|
|
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char = a;code = 97
char = t;code = 116
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char = .;code = 46
result sql = Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate.
Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate.char = <;code = 60
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char = N;code = 78
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char = R;code = 82
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char = C;code = 67
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char = O;code = 79
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char = ;code = 32
char = :;code = 58
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char = <;code = 60
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char = .;code = 46
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char = C;code = 67
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char = 6;code = 54
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char = a;code = 97
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char = o;code = 111
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char = a;code = 97
char = l;code = 108
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char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
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char = h;code = 104
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = V;code = 86
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = );code = 41
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = m;code = 109
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char = a;code = 97
char = s;code = 115
char = u;code = 117
char = r;code = 114
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = e;code = 101
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char = n;code = 110
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = b;code = 98
char = y;code = 121
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char = E;code = 69
char = L;code = 76
char = I;code = 73
char = S;code = 83
char = A;code = 65
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = s;code = 115
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = A;code = 65
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char = n;code = 110
char = e;code = 101
char = x;code = 120
char = i;code = 105
char = n;code = 110
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char = V;code = 86
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char = f;code = 102
char = l;code = 108
char = u;code = 117
char = o;code = 111
char = r;code = 114
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char = s;code = 115
char = c;code = 99
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = F;code = 70
char = I;code = 73
char = T;code = 84
char = C;code = 67
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char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = I;code = 73
char = P;code = 80
char = 6;code = 54
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = P;code = 80
char = A;code = 65
char = N;code = 78
char = C;code = 67
char = -;code = 45
char = 1;code = 49
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = 2;code = 50
char = 4;code = 52
char = ,;code = 44
char = ;code = 32
char = 4;code = 52
char = 8;code = 56
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 7;code = 55
char = 2;code = 50
char = ;code = 32
char = h;code = 104
char = ;code = 32
char = c;code = 99
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char = m;code = 109
char = p;code = 112
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
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char = .;code = 46
char = ;code = 32
char = G;code = 71
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = M;code = 77
char = I;code = 73
char = A;code = 65
char = P;code = 80
char = A;code = 65
char = C;code = 67
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = d;code = 100
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = e;code = 101
char = a;code = 97
char = c;code = 99
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char = a;code = 97
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char = a;code = 97
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char = o;code = 111
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char = e;code = 101
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char = ;code = 32
char = b;code = 98
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char = d;code = 100
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char = i;code = 105
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char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = r;code = 114
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = r;code = 114
char = e;code = 101
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char = e;code = 101
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char = A;code = 65
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char = e;code = 101
char = a;code = 97
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char = y;code = 121
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char = a;code = 97
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char = o;code = 111
char = p;code = 112
char = t;code = 116
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char = i;code = 105
char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = t;code = 116
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char = i;code = 105
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = c;code = 99
char = h;code = 104
char = i;code = 105
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char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
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char = i;code = 105
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char = b;code = 98
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char = t;code = 116
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = s;code = 115
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char = (;code = 40
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = o;code = 111
char = m;code = 109
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char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = a;code = 97
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char = s;code = 115
char = o;code = 111
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char = i;code = 105
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char = e;code = 101
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char = a;code = 97
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char = o;code = 111
char = p;code = 112
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char = o;code = 111
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char = i;code = 105
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char = a;code = 97
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char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = h;code = 104
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char = r;code = 114
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char = l;code = 108
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char = P;code = 80
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char = <;code = 60
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char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = P;code = 80
char = 6;code = 54
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char = d;code = 100
char = u;code = 117
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char = V;code = 86
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char = G;code = 71
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char = 6;code = 54
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char = f;code = 102
char = i;code = 105
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char = V;code = 86
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char = a;code = 97
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char = M;code = 77
char = I;code = 73
char = A;code = 65
char = P;code = 80
char = A;code = 65
char = C;code = 67
char = A;code = 65
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char = a;code = 97
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char = l;code = 108
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char = (;code = 40
char = P;code = 80
char = ;code = 32
char = <;code = 60
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char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 2;code = 50
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char = .;code = 46
char = <;code = 60
char = b;code = 98
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
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char = ;code = 32
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char = b;code = 98
char = i;code = 105
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char = e;code = 101
char = d;code = 100
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = t;code = 116
char = h;code = 104
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char = v;code = 118
char = a;code = 97
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char = c;code = 99
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = c;code = 99
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result sql = INTRODUCTION : Pancreatic cancer is an extremely virulent form of cancer with few effective treatments. Catechin and inositol hexaphosphate (IP6), two naturally occurring molecules found in green tea and high-fiber foods, respectively, are compounds that have been shown to demonstrate anti-proliferative effects when administered as single therapeutic agents against a number of cancers. We hypothesized that, alone and in combination, IP6 and catechin would be effective against pancreatic cancer.
