|
|
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result sql = Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells.
Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells.char = <;code = 60
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result sql = OBJECTIVE : Recent clinical trials show that women who receive combined estrogen and progestin hormone therapy (HT) have a higher risk of breast cancer than women who receive estrogen alone or placebo. We have shown that progestins stimulate expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, in human breast cancer cells that express the progesterone receptors and mutant p53 protein. Because increased levels of VEGF promote tumor progression, compounds that prevent progestin-induced expression of VEGF could be clinically useful. The objective of this study was to examine whether the polyphenol compound curcumin has the capacity to block progestin-induced secretion of VEGF from T47-D human breast cancer cells.
DESIGN : The estrogen and progesterone receptor containing T47-D human breast cancer cells was exposed to 10 nM progesterone or synthetic progestins and varying concentrations of curcumin to determine whether curcumin blocks progestin-dependent production of VEGF from tumor cells.
RESULTS : Curcumin (0.001-10 microM for 18 h) reduced medroxyprogesterone acetate (MPA)-induced secretion of VEGF from T47-D cells in a dose-dependent manner. Secretion of VEGF from cells treated with progesterone or progestins other than MPA was unaffected by curcumin.
CONCLUSIONS : MPA is the most widely used progestin in HT. Curcumin may therefore provide a clinically useful tool for the suppression of MPA-induced elaboration of VEGF by tumor cells. We propose therefore that clinical trials to assess the beneficial effects of curcumin in postmenopausal women are warranted.
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char = r;code = 114
char = o;code = 111
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char = T;code = 84
char = 4;code = 52
char = 7;code = 55
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char = c;code = 99
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char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells.
char = b;code = 98
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char = O;code = 79
char = B;code = 66
char = J;code = 74
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char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = e;code = 101
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char = o;code = 111
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char = c;code = 99
char = e;code = 101
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char = h;code = 104
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char = m;code = 109
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char = h;code = 104
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char = a;code = 97
char = p;code = 112
char = y;code = 121
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char = (;code = 40
char = H;code = 72
char = T;code = 84
char = );code = 41
char = ;code = 32
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
char = ;code = 32
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char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = t;code = 116
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char = a;code = 97
char = n;code = 110
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char = w;code = 119
char = o;code = 111
char = m;code = 109
char = e;code = 101
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char = w;code = 119
char = h;code = 104
char = o;code = 111
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char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = e;code = 101
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char = a;code = 97
char = l;code = 108
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char = n;code = 110
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char = o;code = 111
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char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = b;code = 98
char = o;code = 111
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
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char = h;code = 104
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = n;code = 110
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char = s;code = 115
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char = e;code = 101
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char = s;code = 115
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = g;code = 103
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char = o;code = 111
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char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = V;code = 86
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char = G;code = 71
char = F;code = 70
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char = ,;code = 44
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char = a;code = 97
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char = p;code = 112
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char = t;code = 116
char = ;code = 32
char = a;code = 97
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char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = h;code = 104
char = u;code = 117
char = m;code = 109
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char = n;code = 110
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char = b;code = 98
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char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = ;code = 32
char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = s;code = 115
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char = p;code = 112
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char = g;code = 103
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char = c;code = 99
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char = t;code = 116
char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = p;code = 112
char = 5;code = 53
char = 3;code = 51
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = n;code = 110
char = .;code = 46
char = ;code = 32
char = B;code = 66
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char = c;code = 99
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char = e;code = 101
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
char = l;code = 108
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = V;code = 86
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char = G;code = 71
char = F;code = 70
char = ;code = 32
char = p;code = 112
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char = m;code = 109
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char = e;code = 101
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char = t;code = 116
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char = g;code = 103
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char = o;code = 111
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char = F;code = 70
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char = f;code = 102
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result sql = OBJECTIVE : Recent clinical trials show that women who receive combined estrogen and progestin hormone therapy (HT) have a higher risk of breast cancer than women who receive estrogen alone or placebo. We have shown that progestins stimulate expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, in human breast cancer cells that express the progesterone receptors and mutant p53 protein. Because increased levels of VEGF promote tumor progression, compounds that prevent progestin-induced expression of VEGF could be clinically useful. The objective of this study was to examine whether the polyphenol compound curcumin has the capacity to block progestin-induced secretion of VEGF from T47-D human breast cancer cells.
