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result sql = Iodine-131 radio-guided surgery in differentiated thyroid cancer: outcome on 31 patients and review of the literature.

Iodine-131 radio-guided surgery in differentiated thyroid cancer: outcome on 31 patients and review of the literature.

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char = 5;code = 53
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char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
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char = t;code = 116
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char = r;code = 114
char = o;code = 111
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char = h;code = 104
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char = a;code = 97
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char = w;code = 119
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char = b;code = 98
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char = l;code = 108
char = a;code = 97
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char = a;code = 97
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char = c;code = 99
char = k;code = 107
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char = e;code = 101
char = x;code = 120
char = p;code = 112
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char = o;code = 111
char = r;code = 114
char = a;code = 97
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = u;code = 117
char = s;code = 115
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char = n;code = 110
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char = a;code = 97
char = ;code = 32
char = 1;code = 49
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char = m;code = 109
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char = c;code = 99
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char = l;code = 108
char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = e;code = 101
char = a;code = 97
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char = u;code = 117
char = r;code = 114
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char = t;code = 116
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char = e;code = 101
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char = a;code = 97
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char = o;code = 111
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char = u;code = 117
char = t;code = 116
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char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = v;code = 118
char = e;code = 101
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char = c;code = 99
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char = u;code = 117
char = n;code = 110
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char = s;code = 115
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char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = l;code = 108
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = t;code = 116
char = o;code = 111
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char = b;code = 98
char = a;code = 97
char = c;code = 99
char = k;code = 107
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char = r;code = 114
char = o;code = 111
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char = d;code = 100
char = ;code = 32
char = (;code = 40
char = L;code = 76
char = /;code = 47
char = B;code = 66
char = );code = 41
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = D;code = 68
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = 7;code = 55
char = :;code = 58
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = t;code = 116
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char = s;code = 115
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char = r;code = 114
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = T;code = 84
char = x;code = 120
char = W;code = 87
char = B;code = 66
char = S;code = 83
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = e;code = 101
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char = f;code = 102
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char = r;code = 114
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char = d;code = 100
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char = u;code = 117
char = s;code = 115
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char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = m;code = 109
char = a;code = 97
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char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = o;code = 111
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char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = t;code = 116
char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = u;code = 117
char = a;code = 97
char = t;code = 116
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = e;code = 101
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char = s;code = 115
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = m;code = 109
char = o;code = 111
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char = a;code = 97
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char = s;code = 115
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char = r;code = 114
char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = s;code = 115
char = t;code = 116
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char = o;code = 111
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char = b;code = 98
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char = T;code = 84
char = x;code = 120
char = W;code = 87
char = B;code = 66
char = S;code = 83
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char = a;code = 97
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char = a;code = 97
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char = 7;code = 55
char = 6;code = 54
char = ;code = 32
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char = 4;code = 52
char = 1;code = 49
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char = 3;code = 51
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char = );code = 41
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = 5;code = 53
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char = b;code = 98
char = o;code = 111
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char = h;code = 104
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char = T;code = 84
char = x;code = 120
char = W;code = 87
char = B;code = 66
char = S;code = 83
char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = r;code = 114
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char = b;code = 98
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char = e;code = 101
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char = a;code = 97
char = l;code = 108
char = u;code = 117
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char = i;code = 105
char = o;code = 111
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char = .;code = 46
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char = D;code = 68
char = u;code = 117
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char = f;code = 102
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char = l;code = 108
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char = u;code = 117
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = U;code = 85
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char = 8;code = 56
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char = a;code = 97
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char = .;code = 46
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char = I;code = 73
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char = c;code = 99
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char = a;code = 97
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char = v;code = 118
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char = a;code = 97
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char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = ;code = 32
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char = a;code = 97
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char = g;code = 103
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char = ;code = 32
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char = ;code = 32
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char = m;code = 109
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char = e;code = 101
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char = l;code = 108
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char = c;code = 99
char = o;code = 111
char = -;code = 45
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char = e;code = 101
char = g;code = 103
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
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char = s;code = 115
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char = u;code = 117
char = r;code = 114
char = r;code = 114
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = I;code = 73
char = -;code = 45
char = 1;code = 49
char = 3;code = 51
char = 1;code = 49
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = F;code = 70
char = u;code = 117
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = d;code = 100
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = h;code = 104
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = s;code = 115
char = u;code = 117
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = -;code = 45
char = s;code = 115
char = u;code = 117
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char = g;code = 103
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char = x;code = 120
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char = B;code = 66
char = S;code = 83
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = <;code = 60
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result sql = In the present study we investigated the role of radio-guided surgery with Iodine-131 (I-131) in a group of 31 patients with differentiated thyroid cancer (DTC) and loco-regional recurrent disease. The principal inclusion criterion for I-131 radio-guided surgery in our protocol was the presence of an I-131 positive loco-regional disease relapse after previous total thyroidectomy and at least 2 ineffective conventional I-131 treatments. The protocol we used consisted of the following steps. Day 0: all patients were hospitalized and received a therapeutic 3.7 GBq (100 mCi) dose of I-131 after thyroid hormone therapy withdrawal in condition of overt hypothyroidism (serum TSH levels>30 microUI/ml). Day 3: a whole body scan following the therapeutic I-131 dose (TxWBS) administration was acquired. Day 5: neck surgery was performed through a wide bilateral neck exploration using a 15-mm collimated gamma probe, measuring the absolute intra-operative counts and calculating the lesion to background (L/B) ratio. Day 7: post-surgery TxWBS was performed using the remaining radioactivity to evaluate the completeness of tumoral lesions extirpation. The final histologic examination showed the presence of 184 metastatic foci; among them, 98 (53.2%) were evident by both TxWBS and gamma probe evaluation, 76 (41.3%) were demonstrated only by gamma probe, and 10 (5.4%) were negative by both TxWBS and gamma probe evaluation. During follow-up (8 months to 4.9 years, mean 2.8 years), DxWBS, serum Tg levels off l-T4, and US showed absence of loco-regional disease in 25 patients (80.6%) while 6 patients had persistent disease. In conclusion, this protocol allowed us to identify neoplastic foci with high sensitivity and specificity, enabling us to remove loco-regional I-131 disease recurrences resistant to previous conventional I-131 therapies. Furthermore, the gamma probe allowed detection of some additional tumoral foci in sclerotic areas or located behind vascular structures that were not visualized at the pre-surgery TxWBS evaluation.

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