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char = ;code = 32
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char = s;code = 115
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
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char = b;code = 98
char = i;code = 105
char = l;code = 108
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char = i;code = 105
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char = ;code = 32
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char = c;code = 99
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char = e;code = 101
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char = o;code = 111
char = ;code = 32
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char = d;code = 100
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = p;code = 112
char = o;code = 111
char = l;code = 108
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char = m;code = 109
char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = 5;code = 53
char = ';code = 39
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = p;code = 112
char = l;code = 108
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = .;code = 46
result sql = Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
Prostate cancer susceptibility is mediated by interactions between exposure to ultraviolet radiation and polymorphisms in the 5' haplotype block of the vitamin D receptor gene.
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char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = ;code = 32
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char = R;code = 82
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char = ;code = 32
char = p;code = 112
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char = i;code = 105
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char = ;code = 32
char = (;code = 40
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = n;code = 110
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char = ;code = 32
char = m;code = 109
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char = n;code = 110
char = n;code = 110
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char = r;code = 114
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char = ;code = 32
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char = n;code = 110
char = ;code = 32
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char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
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char = P;code = 80
char = s;code = 115
char = ;code = 32
char = i;code = 105
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char = ;code = 32
char = w;code = 119
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char = e;code = 101
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char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = r;code = 114
char = i;code = 105
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char = ;code = 32
char = V;code = 86
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
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char = l;code = 108
char = o;code = 111
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char = i;code = 105
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char = p;code = 112
char = l;code = 108
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = ;code = 32
char = C;code = 67
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = G;code = 71
char = (;code = 40
char = 3;code = 51
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char = 3;code = 51
char = 6;code = 54
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char = A;code = 65
char = (;code = 40
char = 3;code = 51
char = 9;code = 57
char = 4;code = 52
char = 4;code = 52
char = );code = 41
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char = C;code = 67
char = (;code = 40
char = 2;code = 50
char = 0;code = 48
char = 9;code = 57
char = 6;code = 54
char = 5;code = 53
char = );code = 41
char = -;code = 45
char = C;code = 67
char = (;code = 40
char = 3;code = 51
char = 0;code = 48
char = 0;code = 48
char = 5;code = 53
char = 6;code = 54
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = (;code = 40
char = G;code = 71
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = C;code = 67
char = );code = 41
char = -;code = 45
char = A;code = 65
char = -;code = 45
char = C;code = 67
char = -;code = 45
char = C;code = 67
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = A;code = 65
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char = (;code = 40
char = C;code = 67
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = T;code = 84
char = );code = 41
char = -;code = 45
char = C;code = 67
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = g;code = 103
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char = f;code = 102
char = i;code = 105
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char = s;code = 115
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char = t;code = 116
char = h;code = 104
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char = i;code = 105
char = n;code = 110
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = s;code = 115
char = k;code = 107
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char = (;code = 40
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char = d;code = 100
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char = i;code = 105
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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char = d;code = 100
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char = r;code = 114
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = i;code = 105
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char = n;code = 110
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char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = n;code = 110
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight.

Publication: Cancer Lett. 2007 Mar 18 ;247(2)::328-35.
Publication Date: 2007 Mar 18
Study Author(s): Rukin, Nicholas J;Luscombe, Christopher;Moon, Sam;Bodiwala, Dhaval;Liu, Samson;Saxby, Mark F;Fryer, Anthony A;Alldersea, Julie;Hoban, Paul R;Strange, Richard C;
Institution: Human Disease and Genomics Research Group, Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Staffordshire ST4 7PX, United Kingdom.
Shortcut link to this study:
Vitamin D receptor (VDR) polymorphisms are prostate cancer risk candidates. We determined if SNPs in haplotype block sub-regions C2 (SNPs C2-1, G/C(3436), C2-2, A/G(3944)) or C1 (C1-1, C/T(20965), C1-2, C/T(30056)) are associated with risk in an ultraviolet radiation (UVR)-dependent manner. In men with very low exposure, SNPs in both sub-regions were associated with risk. Various haplotypes in haplotype block C including G(3436)-A(3944)-C(20965)-C(30056), (G or C)-A-C-C and G-A-(C or T)-C were significantly associated with increased risk (odds ratios between 1.95 and 2.37). These findings suggest various block C SNPs are associated with prostate cancer risk via a mechanism involving exposure to sunlight.
PMID: 16815628

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