|
|
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char = ?;code = 63
result sql = Alanine-aminotransferase: an early marker for insulin resistance?
Alanine-aminotransferase: an early marker for insulin resistance?char = I;code = 73
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char = e;code = 101
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char = P;code = 80
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char = s;code = 115
char = o;code = 111
char = c;code = 99
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char = i;code = 105
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char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = A;code = 65
char = L;code = 76
char = T;code = 84
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = T;code = 84
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char = H;code = 72
char = D;code = 68
char = L;code = 76
char = c;code = 99
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result sql = In a population-based sample, after excluding alcohol consumption, hepatotoxic drugs and hepatitis B and C infected, we investigated if alanine-aminotransferase (ALT) was associated with metabolic syndrome and insulin resistance, and if this association was caused by non-alcoholic fatty liver disease (NAFLD). The sample (432 female and 119 male) was divided into two ALT thresholds corresponding to the 50th and 75th percentiles (P) (female > or = 15 and > or = 19 U/L; male > or = 17 and > or = 23 U/I, respectively). Blood pressure, body mass index, waist circumference, cholesterol, HDL cholesterol (HDLc), triglyceride (TG), TG/HDLc ratio, glycemia and homeostasis model assessment of insulin resistance (HOMA-IR) were compared between those above and below each ALT threshold. Female placed above the 50th P of ALT had higher levels of TG/HDLc ratio (p=0.029), glycemia (p=0.028), and homeostasis model assessment of insulin resistance, (p=0.045), and above the 75th P had higher SBP (p=0.036), DBP (p=0.018), TG (p=0.024), TG/HDLc ratio (p=0.028), glycemia (p=0.004) and HOMA-IR (p=0.0014). Male placed above the 50th P of ALT had higher BMI (p=0.017) and TG/HDLc ratio (p=0.048), and above the 75th P had lower values of HDLc (p=0.042). Only 16.5% of women and 14.5% of men, above the 75th P of ALT, showed an increase in liver brightness in the echography. This work shows in woman an early association of ALT with TG/HDLc ratio and HOMA-IR. Since the last two are independent predictors of cardiovascular risk, attention should be drawn to ALT values near the upper limit of the normal range even in the absence of NAFLD and obesity.
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char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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result sql = Alanine-aminotransferase: an early marker for insulin resistance?
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char = e;code = 101
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char = o;code = 111
char = l;code = 108
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char = c;code = 99
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char = n;code = 110
char = s;code = 115
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char = m;code = 109
char = p;code = 112
char = t;code = 116
char = i;code = 105
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char = ,;code = 44
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = r;code = 114
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char = g;code = 103
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = B;code = 66
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = C;code = 67
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = e;code = 101
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ,;code = 44
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char = w;code = 119
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = i;code = 105
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char = ;code = 32
char = a;code = 97
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char = a;code = 97
char = n;code = 110
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char = n;code = 110
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char = -;code = 45
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = f;code = 102
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char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = A;code = 65
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char = T;code = 84
char = );code = 41
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char = w;code = 119
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = m;code = 109
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char = t;code = 116
char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = n;code = 110
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char = r;code = 114
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char = a;code = 97
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char = d;code = 100
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char = n;code = 110
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char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = i;code = 105
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = n;code = 110
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
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char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = d;code = 100
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char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = (;code = 40
char = N;code = 78
char = A;code = 65
char = F;code = 70
char = L;code = 76
char = D;code = 68
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = a;code = 97
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
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char = (;code = 40
char = 4;code = 52
char = 3;code = 51
char = 2;code = 50
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char = f;code = 102
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = 1;code = 49
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char = e;code = 101
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char = w;code = 119
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
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char = t;code = 116
char = w;code = 119
char = o;code = 111
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char = A;code = 65
char = L;code = 76
char = T;code = 84
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = h;code = 104
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char = d;code = 100
char = s;code = 115
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char = c;code = 99
