|
|
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result sql = Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.
Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.char = <;code = 60
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result sql = BACKGROUND : To address the hypothesis that liver steatosis causes systemic insulin resistance, we sought to determine the liver histological feature that most strongly contributes to insulin resistance in patients with nonalcoholic fatty liver disease (NAFLD).
METHODS : Liver biopsy specimens were obtained from 131 patients with clinically suspected NAFLD. The stage, grade of nonalcoholic steatohepatitis (NASH), and level of steatosis were scored and analyzed in relation to the homeostasis model assessment of insulin resistance (HOMA-IR) and the metabolic clearance rate (MCR), measured using the glucose clamp method.
RESULTS : In the univariate analysis, the degree of hepatic steatosis (r = 0.458, P < 0.001), stage (r = 0.360, P < 0.001), and grade (r = 0.349, P < 0.01) of NASH were significantly correlated with the HOMA-IR. Multiple regression analysis adjusting for age, sex, body mass index, and each histological score showed that steatosis was significantly and independently associated with HOMA-IR (coefficient = 1.42, P < 0.001), but not with the stage (coefficient = 0.33, P = 0.307) or grade (coefficient = 0.67, P = 0.134) of NASH. Similar independent relationships were observed between steatosis and MCR, but the relationship was weaker (coefficient = -0.98, P = 0.076).
CONCLUSIONS : Steatosis of the liver, but not the stage or the grade of NASH, is associated with insulin resistance in patients with NAFLD.
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result sql = Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.
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char = i;code = 105
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
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char = g;code = 103
char = h;code = 104
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char = t;code = 116
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char = d;code = 100
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char = t;code = 116
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char = e;code = 101
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char = l;code = 108
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char = v;code = 118
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char = r;code = 114
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char = h;code = 104
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = o;code = 111
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char = o;code = 111
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char = c;code = 99
char = a;code = 97
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char = f;code = 102
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char = a;code = 97
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char = u;code = 117
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char = t;code = 116
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char = a;code = 97
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char = m;code = 109
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char = s;code = 115
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
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char = n;code = 110
char = g;code = 103
char = l;code = 108
char = y;code = 121
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char = c;code = 99
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char = t;code = 116
char = r;code = 114
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char = b;code = 98
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char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = t;code = 116
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char = i;code = 105
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char = s;code = 115
char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = c;code = 99
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char = p;code = 112
char = a;code = 97
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char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
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char = n;code = 110
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char = n;code = 110
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
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char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = N;code = 78
char = A;code = 65
char = F;code = 70
char = L;code = 76
char = D;code = 68
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = b;code = 98
char = >;code = 62
char = L;code = 76
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char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = b;code = 98
char = i;code = 105
char = o;code = 111
char = p;code = 112
char = s;code = 115
char = y;code = 121
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char = s;code = 115
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char = e;code = 101
char = c;code = 99
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = o;code = 111
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char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
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char = d;code = 100
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char = f;code = 102
char = r;code = 114
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char = m;code = 109
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char = 1;code = 49
char = 3;code = 51
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
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char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = s;code = 115
char = u;code = 117
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = N;code = 78
char = A;code = 65
char = F;code = 70
char = L;code = 76
char = D;code = 68
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
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char = s;code = 115
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char = a;code = 97
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char = r;code = 114
char = a;code = 97
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char = f;code = 102
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char = n;code = 110
char = a;code = 97
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char = c;code = 99
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char = h;code = 104
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = s;code = 115
char = t;code = 116
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
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char = (;code = 40
char = N;code = 78
char = A;code = 65
char = S;code = 83
char = H;code = 72
char = );code = 41
char = ,;code = 44
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char = a;code = 97
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char = e;code = 101
char = l;code = 108
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char = f;code = 102
char = ;code = 32
char = s;code = 115
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char = e;code = 101
char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
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char = u;code = 117
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char = H;code = 72
char = O;code = 79
char = M;code = 77
char = A;code = 65
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char = ;code = 32
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char = b;code = 98
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char = c;code = 99
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char = e;code = 101
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char = M;code = 77
char = C;code = 67
char = R;code = 82
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char = ,;code = 44
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char = m;code = 109
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char = a;code = 97
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char = a;code = 97
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char = p;code = 112
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char = h;code = 104
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char = <;code = 60
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char = >;code = 62
char = <;code = 60
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char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
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char = <;code = 60
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char = b;code = 98
char = >;code = 62
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = u;code = 117
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char = v;code = 118
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char = a;code = 97
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char = a;code = 97
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char = y;code = 121
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char = a;code = 97
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char = 4;code = 52
char = 5;code = 53
char = 8;code = 56
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char = P;code = 80
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char = 0;code = 48
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char = 9;code = 57
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char = N;code = 78
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char = S;code = 83
char = H;code = 72
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char = w;code = 119
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char = H;code = 72
char = O;code = 79
char = M;code = 77
char = A;code = 65
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char = I;code = 73
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char = .;code = 46
char = ;code = 32
char = M;code = 77
char = u;code = 117
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char = t;code = 116
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char = l;code = 108
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result sql = BACKGROUND : To address the hypothesis that liver steatosis causes systemic insulin resistance, we sought to determine the liver histological feature that most strongly contributes to insulin resistance in patients with nonalcoholic fatty liver disease (NAFLD).
