;code = 117
char = b;code = 98
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = e;code = 101
char = n;code = 110
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = -;code = 45
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = C;code = 67
char = C;code = 67
char = K;code = 75
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = M;code = 77
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = 1;code = 49
char = 8;code = 56
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = B;code = 66
char = P;code = 80
char = M;code = 77
char = ,;code = 44
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = S;code = 83
char = N;code = 78
char = A;code = 65
char = R;code = 82
char = E;code = 69
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = m;code = 109
char = b;code = 98
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = B;code = 66
char = P;code = 80
char = M;code = 77
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = l;code = 108
char = y;code = 121
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char = ;code = 32
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
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char = o;code = 111
char = l;code = 108
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char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = -;code = 45
char = f;code = 102
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
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char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = m;code = 109
char = o;code = 111
char = r;code = 114
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = P;code = 80
char = M;code = 77
char = -;code = 45
char = M;code = 77
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = 1;code = 49
char = 8;code = 56
char = c;code = 99
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char = b;code = 98
char = e;code = 101
char = h;code = 104
char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
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char = t;code = 116
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = t;code = 116
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char = e;code = 101
char = a;code = 97
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char = i;code = 105
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char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
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char = n;code = 110
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = -;code = 45
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char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = C;code = 67
char = C;code = 67
char = K;code = 75
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = l;code = 108
char = e;code = 101
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char = n;code = 110
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char = a;code = 97
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char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = M;code = 77
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = 1;code = 49
char = 8;code = 56
char = c;code = 99
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char = d;code = 100
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char = s;code = 115
char = p;code = 112
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char = a;code = 97
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char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = B;code = 66
char = P;code = 80
char = M;code = 77
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
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char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = e;code = 101
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char = r;code = 114
char = a;code = 97
char = d;code = 100
char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = t;code = 116
char = r;code = 114
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char = b;code = 98
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = p;code = 112
char = a;code = 97
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char = c;code = 99
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char = e;code = 101
char = a;code = 97
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char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = e;code = 101
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char = t;code = 116
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = s;code = 115
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char = B;code = 66
char = P;code = 80
char = M;code = 77
char = -;code = 45
char = M;code = 77
char = u;code = 117
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char = c;code = 99
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char = 8;code = 56
char = c;code = 99
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char = t;code = 116
char = o;code = 111
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char = b;code = 98
char = e;code = 101
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = e;code = 101
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char = r;code = 114
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char = c;code = 99
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = p;code = 112
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = p;code = 112
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = C;code = 67
char = C;code = 67
char = K;code = 75
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
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char = s;code = 115
char = p;code = 112
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char = a;code = 97
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char = e;code = 101
char = m;code = 109
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char = t;code = 116
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char = n;code = 110
char = t;code = 116
char = o;code = 111
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = s;code = 115
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char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
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char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
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char = l;code = 108
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = S;code = 83
char = N;code = 78
char = A;code = 65
char = R;code = 82
char = E;code = 69
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
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char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = e;code = 101
char = s;code = 115
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char = i;code = 105
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = B;code = 66
char = P;code = 80
char = M;code = 77
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char = s;code = 115
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char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = o;code = 111
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char = b;code = 98
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char = a;code = 97
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char = o;code = 111
char = c;code = 99
char = y;code = 121
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char = i;code = 105
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char = i;code = 105
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char = t;code = 116
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char = a;code = 97
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char = a;code = 97
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char = w;code = 119
char = h;code = 104
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char = r;code = 114
char = e;code = 101
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char = z;code = 122
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char = o;code = 111
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char = a;code = 97
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = w;code = 119
char = o;code = 111
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char = l;code = 108
char = d;code = 100
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char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
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char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
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char = a;code = 97
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char = d;code = 100
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char = c;code = 99
char = a;code = 97
char = u;code = 117
char = s;code = 115
char = e;code = 101
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char = p;code = 112
char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
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result sql = The molecular mechanism of clinical alcohol-induced pancreatitis remains vague. We had reported that experimental high-dose cholecystokinin (CCK)-induced pancreatitis is in part because of excessive aberrant basolateral exocytosis. High-dose CCK caused Munc18c on basolateral plasma membrane (BPM) to dissociate from syntaxin (Syn)-4, activating Syn-4 to complex with plasma membrane (PM)-SNAP-23 and granule-VAMP to mediate basolateral exocytosis. We now hypothesize that alcohol could render the acinar cell BPM conducive to exocytosis by a similar mechanism. Weakly stimulating postprandial doses of alcohol (20-50 mM) inhibited postprandial low-dose CCK-stimulated secretion by blocking physiologic apical exocytosis and redirecting exocytosis to less-efficient basal PM (visualized by FM1-43 fluorescence imaging) and lateral PM sites (electron microscopy). Alcohol or low-dose CCK had no effect on PM-Munc18c, but alcohol preincubation enabled low-dose CCK to displace Munc18c from BPM, leading to SNARE complex assembly in the BPM. Similarly, alcohol diet-fed rats did not exhibit morphologic defects in the pancreas nor affected PM-Munc18c behavior, but subsequent intraperitoneal injections of low-dose CCK analog cerulein caused Munc18c displacement from BPM and cytosolic degradation, which contributed to pancreatitis. We conclude that alcohol induces BPM-Munc18c to become receptive to postprandial CCK-induced displacement into the cytosol, a process which facilitates SNARE complex assembly that in turn activates restricted BPM sites to become available for aberrant exocytosis into the interstitial space, where zymogen activation would take place and cause pancreatitis.
