|
|
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result sql = Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.char = E;code = 69
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result sql = Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1alpha,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1alpha,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.
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result sql = Vitamin D signalling pathways in cancer: potential for anticancer therapeutics.
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result sql = Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1alpha,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1alpha,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.
Publication: Nat. Rev. Cancer 2007 Sep ;7(9)::684-700.
Publication Date: 2007 Sep
Study Author(s): Deeb, Kristin K;Trump, Donald L;Johnson, Candace S;
Institution: Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Shortcut link to this study:
Publication Date: 2007 Sep
Study Author(s): Deeb, Kristin K;Trump, Donald L;Johnson, Candace S;
Institution: Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, New York, USA.
Shortcut link to this study:
Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1alpha,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1alpha,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1alpha,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.
PMID: 17721433
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