MATERIALS AND METHODS : Pancreatic (PANC-1 and MIAPACA) cancer cell lines were cultured and treated with IP6 (0.8 mM/well), catechin (100 microM/well), and the combination of the two. Cell viability was measured by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) at 24, 48, and 72 h. Vascular endothelial growth factor (VEGF) was measured in the cell supernatants by ELISA. Apoptosis was evaluated by Annexin V-fluorescein isothiocyanate (FITC).
RESULTS : The combination of catechin and IP6 significantly inhibited proliferation in the PANC-1 cell line at 24, 48, and 72 h compared to single agents (P < 0.001). Growth of the MIAPACA cell line was inhibited (P < 0.01) by each agent alone, but additive inhibitory effects were not seen. An increase in early apoptosis was attributed to catechin therapy in both cell lines (P < 0.01). The combination of these agents also increased early apoptotic activity when compared to the control (P < 0.001). IP6 reduced VEGF in both cell lines (P < 0.01). In combination, catechin and IP6 amplified VEGF reduction compared to each agent in MIAPACA and control (P < 0.002).
CONCLUSIONS : These results, combined with the prevalence of these compounds in safe, naturally occurring foods, make catechin and IP6 attractive therapies for treatment, and possibly in preventative trials, of pancreatic cancer.
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result sql = Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate.
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char = 6;code = 54
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char = 0;code = 48
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char = C;code = 67
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char = l;code = 108
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char = r;code = 114
char = a;code = 97
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char = o;code = 111
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char = i;code = 105
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char = m;code = 109
char = i;code = 105
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char = M;code = 77
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char = T;code = 84
char = );code = 41
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char = a;code = 97
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char = 2;code = 50
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char = 4;code = 52
char = 8;code = 56
char = ,;code = 44
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char = a;code = 97
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char = ;code = 32
char = 7;code = 55
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char = h;code = 104
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char = V;code = 86
char = a;code = 97
char = s;code = 115
char = c;code = 99
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char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = d;code = 100
char = o;code = 111
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char = a;code = 97
char = l;code = 108
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char = g;code = 103
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char = f;code = 102
char = a;code = 97
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char = F;code = 70
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char = ;code = 32
char = w;code = 119
char = a;code = 97
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char = m;code = 109
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char = a;code = 97
char = s;code = 115
char = u;code = 117
char = r;code = 114
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char = d;code = 100
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char = i;code = 105
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = s;code = 115
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char = a;code = 97
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char = t;code = 116
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char = b;code = 98
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char = E;code = 69
char = L;code = 76
char = I;code = 73
char = S;code = 83
char = A;code = 65
char = .;code = 46
char = ;code = 32
char = A;code = 65
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char = s;code = 115
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = e;code = 101
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char = a;code = 97
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char = u;code = 117
char = a;code = 97
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char = e;code = 101
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char = n;code = 110
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char = x;code = 120
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char = n;code = 110
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char = V;code = 86
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char = l;code = 108
char = u;code = 117
char = o;code = 111
char = r;code = 114
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char = s;code = 115
char = c;code = 99
char = e;code = 101
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char = n;code = 110
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char = i;code = 105
char = s;code = 115
char = o;code = 111
char = t;code = 116
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char = c;code = 99
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = (;code = 40
char = F;code = 70
char = I;code = 73
char = T;code = 84
char = C;code = 67
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
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char = >;code = 62
char = <;code = 60
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char = /;code = 47
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char = <;code = 60
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char = >;code = 62
char = R;code = 82
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char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
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char = <;code = 60
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char = e;code = 101
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char = P;code = 80
char = A;code = 65
char = N;code = 78
char = C;code = 67
char = -;code = 45
char = 1;code = 49
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char = c;code = 99
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char = ,;code = 44
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char = 4;code = 52
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char = ,;code = 44
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char = P;code = 80
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char = <;code = 60
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char = .;code = 46
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char = 0;code = 48
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char = .;code = 46
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char = G;code = 71
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char = t;code = 116
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char = f;code = 102
char = ;code = 32
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char = M;code = 77
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char = A;code = 65
char = P;code = 80
char = A;code = 65
char = C;code = 67
char = A;code = 65
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char = c;code = 99
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char = <;code = 60
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char = f;code = 102
char = e;code = 101
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char = 0;code = 48
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char = I;code = 73
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char = u;code = 117
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result sql = INTRODUCTION : Pancreatic cancer is an extremely virulent form of cancer with few effective treatments. Catechin and inositol hexaphosphate (IP6), two naturally occurring molecules found in green tea and high-fiber foods, respectively, are compounds that have been shown to demonstrate anti-proliferative effects when administered as single therapeutic agents against a number of cancers. We hypothesized that, alone and in combination, IP6 and catechin would be effective against pancreatic cancer.