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result sql = Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis.
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char = s;code = 115
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char = e;code = 101
char = c;code = 99
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char = C;code = 67
char = C;code = 67
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char = f;code = 102
char = e;code = 101
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char = M;code = 77
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char = c;code = 99
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char = o;code = 111
char = l;code = 108
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char = r;code = 114
char = e;code = 101
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char = u;code = 117
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char = a;code = 97
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
char = b;code = 98
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char = e;code = 101
char = d;code = 100
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char = o;code = 111
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char = C;code = 67
char = C;code = 67
char = K;code = 75
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char = t;code = 116
char = o;code = 111
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char = d;code = 100
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char = s;code = 115
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char = a;code = 97
char = c;code = 99
char = e;code = 101
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char = M;code = 77
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char = n;code = 110
char = c;code = 99
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char = 8;code = 56
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = r;code = 114
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char = B;code = 66
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char = M;code = 77
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char = t;code = 116
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char = S;code = 83
char = N;code = 78
char = A;code = 65
char = R;code = 82
char = E;code = 69
char = ;code = 32
char = c;code = 99
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char = m;code = 109
char = p;code = 112
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char = s;code = 115
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char = n;code = 110
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = B;code = 66
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char = .;code = 46
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char = S;code = 83
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char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = i;code = 105
char = d;code = 100
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char = f;code = 102
char = e;code = 101
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char = C;code = 67
char = K;code = 75
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char = W;code = 87
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char = u;code = 117
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char = S;code = 83
char = N;code = 78
char = A;code = 65
char = R;code = 82
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result sql = The molecular mechanism of clinical alcohol-induced pancreatitis remains vague. We had reported that experimental high-dose cholecystokinin (CCK)-induced pancreatitis is in part because of excessive aberrant basolateral exocytosis. High-dose CCK caused Munc18c on basolateral plasma membrane (BPM) to dissociate from syntaxin (Syn)-4, activating Syn-4 to complex with plasma membrane (PM)-SNAP-23 and granule-VAMP to mediate basolateral exocytosis. We now hypothesize that alcohol could render the acinar cell BPM conducive to exocytosis by a similar mechanism. Weakly stimulating postprandial doses of alcohol (20-50 mM) inhibited postprandial low-dose CCK-stimulated secretion by blocking physiologic apical exocytosis and redirecting exocytosis to less-efficient basal PM (visualized by FM1-43 fluorescence imaging) and lateral PM sites (electron microscopy). Alcohol or low-dose CCK had no effect on PM-Munc18c, but alcohol preincubation enabled low-dose CCK to displace Munc18c from BPM, leading to SNARE complex assembly in the BPM. Similarly, alcohol diet-fed rats did not exhibit morphologic defects in the pancreas nor affected PM-Munc18c behavior, but subsequent intraperitoneal injections of low-dose CCK analog cerulein caused Munc18c displacement from BPM and cytosolic degradation, which contributed to pancreatitis. We conclude that alcohol induces BPM-Munc18c to become receptive to postprandial CCK-induced displacement into the cytosol, a process which facilitates SNARE complex assembly that in turn activates restricted BPM sites to become available for aberrant exocytosis into the interstitial space, where zymogen activation would take place and cause pancreatitis.
Publication: Traffic 2007 May ;8(5)::605-17.
Publication Date: 2007 May
Study Author(s): Lam, Patrick P L;Cosen Binker, Laura I;Lugea, Aurelia;Pandol, Stephen J;Gaisano, Herbert Y;
Institution: Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Shortcut link to this study:
Publication Date: 2007 May
Study Author(s): Lam, Patrick P L;Cosen Binker, Laura I;Lugea, Aurelia;Pandol, Stephen J;Gaisano, Herbert Y;
Institution: Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
Shortcut link to this study:
The molecular mechanism of clinical alcohol-induced pancreatitis remains vague. We had reported that experimental high-dose cholecystokinin (CCK)-induced pancreatitis is in part because of excessive aberrant basolateral exocytosis. High-dose CCK caused Munc18c on basolateral plasma membrane (BPM) to dissociate from syntaxin (Syn)-4, activating Syn-4 to complex with plasma membrane (PM)-SNAP-23 and granule-VAMP to mediate basolateral exocytosis. We now hypothesize that alcohol could render the acinar cell BPM conducive to exocytosis by a similar mechanism. Weakly stimulating postprandial doses of alcohol (20-50 mM) inhibited postprandial low-dose CCK-stimulated secretion by blocking physiologic apical exocytosis and redirecting exocytosis to less-efficient basal PM (visualized by FM1-43 fluorescence imaging) and lateral PM sites (electron microscopy). Alcohol or low-dose CCK had no effect on PM-Munc18c, but alcohol preincubation enabled low-dose CCK to displace Munc18c from BPM, leading to SNARE complex assembly in the BPM. Similarly, alcohol diet-fed rats did not exhibit morphologic defects in the pancreas nor affected PM-Munc18c behavior, but subsequent intraperitoneal injections of low-dose CCK analog cerulein caused Munc18c displacement from BPM and cytosolic degradation, which contributed to pancreatitis. We conclude that alcohol induces BPM-Munc18c to become receptive to postprandial CCK-induced displacement into the cytosol, a process which facilitates SNARE complex assembly that in turn activates restricted BPM sites to become available for aberrant exocytosis into the interstitial space, where zymogen activation would take place and cause pancreatitis.
PMID: 17451559
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