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char = r;code = 114
char = r;code = 114
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char = s;code = 115
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char = =;code = 61
char = ;code = 32
char = 2;code = 50
char = 3;code = 51
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char = U;code = 85
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char = I;code = 73
char = ,;code = 44
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char = r;code = 114
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char = s;code = 115
char = p;code = 112
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char = c;code = 99
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char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = B;code = 66
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char = s;code = 115
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char = ;code = 32
char = H;code = 72
char = D;code = 68
char = L;code = 76
char = ;code = 32
char = c;code = 99
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char = L;code = 76
char = c;code = 99
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char = ,;code = 44
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char = r;code = 114
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char = T;code = 84
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char = ,;code = 44
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char = T;code = 84
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char = H;code = 72
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char = a;code = 97
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char = O;code = 79
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char = T;code = 84
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char = H;code = 72
char = D;code = 68
char = L;code = 76
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char = r;code = 114
char = a;code = 97
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char = i;code = 105
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char = .;code = 46
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char = a;code = 97
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char = a;code = 97
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char = m;code = 109
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char = u;code = 117
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char = c;code = 99
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char = ,;code = 44
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char = (;code = 40
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result sql = In a population-based sample, after excluding alcohol consumption, hepatotoxic drugs and hepatitis B and C infected, we investigated if alanine-aminotransferase (ALT) was associated with metabolic syndrome and insulin resistance, and if this association was caused by non-alcoholic fatty liver disease (NAFLD). The sample (432 female and 119 male) was divided into two ALT thresholds corresponding to the 50th and 75th percentiles (P) (female > or = 15 and > or = 19 U/L; male > or = 17 and > or = 23 U/I, respectively). Blood pressure, body mass index, waist circumference, cholesterol, HDL cholesterol (HDLc), triglyceride (TG), TG/HDLc ratio, glycemia and homeostasis model assessment of insulin resistance (HOMA-IR) were compared between those above and below each ALT threshold. Female placed above the 50th P of ALT had higher levels of TG/HDLc ratio (p=0.029), glycemia (p=0.028), and homeostasis model assessment of insulin resistance, (p=0.045), and above the 75th P had higher SBP (p=0.036), DBP (p=0.018), TG (p=0.024), TG/HDLc ratio (p=0.028), glycemia (p=0.004) and HOMA-IR (p=0.0014). Male placed above the 50th P of ALT had higher BMI (p=0.017) and TG/HDLc ratio (p=0.048), and above the 75th P had lower values of HDLc (p=0.042). Only 16.5% of women and 14.5% of men, above the 75th P of ALT, showed an increase in liver brightness in the echography. This work shows in woman an early association of ALT with TG/HDLc ratio and HOMA-IR. Since the last two are independent predictors of cardiovascular risk, attention should be drawn to ALT values near the upper limit of the normal range even in the absence of NAFLD and obesity.
Publication: Medicina (B Aires) 2007 ;67(2)::125-30.
Publication Date: 2007
Study Author(s): Salazar, Martin R;Carbajal, Horacio A;Curciarello, Jose O;Aizpurua, Marcelo;Adrover, Raul E;Riondet, Beatriz;
Institution: Centro de Referencia Provincial de Hipertensión Arterial, Ministerio de Salud, Provincia de Buenos Aires. [email protected]
Shortcut link to this study:
Publication Date: 2007
Study Author(s): Salazar, Martin R;Carbajal, Horacio A;Curciarello, Jose O;Aizpurua, Marcelo;Adrover, Raul E;Riondet, Beatriz;
Institution: Centro de Referencia Provincial de Hipertensión Arterial, Ministerio de Salud, Provincia de Buenos Aires. [email protected]
Shortcut link to this study:
In a population-based sample, after excluding alcohol consumption, hepatotoxic drugs and hepatitis B and C infected, we investigated if alanine-aminotransferase (ALT) was associated with metabolic syndrome and insulin resistance, and if this association was caused by non-alcoholic fatty liver disease (NAFLD). The sample (432 female and 119 male) was divided into two ALT thresholds corresponding to the 50th and 75th percentiles (P) (female > or = 15 and > or = 19 U/L; male > or = 17 and > or = 23 U/I, respectively). Blood pressure, body mass index, waist circumference, cholesterol, HDL cholesterol (HDLc), triglyceride (TG), TG/HDLc ratio, glycemia and homeostasis model assessment of insulin resistance (HOMA-IR) were compared between those above and below each ALT threshold. Female placed above the 50th P of ALT had higher levels of TG/HDLc ratio (p=0.029), glycemia (p=0.028), and homeostasis model assessment of insulin resistance, (p=0.045), and above the 75th P had higher SBP (p=0.036), DBP (p=0.018), TG (p=0.024), TG/HDLc ratio (p=0.028), glycemia (p=0.004) and HOMA-IR (p=0.0014). Male placed above the 50th P of ALT had higher BMI (p=0.017) and TG/HDLc ratio (p=0.048), and above the 75th P had lower values of HDLc (p=0.042). Only 16.5% of women and 14.5% of men, above the 75th P of ALT, showed an increase in liver brightness in the echography. This work shows in woman an early association of ALT with TG/HDLc ratio and HOMA-IR. Since the last two are independent predictors of cardiovascular risk, attention should be drawn to ALT values near the upper limit of the normal range even in the absence of NAFLD and obesity.
PMID: 17593595
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