|
|
char = O;code = 79
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char = l;code = 108
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char = f;code = 102
char = i;code = 105
char = e;code = 101
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char = s;code = 115
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char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = n;code = 110
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char = i;code = 105
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char = v;code = 118
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char = l;code = 108
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char = o;code = 111
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char = o;code = 111
char = s;code = 115
char = e;code = 101
char = n;code = 110
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char = t;code = 116
char = i;code = 105
char = z;code = 122
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char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = r;code = 114
char = .;code = 46
result sql = Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer.
Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer.char = W;code = 87
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char = ;code = 32
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char = (;code = 40
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char = );code = 41
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char = m;code = 109
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char = e;code = 101
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char = l;code = 108
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char = c;code = 99
char = o;code = 111
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char = o;code = 111
char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
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char = t;code = 116
char = o;code = 111
char = ;code = 32
char = o;code = 111
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char = g;code = 103
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char = i;code = 105
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char = O;code = 79
char = S;code = 83
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char = );code = 41
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char = n;code = 110
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char = b;code = 98
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char = l;code = 108
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char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
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result sql = We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size ( approximately 20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.
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result sql = Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer.
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result sql = We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size ( approximately 20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.
Publication: Nano Lett. 2007 Sep ;7(9)::2835-42.
Publication Date: 2007 Sep
Study Author(s): Ohulchanskyy, Tymish Y;Roy, Indrajit;Goswami, Lalit N;Chen, Yihui;Bergey, Earl J;Pandey, Ravindra K;Oseroff, Allan R;Prasad, Paras N;
Institution: Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York, USA.
Shortcut link to this study:
Publication Date: 2007 Sep
Study Author(s): Ohulchanskyy, Tymish Y;Roy, Indrajit;Goswami, Lalit N;Chen, Yihui;Bergey, Earl J;Pandey, Ravindra K;Oseroff, Allan R;Prasad, Paras N;
Institution: Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, New York, USA.
Shortcut link to this study:
We report a novel nanoformulation of a photosensitizer (PS), for photodynamic therapy (PDT) of cancer, where the PS molecules are covalently incorporated into organically modified silica (ORMOSIL) nanoparticles. We found that the covalently incorporated PS molecules retained their spectroscopic and functional properties and could robustly generate cytotoxic singlet oxygen molecules upon photoirradiation. The synthesized nanoparticles are of ultralow size ( approximately 20 nm) and are highly monodispersed and stable in aqueous suspension. The advantage offered by this covalently linked nanofabrication is that the drug is not released during systemic circulation, which is often a problem with physical encapsulation. These nanoparticles are also avidly uptaken by tumor cells in vitro and demonstrate phototoxic action, thereby highlighting their potential in diagnosis and PDT of cancer.
PMID: 17718587
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