METHODS : Liver biopsy specimens were obtained from 131 patients with clinically suspected NAFLD. The stage, grade of nonalcoholic steatohepatitis (NASH), and level of steatosis were scored and analyzed in relation to the homeostasis model assessment of insulin resistance (HOMA-IR) and the metabolic clearance rate (MCR), measured using the glucose clamp method.
RESULTS : In the univariate analysis, the degree of hepatic steatosis (r = 0.458, P < 0.001), stage (r = 0.360, P < 0.001), and grade (r = 0.349, P < 0.01) of NASH were significantly correlated with the HOMA-IR. Multiple regression analysis adjusting for age, sex, body mass index, and each histological score showed that steatosis was significantly and independently associated with HOMA-IR (coefficient = 1.42, P < 0.001), but not with the stage (coefficient = 0.33, P = 0.307) or grade (coefficient = 0.67, P = 0.134) of NASH. Similar independent relationships were observed between steatosis and MCR, but the relationship was weaker (coefficient = -0.98, P = 0.076).
CONCLUSIONS : Steatosis of the liver, but not the stage or the grade of NASH, is associated with insulin resistance in patients with NAFLD.
Publication: J. Gastroenterol. 2007 Apr ;42(4)::312-7.
Publication Date: 2007 Apr
Study Author(s): Sakurai, Masaru;Takamura, Toshinari;Ota, Tsuguhito;Ando, Hitoshi;Akahori, Hiroshi;Kaji, Kyosuke;Sasaki, Motoko;Nakanuma, Yasuni;Miura, Katsuyuki;Kaneko, Shuichi;
Institution: Department of Disease Control and Homeostacis, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
Shortcut link to this study:
Publication Date: 2007 Apr
Study Author(s): Sakurai, Masaru;Takamura, Toshinari;Ota, Tsuguhito;Ando, Hitoshi;Akahori, Hiroshi;Kaji, Kyosuke;Sasaki, Motoko;Nakanuma, Yasuni;Miura, Katsuyuki;Kaneko, Shuichi;
Institution: Department of Disease Control and Homeostacis, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.
Shortcut link to this study:
BACKGROUND : To address the hypothesis that liver steatosis causes systemic insulin resistance, we sought to determine the liver histological feature that most strongly contributes to insulin resistance in patients with nonalcoholic fatty liver disease (NAFLD).
METHODS : Liver biopsy specimens were obtained from 131 patients with clinically suspected NAFLD. The stage, grade of nonalcoholic steatohepatitis (NASH), and level of steatosis were scored and analyzed in relation to the homeostasis model assessment of insulin resistance (HOMA-IR) and the metabolic clearance rate (MCR), measured using the glucose clamp method.
RESULTS : In the univariate analysis, the degree of hepatic steatosis (r = 0.458, P < 0.001), stage (r = 0.360, P < 0.001), and grade (r = 0.349, P < 0.01) of NASH were significantly correlated with the HOMA-IR. Multiple regression analysis adjusting for age, sex, body mass index, and each histological score showed that steatosis was significantly and independently associated with HOMA-IR (coefficient = 1.42, P < 0.001), but not with the stage (coefficient = 0.33, P = 0.307) or grade (coefficient = 0.67, P = 0.134) of NASH. Similar independent relationships were observed between steatosis and MCR, but the relationship was weaker (coefficient = -0.98, P = 0.076).
CONCLUSIONS : Steatosis of the liver, but not the stage or the grade of NASH, is associated with insulin resistance in patients with NAFLD.
METHODS : Liver biopsy specimens were obtained from 131 patients with clinically suspected NAFLD. The stage, grade of nonalcoholic steatohepatitis (NASH), and level of steatosis were scored and analyzed in relation to the homeostasis model assessment of insulin resistance (HOMA-IR) and the metabolic clearance rate (MCR), measured using the glucose clamp method.
RESULTS : In the univariate analysis, the degree of hepatic steatosis (r = 0.458, P < 0.001), stage (r = 0.360, P < 0.001), and grade (r = 0.349, P < 0.01) of NASH were significantly correlated with the HOMA-IR. Multiple regression analysis adjusting for age, sex, body mass index, and each histological score showed that steatosis was significantly and independently associated with HOMA-IR (coefficient = 1.42, P < 0.001), but not with the stage (coefficient = 0.33, P = 0.307) or grade (coefficient = 0.67, P = 0.134) of NASH. Similar independent relationships were observed between steatosis and MCR, but the relationship was weaker (coefficient = -0.98, P = 0.076).
CONCLUSIONS : Steatosis of the liver, but not the stage or the grade of NASH, is associated with insulin resistance in patients with NAFLD.
PMID: 17464461
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