|
|
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result sql = Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.
Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.char = S;code = 83
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result sql = Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.
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char = e;code = 101
char = s;code = 115
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char = C;code = 67
char = O;code = 79
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char = s;code = 115
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char = h;code = 104
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char = t;code = 116
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char = l;code = 108
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char = c;code = 99
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result sql = Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma.
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result sql = Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.
Publication: Mol. Cell. Biochem. 2008 Jun ;313(1-2)::53-61. :doi: 10.1007/s11010-008-9741-5.
Publication Date: 2008 Jun
Study Author(s): Ramakrishnan, Gopalakrishnan;Elinos-Báez, Carmen Martha;Jagan, Sundaram;Augustine, Titto Alby;Kamaraj, Sattu;Anandakumar, Pandi;Devaki, Thiruvengadam;
Institution: Department of Biochemistry, University of Madras, Guindy campus, Chennai 600025, Tamilnadu, India.
Shortcut link to this study:
Publication Date: 2008 Jun
Study Author(s): Ramakrishnan, Gopalakrishnan;Elinos-Báez, Carmen Martha;Jagan, Sundaram;Augustine, Titto Alby;Kamaraj, Sattu;Anandakumar, Pandi;Devaki, Thiruvengadam;
Institution: Department of Biochemistry, University of Madras, Guindy campus, Chennai 600025, Tamilnadu, India.
Shortcut link to this study:
Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.
PMID: 18373278
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