MATERIALS AND METHODS : Pancreatic (PANC-1 and MIAPACA) cancer cell lines were cultured and treated with IP6 (0.8 mM/well), catechin (100 microM/well), and the combination of the two. Cell viability was measured by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) at 24, 48, and 72 h. Vascular endothelial growth factor (VEGF) was measured in the cell supernatants by ELISA. Apoptosis was evaluated by Annexin V-fluorescein isothiocyanate (FITC).
RESULTS : The combination of catechin and IP6 significantly inhibited proliferation in the PANC-1 cell line at 24, 48, and 72 h compared to single agents (P < 0.001). Growth of the MIAPACA cell line was inhibited (P < 0.01) by each agent alone, but additive inhibitory effects were not seen. An increase in early apoptosis was attributed to catechin therapy in both cell lines (P < 0.01). The combination of these agents also increased early apoptotic activity when compared to the control (P < 0.001). IP6 reduced VEGF in both cell lines (P < 0.01). In combination, catechin and IP6 amplified VEGF reduction compared to each agent in MIAPACA and control (P < 0.002).
CONCLUSIONS : These results, combined with the prevalence of these compounds in safe, naturally occurring foods, make catechin and IP6 attractive therapies for treatment, and possibly in preventative trials, of pancreatic cancer.
Publication: J. Surg. Res. 2007 Jul ;141(1)::115-9.
Publication Date: 2007 Jul
Study Author(s): McMillan, Brian;Riggs, Dale R;Jackson, Barbara J;Cunningham, Cynthia;McFadden, David W;
Institution: Department Of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, West Virginia, USA.
Shortcut link to this study:
Publication Date: 2007 Jul
Study Author(s): McMillan, Brian;Riggs, Dale R;Jackson, Barbara J;Cunningham, Cynthia;McFadden, David W;
Institution: Department Of Surgery, Robert C. Byrd Health Science Center, West Virginia University, Morgantown, West Virginia, USA.
Shortcut link to this study:
INTRODUCTION : Pancreatic cancer is an extremely virulent form of cancer with few effective treatments. Catechin and inositol hexaphosphate (IP6), two naturally occurring molecules found in green tea and high-fiber foods, respectively, are compounds that have been shown to demonstrate anti-proliferative effects when administered as single therapeutic agents against a number of cancers. We hypothesized that, alone and in combination, IP6 and catechin would be effective against pancreatic cancer.
MATERIALS AND METHODS : Pancreatic (PANC-1 and MIAPACA) cancer cell lines were cultured and treated with IP6 (0.8 mM/well), catechin (100 microM/well), and the combination of the two. Cell viability was measured by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) at 24, 48, and 72 h. Vascular endothelial growth factor (VEGF) was measured in the cell supernatants by ELISA. Apoptosis was evaluated by Annexin V-fluorescein isothiocyanate (FITC).
RESULTS : The combination of catechin and IP6 significantly inhibited proliferation in the PANC-1 cell line at 24, 48, and 72 h compared to single agents (P < 0.001). Growth of the MIAPACA cell line was inhibited (P < 0.01) by each agent alone, but additive inhibitory effects were not seen. An increase in early apoptosis was attributed to catechin therapy in both cell lines (P < 0.01). The combination of these agents also increased early apoptotic activity when compared to the control (P < 0.001). IP6 reduced VEGF in both cell lines (P < 0.01). In combination, catechin and IP6 amplified VEGF reduction compared to each agent in MIAPACA and control (P < 0.002).
CONCLUSIONS : These results, combined with the prevalence of these compounds in safe, naturally occurring foods, make catechin and IP6 attractive therapies for treatment, and possibly in preventative trials, of pancreatic cancer.
MATERIALS AND METHODS : Pancreatic (PANC-1 and MIAPACA) cancer cell lines were cultured and treated with IP6 (0.8 mM/well), catechin (100 microM/well), and the combination of the two. Cell viability was measured by 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) at 24, 48, and 72 h. Vascular endothelial growth factor (VEGF) was measured in the cell supernatants by ELISA. Apoptosis was evaluated by Annexin V-fluorescein isothiocyanate (FITC).
RESULTS : The combination of catechin and IP6 significantly inhibited proliferation in the PANC-1 cell line at 24, 48, and 72 h compared to single agents (P < 0.001). Growth of the MIAPACA cell line was inhibited (P < 0.01) by each agent alone, but additive inhibitory effects were not seen. An increase in early apoptosis was attributed to catechin therapy in both cell lines (P < 0.01). The combination of these agents also increased early apoptotic activity when compared to the control (P < 0.001). IP6 reduced VEGF in both cell lines (P < 0.01). In combination, catechin and IP6 amplified VEGF reduction compared to each agent in MIAPACA and control (P < 0.002).
CONCLUSIONS : These results, combined with the prevalence of these compounds in safe, naturally occurring foods, make catechin and IP6 attractive therapies for treatment, and possibly in preventative trials, of pancreatic cancer.
PMID: 17574044
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