DESIGN : The estrogen and progesterone receptor containing T47-D human breast cancer cells was exposed to 10 nM progesterone or synthetic progestins and varying concentrations of curcumin to determine whether curcumin blocks progestin-dependent production of VEGF from tumor cells.
RESULTS : Curcumin (0.001-10 microM for 18 h) reduced medroxyprogesterone acetate (MPA)-induced secretion of VEGF from T47-D cells in a dose-dependent manner. Secretion of VEGF from cells treated with progesterone or progestins other than MPA was unaffected by curcumin.
CONCLUSIONS : MPA is the most widely used progestin in HT. Curcumin may therefore provide a clinically useful tool for the suppression of MPA-induced elaboration of VEGF by tumor cells. We propose therefore that clinical trials to assess the beneficial effects of curcumin in postmenopausal women are warranted.
Publication: Menopause 2008 May-Jun ;15(3)::570-4. :doi: 10.1097/gme.0b013e31814fae5d.
Publication Date: 2008 May-Jun
Study Author(s): Carroll, Candace E;Ellersieck, Mark R;Hyder, Salman M;
Institution: Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA.
Shortcut link to this study:
Publication Date: 2008 May-Jun
Study Author(s): Carroll, Candace E;Ellersieck, Mark R;Hyder, Salman M;
Institution: Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA.
Shortcut link to this study:
OBJECTIVE : Recent clinical trials show that women who receive combined estrogen and progestin hormone therapy (HT) have a higher risk of breast cancer than women who receive estrogen alone or placebo. We have shown that progestins stimulate expression of vascular endothelial growth factor (VEGF), a potent angiogenic factor, in human breast cancer cells that express the progesterone receptors and mutant p53 protein. Because increased levels of VEGF promote tumor progression, compounds that prevent progestin-induced expression of VEGF could be clinically useful. The objective of this study was to examine whether the polyphenol compound curcumin has the capacity to block progestin-induced secretion of VEGF from T47-D human breast cancer cells.
DESIGN : The estrogen and progesterone receptor containing T47-D human breast cancer cells was exposed to 10 nM progesterone or synthetic progestins and varying concentrations of curcumin to determine whether curcumin blocks progestin-dependent production of VEGF from tumor cells.
RESULTS : Curcumin (0.001-10 microM for 18 h) reduced medroxyprogesterone acetate (MPA)-induced secretion of VEGF from T47-D cells in a dose-dependent manner. Secretion of VEGF from cells treated with progesterone or progestins other than MPA was unaffected by curcumin.
CONCLUSIONS : MPA is the most widely used progestin in HT. Curcumin may therefore provide a clinically useful tool for the suppression of MPA-induced elaboration of VEGF by tumor cells. We propose therefore that clinical trials to assess the beneficial effects of curcumin in postmenopausal women are warranted.
DESIGN : The estrogen and progesterone receptor containing T47-D human breast cancer cells was exposed to 10 nM progesterone or synthetic progestins and varying concentrations of curcumin to determine whether curcumin blocks progestin-dependent production of VEGF from tumor cells.
RESULTS : Curcumin (0.001-10 microM for 18 h) reduced medroxyprogesterone acetate (MPA)-induced secretion of VEGF from T47-D cells in a dose-dependent manner. Secretion of VEGF from cells treated with progesterone or progestins other than MPA was unaffected by curcumin.
CONCLUSIONS : MPA is the most widely used progestin in HT. Curcumin may therefore provide a clinically useful tool for the suppression of MPA-induced elaboration of VEGF by tumor cells. We propose therefore that clinical trials to assess the beneficial effects of curcumin in postmenopausal women are warranted.
PMID: 18467956
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The order of these related concepts is determined by a statistical analysis of the scientific literature. Highest-frequency concepts appear first.
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